KEGG   PATHWAY: ctg03440
Entry
ctg03440                    Pathway                                
Name
Homologous recombination - Chlamydia trachomatis E/11023
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ctg03440  Homologous recombination
ctg03440

Other DBs
GO: 0000724
Organism
Chlamydia trachomatis E/11023 [GN:ctg]
Gene
E11023_02335  single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
E11023_00235  single-stranded DNA-binding protein [KO:K03111]
E11023_00395  recF; recombination protein F [KO:K03629]
E11023_02465  recO; DNA repair protein RecO [KO:K03584]
E11023_01235  recR; recombination protein RecR [KO:K06187]
E11023_03430  recA; recombinase A [KO:K03553]
E11023_02645  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
E11023_00215  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
E11023_02650  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
E11023_03370  exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
E11023_03375  exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
E11023_03440  exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
E11023_00175  exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
E11023_02865  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
E11023_00400  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
E11023_01740  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
E11023_00965  DNA polymerase III subunit delta' [KO:K02343] [EC:2.7.7.7]
E11023_00250  hypothetical protein [KO:K02340] [EC:2.7.7.7]
E11023_01350  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
E11023_02820  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
E11023_04115  primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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