KEGG   PATHWAY: clu03440
Entry
clu03440                    Pathway                                
Name
Homologous recombination - Clavispora lusitaniae ATCC 42720
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
clu03440  Homologous recombination
clu03440

Other DBs
GO: 0000724
Organism
Clavispora lusitaniae ATCC 42720 [GN:clu]
Gene
CLUG_02228  hypothetical protein [KO:K10866] [EC:3.6.-.-]
CLUG_05723  hypothetical protein [KO:K10865]
CLUG_03791  hypothetical protein [KO:K04728] [EC:2.7.11.1]
CLUG_02994  hypothetical protein [KO:K10881]
CLUG_00514  hypothetical protein [KO:K10958]
CLUG_00788  hypothetical protein [KO:K07466]
CLUG_05823  hypothetical protein [KO:K10739]
CLUG_00558  hypothetical protein [KO:K10740]
CLUG_03761  hypothetical protein [KO:K04482]
CLUG_00513  hypothetical protein [KO:K04482]
CLUG_01569  hypothetical protein [KO:K10873]
CLUG_02568  hypothetical protein [KO:K10959]
CLUG_03244  hypothetical protein [KO:K10875] [EC:5.6.2.-]
CLUG_04866  hypothetical protein [KO:K10877] [EC:5.6.2.-]
CLUG_03181  hypothetical protein [KO:K02327] [EC:2.7.7.7]
CLUG_03182  similar to DNA polymerase III [KO:K02327] [EC:2.7.7.7]
CLUG_01803  hypothetical protein [KO:K02328]
CLUG_05545  hypothetical protein [KO:K03504]
CLUG_00201  hypothetical protein [KO:K10901] [EC:5.6.2.4]
CLUG_03009  hypothetical protein [KO:K03165] [EC:5.6.2.1]
CLUG_03697  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG GENES (21)   
All databases (22)   

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