KEGG   PATHWAY: clo03440Help
Entry
clo03440                    Pathway                                

Name
Homologous recombination - Mageeibacillus indolicus
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
clo03440  Homologous recombination
clo03440

Ortholog table
Module
clo_M00260  DNA polymerase III complex, bacteria [PATH:clo03440]
Other DBs
BSID: 145081
GO: 0000724
Organism
Mageeibacillus indolicus [GN:clo]
Gene
HMPREF0868_1338  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
HMPREF0868_1385  single-strand binding family protein [KO:K03111]
HMPREF0868_0091  recF; DNA replication and repair protein RecF [KO:K03629]
HMPREF0868_0956  recO; DNA repair protein RecO [KO:K03584]
HMPREF0868_1021  recR; recombination protein RecR [KO:K06187]
HMPREF0868_0632  recA; RecA protein [KO:K03553]
HMPREF0868_0853  polA; DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
HMPREF0868_0917  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
HMPREF0868_0916  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
HMPREF0868_0918  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
HMPREF0868_0349  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
HMPREF0868_0115  divergent AAA domain protein [KO:K03655] [EC:3.6.4.12]
HMPREF0868_0621  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
HMPREF0868_0936  polC; DNA polymerase III, alpha subunit, Gram-positive type [KO:K03763] [EC:2.7.7.7]
HMPREF0868_0092  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
HMPREF0868_1019  dnaX; DNA polymerase III, subunit gamma and tau [KO:K02343] [EC:2.7.7.7]
HMPREF0868_0895  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
HMPREF0868_1013  DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
HMPREF0868_0935  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

DBGET integrated database retrieval system