Entry Name Homologous recombination - Canis lupus familiaris (dog)
Description Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class Genetic Information Processing; Replication and repairBRITE hierarchy
Pathway map Other DBs Organism Canis lupus familiaris (dog) [GN:
cfa ]
Gene 100855690 RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
403568 RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482 ]
474180 BRCA2; breast cancer type 2 susceptibility protein [KO:K08775 ]
474674 RAD50; DNA repair protein RAD50 isoform X2 [KO:K10866 ] [EC:3.6.-.-]
475368 RAD54L; DNA repair and recombination protein RAD54-like isoform X3 [KO:K10875 ] [EC:5.6.2.-]
475524 SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111 ]
475711 BABAM2; BRISC and BRCA1-A complex member 2 isoform X2 [KO:K12173 ]
476021 MUS81; crossover junction endonuclease MUS81 isoform X4 [KO:K08991 ] [EC:3.1.22.-]
476676 BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776 ]
476806 POLD3; DNA polymerase delta subunit 3 isoform X3 [KO:K03504 ]
477070 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2 [KO:K10728 ]
477729 RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873 ]
478459 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774 ]
480175 RBBP8; DNA endonuclease RBBP8 [KO:K20773 ] [EC:3.1.-.-]
480573 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870 ]
481449 RPA3; replication protein A 14 kDa subunit [KO:K10740 ]
482686 POLD2; DNA polymerase delta subunit 2 isoform X3 [KO:K02328 ]
487053 RAD54B; DNA repair and recombination protein RAD54B isoform X3 [KO:K10877 ] [EC:5.6.2.-]
490746 RAD51B; DNA repair protein RAD51 homolog 2 isoform X2 [KO:K10869 ]
491079 EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882 ] [EC:3.1.22.-]
491143 RAD51D; DNA repair protein RAD51 homolog 4 isoform X2 [KO:K10871 ]
494006 MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865 ]
608719 SEM1; 26S proteasome complex subunit SEM1 [KO:K10881 ]
610190 BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683 ]
611298 UIMC1; BRCA1-A complex subunit RAP80 isoform X2 [KO:K20775 ]
612642 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X4 [KO:K11864 ] [EC:3.4.19.-]
Reference Authors Maloisel L, Fabre F, Gangloff S.
Title DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal Reference Authors Haruta-Takahashi N, Iwasaki H.
Title [Recombination mediators]
Journal Seikagaku 79:449-53 (2007)
Reference Authors Ouyang KJ, Woo LL, Ellis NA.
Title Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal Reference Authors Kawabata M, Kawabata T, Nishibori M.
Title Role of recA/RAD51 family proteins in mammals.
Journal Reference Authors Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title Mitotic recombination in Saccharomyces cerevisiae.
Journal Reference Authors Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title Rad54: the Swiss Army knife of homologous recombination?
Journal Reference Authors Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title Recombination proteins and rescue of arrested replication forks.
Journal KO pathway
