KEGG   PATHWAY: cga03440Help
Entry
cga03440                    Pathway                                

Name
Homologous recombination - Cellulomonas gilvus
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
cga03440  Homologous recombination
cga03440

Ortholog table
Module
cga_M00260  DNA polymerase III complex, bacteria [PATH:cga03440]
Other DBs
BSID: 372990
GO: 0000724
Organism
Cellulomonas gilvus [GN:cga]
Gene
Celgi_3184  single-strand binding protein [KO:K03111]
Celgi_2215  single-strand binding protein [KO:K03111]
Celgi_0004  DNA replication and repair protein RecF [KO:K03629]
Celgi_1251  DNA repair protein RecO [KO:K03584]
Celgi_2857  recombination protein RecR [KO:K06187]
Celgi_2046  recA protein [KO:K03553]
Celgi_1619  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Celgi_2185  DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
Celgi_1581  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Celgi_1582  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Celgi_1580  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Celgi_1160  DEAD/DEAH box helicase domain protein [KO:K03655] [EC:3.6.4.12]
Celgi_2265  Exodeoxyribonuclease V [KO:K03582] [EC:3.1.11.5]
Celgi_2264  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Celgi_2266  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Celgi_1984  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Celgi_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Celgi_2858  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Celgi_1215  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Celgi_0314  AAA ATPase [KO:K02341] [EC:2.7.7.7]
Celgi_0511  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Celgi_0886  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Celgi_1428  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Celgi_1773  primosomal protein N' (replication factor Y) - superfamily II helicase-like protein [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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