KEGG   PATHWAY: dme00790
Entry
dme00790                    Pathway                                
Name
Folate biosynthesis - Drosophila melanogaster (fruit fly)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
dme00790  Folate biosynthesis
dme00790

Module
dme_M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:dme00790]
dme_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:dme00790]
Other DBs
GO: 0046656
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG10118  ple; pale, isoform C [KO:K00501] [EC:1.14.16.2]
Dmel_CG10238  Mocs2B; molybdenum cofactor synthesis 2B [KO:K03635] [EC:2.8.1.12]
Dmel_CG10592  Alp10; alkaline phosphatase 10 [KO:K01077] [EC:3.1.3.1]
Dmel_CG10638  CG10638; uncharacterized protein, isoform D [KO:K00011] [EC:1.1.1.21]
Dmel_CG10827  Alp5; alkaline phosphatase 5 [KO:K01077] [EC:3.1.3.1]
Dmel_CG10863  CG10863; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG12116  CG12116; uncharacterized protein [KO:K00072] [EC:1.1.1.153]
Dmel_CG12117  Sptr; sepiapterin reductase [KO:K00072] [EC:1.1.1.153]
Dmel_CG12766  CG12766; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG1462  Alp4; alkaline phosphatase 4, isoform A [KO:K01077] [EC:3.1.3.1]
Dmel_CG14887  Dhfr; dihydrofolate reductase, isoform B [KO:K00287] [EC:1.5.1.3]
Dmel_CG16771  Alp12; alkaline phosphatase 12, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG16784  pr; purple [KO:K01737] [EC:4.2.3.12 4.1.2.50]
Dmel_CG1692  mal; maroon-like, isoform B [KO:K15631] [EC:2.8.1.9]
Dmel_CG1809  Alp6; alkaline phosphatase 6 [KO:K01077] [EC:3.1.3.1]
Dmel_CG1963  Pcd; pterin-4a-carbinolamine dehydratase [KO:K01724] [EC:4.2.1.96]
Dmel_CG2543  Fpgs1; folylpolyglutamate synthase 1, isoform B [KO:K01930] [EC:6.3.2.17]
Dmel_CG2945  cin; cinnamon, isoform A [KO:K15376] [EC:2.10.1.1 2.7.7.75]
Dmel_CG31773  Fpgs2; folylpolyglutamate synthase 2 [KO:K01930] [EC:6.3.2.17]
Dmel_CG32155  l(3)72Dp; lethal (3) 72Dp [KO:K01307] [EC:3.4.19.9]
Dmel_CG3264  Alp8; alkaline phosphatase 8, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG3290  Alp2; alkaline phosphatase 2 [KO:K01077] [EC:3.1.3.1]
Dmel_CG3292  Alp7; alkaline phosphatase 7 [KO:K01077] [EC:3.1.3.1]
Dmel_CG33048  Mocs1; molybdenum cofactor synthesis 1, isoform C [KO:K20967] [EC:4.1.99.22 4.6.1.17]
Dmel_CG40064  ARY; Aldo-keto reductase on Y, isoform C [KO:K00011] [EC:1.1.1.21]
Dmel_CG4665  Dhpr; dihydropteridine reductase, isoform B [KO:K00357] [EC:1.5.1.34]
Dmel_CG5150  Alp9; alkaline phosphatase 9, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG5361  Alp13; alkaline phosphatase 13 [KO:K01077] [EC:3.1.3.1]
Dmel_CG5656  Alp1; alkaline phosphatase 1, isoform B [KO:K01077] [EC:3.1.3.1]
Dmel_CG6083  CG6083; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG6084  Akr1B; Aldo-keto reductase 1B, isoform C [KO:K00011] [EC:1.1.1.21]
Dmel_CG6781  se; sepia [KO:K00310] [EC:1.5.4.1]
Dmel_CG7399  Hn; henna, isoform C [KO:K00500] [EC:1.14.16.1]
Dmel_CG8105  Alp11; alkaline phosphatase 11 [KO:K01077] [EC:3.1.3.1]
Dmel_CG8147  phu; phurba tashi [KO:K01077] [EC:3.1.3.1]
Dmel_CG9122  Trhn; tryptophan hydroxylase neuronal [KO:K00502] [EC:1.14.16.4]
Dmel_CG9436  CG9436; uncharacterized protein [KO:K00011] [EC:1.1.1.21]
Dmel_CG9441  Pu; punch, isoform A [KO:K01495] [EC:3.5.4.16]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
dme00230  Purine metabolism
dme00400  Phenylalanine, tyrosine and tryptophan biosynthesis
dme00670  One carbon pool by folate
KO pathway
ko00790   

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