KEGG   PATHWAY: dme00190
Entry
dme00190                    Pathway                                

Name
Oxidative phosphorylation - Drosophila melanogaster (fruit fly)
Class
Metabolism; Energy metabolism
Pathway map
dme00190  Oxidative phosphorylation
dme00190

Module
dme_M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:dme00190]
dme_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:dme00190]
dme_M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:dme00190]
dme_M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:dme00190]
dme_M00148  Succinate dehydrogenase (ubiquinone) [PATH:dme00190]
dme_M00151  Cytochrome bc1 complex respiratory unit [PATH:dme00190]
dme_M00152  Cytochrome bc1 complex [PATH:dme00190]
dme_M00154  Cytochrome c oxidase [PATH:dme00190]
dme_M00158  F-type ATPase, eukaryotes [PATH:dme00190]
dme_M00160  V-type ATPase, eukaryotes [PATH:dme00190]
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG34092  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Dmel_CG34063  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
Dmel_CG34076  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
Dmel_CG34085  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
Dmel_CG34086  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
Dmel_CG34083  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
Dmel_CG34089  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
Dmel_CG2286  ND-75; NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform A [KO:K03934] [EC:7.1.1.2]
Dmel_CG1970  ND-49; NADH dehydrogenase (ubiquinone) 49 kDa subunit, isoform B [KO:K03935] [EC:7.1.1.2]
Dmel_CG11913  ND-49L; NADH dehydrogenase (ubiquinone) 49 kDa subunit-like [KO:K03935] [EC:7.1.1.2]
Dmel_CG12079  ND-30; NADH dehydrogenase (ubiquinone) 30 kDa subunit [KO:K03936] [EC:7.1.1.2]
Dmel_CG12203  ND-18; NADH dehydrogenase (ubiquinone) 18 kDa subunit [KO:K03937]
Dmel_CG11455  ND-15; NADH dehydrogenase (ubiquinone) 15 kDa subunit, isoform C [KO:K03938]
Dmel_CG8680  ND-13A; NADH dehydrogenase (ubiquinone) 13 kDa A subunit, isoform B [KO:K03939]
Dmel_CG9172  ND-20; NADH dehydrogenase (ubiquinone) 20 kDa subunit, isoform C [KO:K03940] [EC:7.1.1.2]
Dmel_CG2014  ND-20L; NADH dehydrogenase (ubiquinone) 20 kDa subunit-like, isoform B [KO:K03940] [EC:7.1.1.2]
Dmel_CG3944  ND-23; NADH dehydrogenase (ubiquinone) 23 kDa subunit [KO:K03941] [EC:7.1.1.2]
Dmel_CG9140  ND-51; NADH dehydrogenase (ubiquinone) 51 kDa subunit, isoform B [KO:K03942] [EC:7.1.1.2]
Dmel_CG11423  ND-51L1; NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 1 [KO:K03942] [EC:7.1.1.2]
Dmel_CG8102  ND-51L2; NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2, isoform B [KO:K03942] [EC:7.1.1.2]
Dmel_CG5703  ND-24; NADH dehydrogenase (ubiquinone) 24 kDa subunit, isoform B [KO:K03943] [EC:7.1.1.2]
Dmel_CG6485  ND-24L; NADH dehydrogenase (ubiquinone) 24 kDa subunit-like [KO:K03943] [EC:7.1.1.2]
Dmel_CG34439  ND-MWFE; NADH dehydrogenase (ubiquinone) MWFE subunit, isoform A [KO:K03945]
Dmel_CG15434  ND-B8; NADH dehydrogenase (ubiquinone) B8 subunit [KO:K03946]
Dmel_CG32230  ND-MLRQ; NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform C [KO:K03948]
Dmel_CG6463  ND-13B; NADH dehydrogenase (ubiquinone) 13 kDa B subunit [KO:K03949]
Dmel_CG7712  ND-B14; NADH dehydrogenase (ubiquinone) B14 subunit, isoform B [KO:K03950]
Dmel_CG3621  ND-B14.5A; NADH dehydrogenase (ubiquinone) B14.5 A subunit, isoform B [KO:K03951]
Dmel_CG6914  ND-B14.5AL; NADH dehydrogenase (ubiquinone) B14.5 A subunit-like [KO:K03951]
Dmel_CG3683  ND-19; NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform D [KO:K03952]
Dmel_CG6020  ND-39; NADH dehydrogenase (ubiquinone) 39 kDa subunit, isoform B [KO:K03953]
Dmel_CG6343  ND-42; NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform C [KO:K03954]
Dmel_CG9160  ND-ACP; NADH dehydrogenase (ubiquinone) acyl carrier protein, isoform A [KO:K03955]
Dmel_CG9350  ND-B14.7; NADH dehydrogenase (ubiquinone) B14.7 subunit [KO:K03956]
Dmel_CG3214  ND-B17.2; NADH dehydrogenase (ubiquinone) B17.2 subunit, isoform B [KO:K11352]
Dmel_CG3446  ND-B16.6; NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform B [KO:K11353]
Dmel_CG18624  ND-MNLL; NADH dehydrogenase (ubiquinone) MNLL subunit, isoform C [KO:K03957]
Dmel_CG40002  ND-AGGG; NADH dehydrogenase (ubiquinone) AGGG subunit, isoform A [KO:K03958]
Dmel_CG40472  CG40472; uncharacterized protein [KO:K03958]
Dmel_CG10320  ND-B12; NADH dehydrogenase (ubiquinone) B12 subunit, isoform B [KO:K03959]
Dmel_CG12859  ND-B15; NADH dehydrogenase (ubiquinone) B15 subunit [KO:K03960]
Dmel_CG9762  ND-SGDH; NADH dehydrogenase (ubiquinone) SGDH subunit, isoform B [KO:K03961]
Dmel_CG13240  ND-B17; NADH dehydrogenase (ubiquinone) B17 subunit, isoform A [KO:K03962]
Dmel_CG5548  ND-B18; NADH dehydrogenase (ubiquinone) B18 subunit, isoform B [KO:K03963]
Dmel_CG3192  ND-ASHI; NADH dehydrogenase (ubiquinone) ASHI subunit, isoform B [KO:K03964]
Dmel_CG9306  ND-B22; NADH dehydrogenase (ubiquinone) B22 subunit, isoform B [KO:K03965]
Dmel_CG8844  ND-PDSW; NADH dehydrogenase (ubiquinone) PDSW subunit, isoform A [KO:K03966]
Dmel_CG6008  NP15.6; NP15.6 [KO:K11351]
Dmel_CG12400  ND-B14.5B; NADH dehydrogenase (ubiquinone) B14.5 B subunit, isoform B [KO:K03968]
Dmel_CG17246  SdhA; succinate dehydrogenase, subunit A (flavoprotein), isoform A [KO:K00234] [EC:1.3.5.1]
Dmel_CG5718  SdhAL; succinate dehydrogenase, subunit A (flavoprotein)-like [KO:K00234] [EC:1.3.5.1]
Dmel_CG3283  SdhB; succinate dehydrogenase, subunit B (iron-sulfur) [KO:K00235] [EC:1.3.5.1]
Dmel_CG7349  SdhBL; succinate dehydrogenase, subunit B (iron-sulfur)-like, isoform C [KO:K00235] [EC:1.3.5.1]
Dmel_CG6629  CG6629; uncharacterized protein [KO:K00236]
Dmel_CG6666  SdhC; succinate dehydrogenase, subunit C, isoform B [KO:K00236]
Dmel_CG10219  SdhD; succinate dehydrogenase, subunit D [KO:K00237]
Dmel_CG7361  RFeSP; rieske iron-sulfur protein, isoform D [KO:K00411] [EC:7.1.1.8]
Dmel_CG34090  CYTB; cytochrome b [KO:K00412]
Dmel_CG14508  Cyt-c1L; cytochrome c1-like [KO:K00413]
Dmel_CG4769  Cyt-c1; cytochrome c1, isoform B [KO:K00413]
Dmel_CG4169  UQCR-C2; Ubiquinol-cytochrome c reductase core protein 2, isoform B [KO:K00415]
Dmel_CG30354  UQCR-11L; Ubiquinol-cytochrome c reductase 11 kDa subunit-like, isoform B [KO:K00416]
Dmel_CG41623  UQCR-11; Ubiquinol-cytochrome c reductase 11 kDa subunit, isoform D [KO:K00416]
Dmel_CG17856  UQCR-14L; Ubiquinol-cytochrome c reductase 14 kDa subunit-like [KO:K00417]
Dmel_CG3560  UQCR-14; Ubiquinol-cytochrome c reductase 14 kDa subunit [KO:K00417]
Dmel_CG7580  UQCR-Q; Ubiquinol-cytochrome c reductase ubiquinone-binding protein, isoform B [KO:K00418]
Dmel_CG8764  ox; oxen [KO:K00419]
Dmel_CG14482  UQCR-6.4; Ubiquinol-cytochrome c reductase 6.4 kDa subunit, isoform B [KO:K00420]
Dmel_CG43206  CG43206; uncharacterized protein [KO:K00420]
Dmel_CG5037  CG5037; uncharacterized protein [KO:K02257] [EC:2.5.1.141]
Dmel_CG34074  COX3; cytochrome c oxidase subunit III [KO:K02262]
Dmel_CG34067  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
Dmel_CG34069  COX2; cytochrome c oxidase subunit II [KO:K02261]
Dmel_CG10664  COX4; cytochrome c oxidase subunit 4, isoform C [KO:K02263]
Dmel_CG10396  COX4L; cytochrome c oxidase subunit 4-like, isoform B [KO:K02263]
Dmel_CG14724  COX5A; cytochrome c oxidase subunit 5A, isoform C [KO:K02264]
Dmel_CG11015  COX5B; cytochrome c oxidase subunit 5B, isoform B [KO:K02265]
Dmel_CG11043  COX5BL; cytochrome c oxidase subunit 5B-like [KO:K02265]
Dmel_CG17280  levy; levy, isoform B [KO:K02266]
Dmel_CG14077  CG14077; uncharacterized protein, isoform C [KO:K02266]
Dmel_CG30093  COX6AL; cytochrome c oxidase subunit 6A-like [KO:K02266]
Dmel_CG14235  COX6B; cytochrome c oxidase subunit 6B, isoform D [KO:K02267]
Dmel_CG14028  cype; cyclope, isoform B [KO:K02268]
Dmel_CG31644  CG31644; uncharacterized protein, isoform B [KO:K02268]
Dmel_CG9603  COX7A; cytochrome c oxidase subunit 7A, isoform A [KO:K02270]
Dmel_CG18193  COX7AL; cytochrome c oxidase subunit 7A-like [KO:K02270]
Dmel_CG2249  COX7C; cytochrome c oxidase subunit 7C, isoform C [KO:K02272]
Dmel_CG44296  CG44296; uncharacterized protein [KO:K02272]
Dmel_CG7181  COX8; cytochrome c oxidase subunit 8, isoform B [KO:K02273]
Dmel_CG31648  CG31648; uncharacterized protein [KO:K02258]
Dmel_CG3803  CG3803; uncharacterized protein [KO:K02259] [EC:1.17.99.9]
Dmel_CG9065  CG9065; uncharacterized protein [KO:K02260]
Dmel_CG3612  blw; bellwether [KO:K02132]
Dmel_CG5389  ATPsynbetaL; ATP synthase, beta subunit-like [KO:K02133] [EC:7.1.2.2]
Dmel_CG11154  ATPsynbeta; ATP synthase, beta subunit, isoform D [KO:K02133] [EC:7.1.2.2]
Dmel_CG7610  ATPsyngamma; ATP synthase, gamma subunit, isoform A [KO:K02136]
Dmel_CG2968  ATPsyndelta; ATP synthase, delta subunit, isoform B [KO:K02134]
Dmel_CG9032  sun; stunted, isoform A [KO:K02135]
Dmel_CG31477  ATPsynepsilonL; ATP synthase, epsilon subunit-like, isoform B [KO:K02135]
Dmel_CG4307  ATPsynO; ATP synthase, oligomycin sensitivity conferring protein [KO:K02137]
Dmel_CG34073  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
Dmel_CG8189  ATPsynB; ATP synthase, subunit B [KO:K02127]
Dmel_CG1746  ATPsynC; ATP synthase, subunit C, isoform E [KO:K02128]
Dmel_CG6030  ATPsynD; ATP synthase, subunit D, isoform C [KO:K02138]
Dmel_CG3321  ATPsynE; ATP synthase, subunit E, isoform C [KO:K02129]
Dmel_CG4692  ATPsynF; ATP synthase, subunit F, isoform B [KO:K02130]
Dmel_CG7211  ATPsynGL; ATP synthase, subunit G-like [KO:K02140]
Dmel_CG6105  ATPsynG; ATP synthase, subunit G, isoform B [KO:K02140]
Dmel_CG4412  ATPsynCF6; ATP synthase, coupling factor 6, isoform B [KO:K02131]
Dmel_CG34072  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
Dmel_CG3762  Vha68-2; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [KO:K02145] [EC:7.1.2.2]
Dmel_CG5075  Vha68-3; vacuolar H[+] ATPase 68kD subunit 3 [KO:K02145] [EC:7.1.2.2]
Dmel_CG12403  Vha68-1; vacuolar H[+] ATPase 68kD subunit 1, isoform B [KO:K02145] [EC:7.1.2.2]
Dmel_CG17369  Vha55; vacuolar H[+]-ATPase 55kD subunit, isoform C [KO:K02147]
Dmel_CG8048  Vha44; vacuolar H[+] ATPase 44kD subunit, isoform F [KO:K02148]
Dmel_CG8310  Vha36-3; vacuolar H[+] ATPase 36kD subunit 3, isoform C [KO:K02149]
Dmel_CG8186  Vha36-1; vacuolar H[+] ATPase 36kD subunit 1 [KO:K02149]
Dmel_CG13167  Vha36-2; vacuolar H[+] ATPase 36kD subunit 2 [KO:K02149]
Dmel_CG1088  Vha26; vacuolar H[+]-ATPase 26kD subunit, isoform C [KO:K02150]
Dmel_CG8210  Vha14-1; vacuolar H[+] ATPase 14kD subunit 1 [KO:K02151]
Dmel_CG1076  Vha14-2; vacuolar H[+] ATPase 14kD subunit 2, isoform A [KO:K02151]
Dmel_CG15719  CG15719; uncharacterized protein, isoform D [KO:K02151]
Dmel_CG6213  Vha13; vacuolar H[+] ATPase 13kD subunit, isoform B [KO:K02152]
Dmel_CG17332  VhaSFD; vacuolar H[+]-ATPase SFD subunit, isoform E [KO:K02144]
Dmel_CG12602  Vha100-5; vacuolar H[+] ATPase 100kD subunit 5, isoform B [KO:K02154]
Dmel_CG30329  Vha100-3; vacuolar H[+] ATPase 100kD subunit 3 [KO:K02154]
Dmel_CG1709  Vha100-1; vacuolar H[+] ATPase 100kD subunit 1, isoform I [KO:K02154]
Dmel_CG7678  Vha100-4; vacuolar H[+] ATPase 100kD subunit 4 [KO:K02154]
Dmel_CG18617  Vha100-2; vacuolar H[+] ATPase 100kD subunit 2, isoform B [KO:K02154]
Dmel_CG3161  Vha16-1; vacuolar H[+] ATPase 16kD subunit 1, isoform A [KO:K02155]
Dmel_CG6737  Vha16-5; vacuolar H[+] ATPase 16kD subunit 5 [KO:K02155]
Dmel_CG9013  Vha16-4; vacuolar H[+] ATPase 16kD subunit 4 [KO:K02155]
Dmel_CG32090  Vha16-3; vacuolar H[+] ATPase 16kD subunit 3, isoform B [KO:K02155]
Dmel_CG32089  Vha16-2; vacuolar H[+] ATPase 16kD subunit 2 [KO:K02155]
Dmel_CG7007  VhaPPA1-1; vacuolar H[+] ATPase PPA1 subunit 1, isoform B [KO:K03661]
Dmel_CG7026  VhaPPA1-2; vacuolar H[+] ATPase PPA1 subunit 2 [KO:K03661]
Dmel_CG2934  VhaAC39-1; vacuolar H[+] ATPase AC39 subunit 1 [KO:K02146]
Dmel_CG4624  VhaAC39-2; vacuolar H[+] ATPase AC39 subunit 2 [KO:K02146]
Dmel_CG7625  VhaM9.7-b; vacuolar H[+] ATPase M9.7 subunit b, isoform B [KO:K02153]
Dmel_CG1268  VhaM9.7-a; vacuolar H[+] ATPase M9.7 subunit a, isoform B [KO:K02153]
Dmel_CG11589  VhaM9.7-c; vacuolar H[+] ATPase M9.7 subunit c [KO:K02153]
Dmel_CG14909  VhaM9.7-d; vacuolar H[+] ATPase M9.7 subunit d [KO:K02153]
Dmel_CG8029  VhaAC45; vacuolar H[+] ATPase AC45 accessory subunit, isoform B [KO:K03662]
Dmel_CG4634  Nurf-38; nucleosome remodeling factor - 38kD, isoform A [KO:K11726] [EC:3.6.1.1]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00061  FMN
C00080  H+
C00122  Fumarate
C00390  Ubiquinol
C00399  Ubiquinone
C00524  Cytochrome c
C00536  Triphosphate
Reference
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
KO pathway
ko00190   

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