KEGG   PATHWAY: cle03440Help
Entry
cle03440                    Pathway                                

Name
Homologous recombination - Cellulosilyticum lentocellum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
cle03440  Homologous recombination
cle03440

Ortholog table
Module
cle_M00260  DNA polymerase III complex, bacteria [PATH:cle03440]
Other DBs
BSID: 213505
GO: 0000724
Organism
Cellulosilyticum lentocellum [GN:cle]
Gene
Clole_1346  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Clole_1072  single-strand binding protein [KO:K03111]
Clole_0945  single-strand binding protein [KO:K03111]
Clole_0004  DNA replication and repair protein RecF [KO:K03629]
Clole_2062  DNA repair protein RecO [KO:K03584]
Clole_1032  Recombination protein recR [KO:K06187]
Clole_2467  recA protein [KO:K03553]
Clole_2063  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Clole_2381  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Clole_2380  Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:3.6.4.12]
Clole_1786  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
Clole_3024  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Clole_3601  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Clole_2585  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Clole_2523  DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
Clole_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Clole_1030  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Clole_2121  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Clole_0013  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Clole_0717  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Clole_1772  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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