KEGG   PATHWAY: cfa03440
Entry
cfa03440                    Pathway                                
Name
Homologous recombination - Canis lupus familiaris (dog)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cfa03440  Homologous recombination
cfa03440

Other DBs
GO: 0000724
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
475524  SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
474674  RAD50; DNA repair protein RAD50 isoform X2 [KO:K10866] [EC:3.6.-.-]
494006  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
611315  NBN; nibrin isoform X2 [KO:K10867]
479450  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
403437  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
610190  BARD1; BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
102156002  LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1-like isoform X3 [KO:K10683]
480175  RBBP8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
111094686  DNA endonuclease RBBP8-like [KO:K20773] [EC:3.1.-.-]
491122  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
477070  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X2 [KO:K10728]
478459  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
611298  UIMC1; BRCA1-A complex subunit RAP80 isoform X2 [KO:K20775]
476676  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
475711  BABAM2; BRISC and BRCA1-A complex member 2 isoform X2 [KO:K12173]
612642  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X4 [KO:K11864] [EC:3.4.19.-]
610150  LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
608527  PALB2; partner and localizer of BRCA2 [KO:K10897]
474180  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
608719  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100684357  SYCP3; synaptonemal complex protein 3 isoform X1 [KO:K19528]
102152531  translation initiation factor IF-2-like isoform X11 [KO:K19528]
100855690  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
100856421  RPA2; replication protein A 32 kDa subunit [KO:K10739]
481449  RPA3; replication protein A 14 kDa subunit [KO:K10740]
403568  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
477729  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
490746  RAD51B; DNA repair protein RAD51 homolog 2 isoform X2 [KO:K10869]
480573  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
491143  RAD51D; DNA repair protein RAD51 homolog 4 isoform X2 [KO:K10871]
475548  XRCC2; DNA repair protein XRCC2 [KO:K10879]
100687200  XRCC3; DNA repair protein XRCC3 [KO:K10880]
475368  RAD54L; DNA repair and recombination protein RAD54-like isoform X3 [KO:K10875] [EC:5.6.2.-]
487053  RAD54B; DNA repair and recombination protein RAD54B isoform X3 [KO:K10877] [EC:5.6.2.-]
610047  POLD1; DNA polymerase delta catalytic subunit isoform X1 [KO:K02327] [EC:2.7.7.7]
482686  POLD2; DNA polymerase delta subunit 2 isoform X3 [KO:K02328]
476806  POLD3; DNA polymerase delta subunit 3 isoform X3 [KO:K03504]
611847  DNA polymerase delta subunit 4 isoform X4 [KO:K03505]
100685609  BLM; Bloom syndrome protein isoform X2 [KO:K10901] [EC:5.6.2.4]
477576  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
489537  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
476021  MUS81; crossover junction endonuclease MUS81 isoform X4 [KO:K08991] [EC:3.1.22.-]
491079  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG GENES (44)   
All databases (45)   

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