KEGG   PATHWAY: dac00290
Entry
dac00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Delftia acidovorans
Class
Metabolism; Amino acid metabolism
Pathway map
dac00290  Valine, leucine and isoleucine biosynthesis
dac00290

Module
dac_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:dac00290]
dac_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:dac00290]
dac_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:dac00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Delftia acidovorans [GN:dac]
Gene
Daci_5685  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Daci_0116  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Daci_3585  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K17989] [EC:4.3.1.17 4.3.1.19]
Daci_5235  3-isopropylmalate dehydratase, large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
Daci_5237  3-isopropylmalate dehydratase, small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
Daci_5238  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
Daci_2284  thiamine pyrophosphate protein central region [KO:K01652] [EC:2.2.1.6]
Daci_1020  thiamine pyrophosphate protein domain protein TPP-binding [KO:K01652] [EC:2.2.1.6]
Daci_4867  acetolactate synthase, large subunit, biosynthetic type [KO:K01652] [EC:2.2.1.6]
Daci_0959  thiamine pyrophosphate protein central region [KO:K01652] [EC:2.2.1.6]
Daci_4866  acetolactate synthase, small subunit [KO:K01653] [EC:2.2.1.6]
Daci_4865  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
Daci_2450  Dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
Daci_3009  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
Daci_2756  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
Daci_0316  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
Daci_5220  aminotransferase class I and II [KO:K14260] [EC:2.6.1.66 2.6.1.2]
Daci_4862  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Daci_5293  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Daci_4863  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
dac00260  Glycine, serine and threonine metabolism
dac00280  Valine, leucine and isoleucine degradation
dac00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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