KEGG   PATHWAY: cne04145
Entry
cne04145                    Pathway                                
Name
Phagosome - Cryptococcus neoformans var. neoformans JEC21
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cne04145  Phagosome
cne04145

Other DBs
GO: 0045335
Organism
Cryptococcus neoformans var. neoformans JEC21 [GN:cne]
Gene
CNF01710  conserved hypothetical protein [KO:K08492]
CND03150  hypothetical protein [KO:K08517]
CNJ02000  GTPase, putative [KO:K07889]
CNM01190  GTPase, putative [KO:K07889]
CNB03120  phosphatidylinositol 3-kinase, putative [KO:K00914] [EC:2.7.1.137]
CNE03710  vacuolar protein sorting-associated protein vps27, putative [KO:K12182]
CNE02210  endodeoxyribonuclease, putative [KO:K02145] [EC:7.1.2.2]
CNI01180  vacuolar ATP synthase, putative [KO:K02147]
CNC06660  conserved hypothetical protein [KO:K02148]
CNC00590  vacuolar ATP synthase subunit d, putative [KO:K02149]
CNA05420  vacuolar ATP synthase subunit e, putative [KO:K02150]
CNF02860  conserved hypothetical protein [KO:K02151]
CNF01900  hypothetical protein [KO:K02152]
CNL04630  hypothetical protein [KO:K02153]
CND02320  vacuolar (H+)-ATPase subunit, putative [KO:K02154]
CNA04290  vacuolar ATP synthase subunit d, putative [KO:K02146]
CNA06920  conserved hypothetical protein [KO:K02144]
CNK03340  hydrogen ion transporter, putative [KO:K02155]
CNA02690  conserved hypothetical protein [KO:K02155]
CNJ02380  hydrogen-transporting ATPase, putative [KO:K03661]
CNK00660  RAB small monomeric GTPase, putative [KO:K07897]
CNF00790  motor, putative [KO:K10413]
CNI01410  dynein intermediate chain, putative [KO:K10415]
CNA05070  conserved hypothetical protein [KO:K10416]
CNB02810  alpha tubulin, putative [KO:K07374]
CNL06670  Tubulin beta chain, putative [KO:K07375]
CNC03260  beta1-tubulin, putative [KO:K07375]
CND03330  1-phosphatidylinositol-3-phosphate 5-kinase, putative [KO:K00921] [EC:2.7.1.150]
CNM01630  hypothetical protein [KO:K00921] [EC:2.7.1.150]
CNH02735  hypothetical protein [KO:K10089]
CNI00040  protein transporter, putative [KO:K10956]
CNN00800  hypothetical protein [KO:K09481]
CNA00580  conserved hypothetical protein [KO:K07342]
CNE00610  ER-associated protein catabolism-related protein, putative [KO:K08054]
CNC04960  small GTPase, putative [KO:K04392]
CNM00070  Rho GTPase, putative [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cne04144  Endocytosis
KO pathway
ko04145   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG GENES (36)   
All databases (37)   

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