KEGG   PATHWAY: chx05170
Entry
chx05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Capra hircus (goat)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
chx05170  Human immunodeficiency virus 1 infection
chx05170

Organism
Capra hircus (goat) [GN:chx]
Gene
102170124  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
102187079  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
102184871  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
102174738  S-phase kinase-associated protein 1 [KO:K03094]
108633185  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102189276  CUL1; cullin-1 [KO:K03347]
102188771  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102187112  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
102169916  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102178672  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100860765  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102185804  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108635583  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102186145  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102184810  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102178097  PXN; paxillin isoform X1 [KO:K05760]
102175206  CRKL; crk-like protein [KO:K04438]
102174330  CRK; adapter molecule crk isoform X1 [KO:K04438]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100860902  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100861297  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102169319  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
102182675  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102174096  RELA; transcription factor p65 [KO:K04735]
102171520  FOS; proto-oncogene c-Fos [KO:K04379]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102189950  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102177328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102181878  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102180337  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102170858  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102185007  CALM1; calmodulin [KO:K02183]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102175311  calmodulin [KO:K02183]
106502751  calmodulin-like protein 3 [KO:K02183]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102169697  CALM3; calmodulin [KO:K02183]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102188180  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102180958  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102184725  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102172114  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102175984  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102187070  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102169841  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102191178  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102174574  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102189312  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
102184123  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102170665  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102190485  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102183232  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102189040  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106502450  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102186081  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102182581  uncharacterized LOC105372280 homolog [KO:K04347]
102175543  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102190190  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
102185427  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
102190164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102178149  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102178569  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102180827  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102176919  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102183402  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102182530  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102181217  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
100860973  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102177680  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102171364  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102180632  CFL2; cofilin-2 [KO:K05765]
102170587  CFL1; cofilin-1 [KO:K05765]
100861232  TNF; tumor necrosis factor [KO:K03156]
102191447  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
100860747  TLR2; toll-like receptor 2 precursor [KO:K10159]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102174883  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102171575  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102177432  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102172830  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102185161  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102187405  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102172719  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102187049  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
102171058  STING1; stimulator of interferon genes protein [KO:K12654]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
102171811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102184324  DNA dC->dU-editing enzyme APOBEC-3C isoform X1 [KO:K18750] [EC:3.5.4.-]
106502146  DNA dC->dU-editing enzyme APOBEC-3G isoform X1 [KO:K18750] [EC:3.5.4.-]
102178551  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
102170165  LOW QUALITY PROTEIN: tripartite motif-containing protein 5 [KO:K10648] [EC:2.3.2.27]
102173185  tripartite motif-containing protein 5 isoform X1 [KO:K10648] [EC:2.3.2.27]
102169889  tripartite motif-containing protein 5 [KO:K10648] [EC:2.3.2.27]
108637671  tripartite motif-containing protein 5-like [KO:K10648] [EC:2.3.2.27]
102179935  tripartite motif-containing protein 5 isoform X1 [KO:K10648] [EC:2.3.2.27]
102173377  BST2; bone marrow stromal antigen 2 [KO:K06731]
108636404  bone marrow stromal antigen 2-like [KO:K06731]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102178407  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
102180248  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102188243  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102173967  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102169516  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102178753  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102180451  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102170562  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
106501717  cytochrome c 2 [KO:K08738]
102173997  cytochrome c [KO:K08738]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102190711  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
102191440  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
102191154  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
102173900  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
102181173  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102180638  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102191658  TAPBP; tapasin [KO:K08058]
100860882  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
102185733  CALR; calreticulin [KO:K08057]
102172138  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102180584  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102188814  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
102181202  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
108633459  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
108633460  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102183314  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102176782  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102170045  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102168905  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102169753  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102185917  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102181347  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
108633505  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
102175817  patr class I histocompatibility antigen, alpha chain G-like [KO:K06751]
102171703  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102185295  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
102170051  AP1G2; AP-1 complex subunit gamma-like 2 isoform X3 [KO:K12391]
102179509  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
102178441  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
102189301  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
102177702  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
102170040  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
102184293  AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
102168267  B2M; beta-2-microglobulin [KO:K08055]
102168547  beta-2-microglobulin [KO:K08055]
102175351  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
102182517  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
102190245  CUL5; cullin-5 isoform X2 [KO:K10612]
102180802  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
102191656  DCAF1; protein VPRBP isoform X1 [KO:K11789] [EC:2.7.11.1]
102173071  DDB1; DNA damage-binding protein 1 [KO:K10610]
102190766  CUL4B; cullin-4B isoform X1 [KO:K10609]
102175217  CUL4A; cullin-4A [KO:K10609]
102190803  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102178489  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102184881  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
102187214  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
102179791  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
102176379  LOW QUALITY PROTEIN: wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
102176664  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
102187875  G2/mitotic-specific cyclin-B1 [KO:K05868]
102188170  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
102179856  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102186469  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
100861361  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
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J Med Chem 55:977-94 (2012)
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J Biol Chem 286:12554-64 (2011)
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Front Microbiol 5:177 (2014)
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Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
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J Virol 86:757-72 (2012)
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Curr Opin HIV AIDS 11:173-81 (2016)
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Nat Immunol 16:554-62 (2015)
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Trends Immunol 29:61-7 (2008)
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Cell Death Dis 1:e99 (2010)
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Nat Rev Immunol 3:392-404 (2003)
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Viruses 3:586-612 (2011)
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Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
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Viruses 8:67 (2016)
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Methods Mol Biol 1170:165-227 (2014)
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Curr HIV Res 3:43-51 (2005)
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HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
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PLoS Pathog 2:e127 (2006)
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PMID:23430691
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Takaori-Kondo A, Shindo K
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HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
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Front Microbiol 4:34 (2013)
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PMID:19038776
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APOBEC proteins and intrinsic resistance to HIV-1 infection.
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Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
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PMID:21835787
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Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
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Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
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J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
chx03050  Proteasome
chx04010  MAPK signaling pathway
chx04020  Calcium signaling pathway
chx04064  NF-kappa B signaling pathway
chx04110  Cell cycle
chx04141  Protein processing in endoplasmic reticulum
chx04142  Lysosome
chx04150  mTOR signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04612  Antigen processing and presentation
chx04620  Toll-like receptor signaling pathway
chx04623  Cytosolic DNA-sensing pathway
chx04668  TNF signaling pathway
chx04810  Regulation of actin cytoskeleton
KO pathway
ko05170   

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Genome (1)   
   KEGG GENOME (1)   
Gene (230)   
   KEGG GENES (230)   
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