KEGG   PATHWAY: cwo00020
Entry
cwo00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Conexibacter woesei
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cwo00020  Citrate cycle (TCA cycle)
cwo00020

Module
cwo_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:cwo00020]
cwo_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cwo00020]
cwo_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:cwo00020]
cwo_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cwo00020]
Other DBs
GO: 0006099
Organism
Conexibacter woesei [GN:cwo]
Gene
Cwoe_5814  Citrate (Si)-synthase [KO:K01647] [EC:2.3.3.1]
Cwoe_1088  citrate synthase I [KO:K01647] [EC:2.3.3.1]
Cwoe_0997  aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
Cwoe_0911  isocitrate dehydrogenase, NADP-dependent [KO:K00031] [EC:1.1.1.42]
Cwoe_4396  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Cwoe_0768  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Cwoe_4712  pyruvate flavodoxin/ferredoxin oxidoreductase domain protein [KO:K00174] [EC:1.2.7.3 1.2.7.11]
Cwoe_4711  thiamine pyrophosphate protein domain protein TPP-binding protein [KO:K00175] [EC:1.2.7.3 1.2.7.11]
Cwoe_5544  succinyl-CoA synthetase, alpha subunit [KO:K01902] [EC:6.2.1.5]
Cwoe_4215  CoA-binding domain protein [KO:K01902] [EC:6.2.1.5]
Cwoe_5543  succinyl-CoA synthetase, beta subunit [KO:K01903] [EC:6.2.1.5]
Cwoe_5261  succinate dehydrogenase or fumarate reductase, flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
Cwoe_5284  succinate dehydrogenase or fumarate reductase, flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
Cwoe_5260  succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00240] [EC:1.3.5.1]
Cwoe_5285  succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00240] [EC:1.3.5.1]
Cwoe_5262  succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family [KO:K00241]
Cwoe_5286  CoB--CoM heterodisulfide reductase [KO:K00241]
Cwoe_5854  fumarate lyase [KO:K01679] [EC:4.2.1.2]
Cwoe_5280  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
Cwoe_2457  pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
Cwoe_4211  Phosphoenolpyruvate carboxykinase (GTP) [KO:K01596] [EC:4.1.1.32]
Cwoe_0670  Transketolase domain protein [KO:K00163] [EC:1.2.4.1]
Cwoe_5216  Pyruvate dehydrogenase (acetyl-transferring) [KO:K00161] [EC:1.2.4.1]
Cwoe_2191  3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) [KO:K00161] [EC:1.2.4.1]
Cwoe_4399  Pyruvate dehydrogenase (acetyl-transferring) [KO:K00161] [EC:1.2.4.1]
Cwoe_5215  Transketolase central region [KO:K00162] [EC:1.2.4.1]
Cwoe_2192  Transketolase central region [KO:K00162] [EC:1.2.4.1]
Cwoe_4398  Transketolase central region [KO:K00162] [EC:1.2.4.1]
Cwoe_2774  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_2751  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_0765  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_5079  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_2193  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_4397  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_0671  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_1945  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Cwoe_4316  Dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
Cwoe_4078  Dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
Cwoe_4401  catalytic domain of components of various dehydrogenase complexes [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cwo00010  Glycolysis / Gluconeogenesis
cwo00053  Ascorbate and aldarate metabolism
cwo00061  Fatty acid biosynthesis
cwo00071  Fatty acid degradation
cwo00190  Oxidative phosphorylation
cwo00220  Arginine biosynthesis
cwo00250  Alanine, aspartate and glutamate metabolism
cwo00280  Valine, leucine and isoleucine degradation
cwo00350  Tyrosine metabolism
cwo00470  D-Amino acid metabolism
cwo00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   

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