KEGG   PATHWAY: dgr03013
Entry
dgr03013                    Pathway                                
Name
Nucleocytoplasmic transport - Drosophila grimshawi
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
dgr03013  Nucleocytoplasmic transport
dgr03013

Other DBs
GO: 0050658
Organism
Drosophila grimshawi [GN:dgr]
Gene
6564477  aladin isoform X1 [KO:K14320]
6566709  nucleoporin AMO1 [KO:K14321]
6561035  nucleoporin Gle1 [KO:K18723]
6556637  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
6568817  protein Rae1 [KO:K14298]
6567595  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
6561008  nuclear pore complex protein Nup214 [KO:K14317]
6567520  nuclear pore complex protein Nup88 [KO:K14318]
6567589  E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
6561595  ran GTPase-activating protein [KO:K14319]
6562404  SUMO-conjugating enzyme UBC9-B [KO:K10577]
6566950  small ubiquitin-related modifier 3 [KO:K12160]
6562181  nuclear pore complex protein Nup160 homolog [KO:K14303]
6561178  nuclear pore complex protein Nup75 [KO:K14304]
6563679  protein SEC13 homolog [KO:K14004]
6562361  nuclear pore complex protein Nup107 [KO:K14301]
6567499  nuclear pore complex protein Nup133 [KO:K14300]
6559599  nucleoporin seh1 [KO:K14299]
6563369  nucleoporin Nup43 [KO:K14305]
6568270  nucleoporin Nup37 [KO:K14302]
6564538  protein ELYS homolog [KO:K25129]
6561313  nuclear pore glycoprotein p62 [KO:K14306]
6567636  nuclear pore complex protein Nup58 [KO:K14307]
6560013  probable nucleoporin Nup54 [KO:K14308]
6566320  nuclear pore complex protein Nup205 [KO:K14310]
6560776  nucleoporin Nup188 [KO:K14311]
6567083  nuclear pore complex protein Nup154 [KO:K14312]
6564414  nuclear pore complex protein Nup93-1 [KO:K14309]
6569196  nuclear pore complex protein Nup93-1 [KO:K14309]
6564759  nucleoporin Nup35 [KO:K14313]
6568121  nucleoporin Ndc1 [KO:K14315]
6560000  nuclear pore membrane glycoprotein 210 [KO:K14314]
6563604  mucin-5AC [KO:K14316]
6562697  Krueppel homolog 2 [KO:K20724]
6560273  nucleoprotein TPR isoform X1 [KO:K09291]
6559435  nuclear pore complex protein Nup50 [KO:K14295]
116805643  nuclear pore complex protein Nup153 [KO:K14296]
6559418  importin subunit alpha [KO:K15043]
6562213  importin subunit alpha [KO:K15043]
6562044  importin subunit alpha isoform X1 [KO:K15043]
6563353  importin subunit alpha-3 [KO:K23583]
6558439  importin subunit alpha-7 isoform X2 [KO:K15042]
6562215  importin subunit beta [KO:K14293]
6557521  transportin-1 [KO:K18752]
6562279  transportin-3 [KO:K15436]
6558452  importin-4 [KO:K20221]
6563184  importin-5 [KO:K20222]
6558786  importin-7 [KO:K20223]
6567415  importin-9 [KO:K20224]
6569157  importin-11 [KO:K25201]
6568054  importin-13 [KO:K25202]
6557780  ras-interacting protein RIP3 [KO:K13151]
116806508  snurportin-1 [KO:K13151]
6566492  exportin-1 [KO:K14290]
6566588  exportin-2 [KO:K18423]
6564539  exportin-5 [KO:K14289]
6566185  exportin-6-A [KO:K25204]
6564739  ran-binding protein 16 [KO:K18460]
6558317  GTP-binding nuclear protein Ran [KO:K07936]
6566364  GTP-binding nuclear protein Ran [KO:K07936]
6563064  elongation factor 1-alpha 2 [KO:K03231]
6559322  elongation factor 1-alpha 1 [KO:K03231]
6559788  phosphorylated adapter RNA export protein [KO:K14291]
6562089  nuclear cap-binding protein subunit 1 [KO:K12882]
6566283  nuclear cap-binding protein subunit 1 [KO:K12882]
6568059  nuclear cap-binding protein subunit 2 [KO:K12883]
6569281  60S ribosomal export protein NMD3 [KO:K07562]
6559911  RNA-binding protein 8A [KO:K12876]
6559892  protein mago nashi [KO:K12877]
6568071  mediator of RNA polymerase II transcription subunit 12 [KO:K14323]
6568470  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
6562348  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
6563438  histone deacetylase complex subunit SAP18 [KO:K14324]
6564894  suppressor protein SRP40 [KO:K14325]
6563710  RNA-binding protein with serine-rich domain 1-A [KO:K14325]
6563918  THO complex subunit 4 [KO:K12881]
6564880  regulator of nonsense transcripts 1 homolog isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
6565792  regulator of nonsense transcripts 2 [KO:K14327]
6559919  regulator of nonsense transcripts 3B [KO:K14328]
6563742  nuclear RNA export factor 1 [KO:K14284]
6564525  nuclear RNA export factor 1 [KO:K14284]
6567990  nuclear RNA export factor 1 [KO:K14284]
116805827  uncharacterized protein LOC116805827 [KO:K14284]
6565869  NTF2-related export protein isoform X1 [KO:K14285]
6566824  NTF2-related export protein [KO:K14285]
6566051  NTF2-related export protein [KO:K14285]
116805860  NTF2-related export protein-like [KO:K14285]
6562731  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
6557596  serine/arginine repetitive matrix protein 1 [KO:K13171]
116805081  partner of Y14 and mago [KO:K14294]
6568129  THO complex subunit 1 [KO:K12878]
6566579  THO complex subunit 2 [KO:K12879]
6559342  LOW QUALITY PROTEIN: THO complex subunit 5 [KO:K13174]
6558416  THO complex subunit 6 [KO:K13175]
6558673  THO complex protein 7 [KO:K13176]
6567943  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
dgr03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (96)   
   KEGG GENES (96)   
All databases (97)   

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