KEGG   PATHWAY: cvr01210
Entry
cvr01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Chlorella variabilis
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
cvr01210  2-Oxocarboxylic acid metabolism
cvr01210

Module
cvr_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cvr01210]
cvr_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:cvr01210]
cvr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cvr01210]
Organism
Chlorella variabilis [GN:cvr]
Related
pathway
cvr00020  Citrate cycle (TCA cycle)
cvr00220  Arginine biosynthesis
cvr00250  Alanine, aspartate and glutamate metabolism
cvr00260  Glycine, serine and threonine metabolism
cvr00270  Cysteine and methionine metabolism
cvr00290  Valine, leucine and isoleucine biosynthesis
cvr00300  Lysine biosynthesis
cvr00310  Lysine degradation
cvr00620  Pyruvate metabolism
cvr00640  Propanoate metabolism
cvr00966  Glucosinolate biosynthesis
KO pathway
ko01210   

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