KEGG   PATHWAY: chc03440Help
Entry
chc03440                    Pathway                                

Name
Homologous recombination - Chlamydia psittaci C19/98
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
chc03440  Homologous recombination
chc03440

Ortholog table
Other DBs
BSID: 599099
GO: 0000724
Organism
Chlamydia psittaci C19/98 [GN:chc]
Gene
CPS0C_0206  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
CPS0C_0452  ssb; single-strand binding family protein [KO:K03111]
CPS0C_0492  recF; recombination protein F [KO:K03629]
CPS0C_0175  recO; DNA repair protein RecO [KO:K03584]
CPS0C_0533  recR; recombination protein RecR [KO:K06187]
CPS0C_1073  recA; recombinase A [KO:K03553]
CPS0C_0146  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CPS0C_0136  ruvA; holliday junction DNA helicase [KO:K03550] [EC:3.6.4.12]
CPS0C_0448  ruvB; holliday junction DNA helicase [KO:K03551] [EC:3.6.4.12]
CPS0C_0135  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
CPS0C_0009  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
CPS0C_0010  putative exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
CPS0C_0707  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
CPS0C_1083  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
CPS0C_0086  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
CPS0C_0493  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
CPS0C_0560  DNA polymerase III subunit [KO:K02343] [EC:2.7.7.7]
CPS0C_0370  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
CPS0C_0455  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
CPS0C_0099  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
CPS0C_0424  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
CPS0C_0910  putative primosome assembly protein [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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