KEGG   PATHWAY: dme03008
Entry
dme03008                    Pathway                                

Name
Ribosome biogenesis in eukaryotes - Drosophila melanogaster (fruit fly)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
dme03008  Ribosome biogenesis in eukaryotes
dme03008

Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG13591  Ssl; suppressor of Stellate-like [KO:K03115]
Dmel_CG8914  CkIIbeta2; casein kinase II beta2 subunit [KO:K03115]
Dmel_CG15224  CkIIbeta; casein kinase II beta subunit, isoform E [KO:K03115]
Dmel_CG33242  Ste:CG33242 [KO:K03115]
Dmel_CG33239  Ste:CG33239 [KO:K03115]
Dmel_CG33241  Ste:CG33241 [KO:K03115]
Dmel_CG33236  Ste:CG33236 [KO:K03115]
Dmel_CG33237  Ste:CG33237 [KO:K03115]
Dmel_CG33240  Ste:CG33240 [KO:K03115]
Dmel_CG33244  Ste:CG33244 [KO:K03115]
Dmel_CG33245  Ste:CG33245 [KO:K03115]
Dmel_CG33247  Ste:CG33247 [KO:K03115]
Dmel_CG32616  Ste12DOR; stellate 12D orphon [KO:K03115]
Dmel_CG33243  Ste:CG33243 [KO:K03115]
Dmel_CG33238  Ste:CG33238 [KO:K03115]
Dmel_CG33246  Ste:CG33246 [KO:K03115]
Dmel_CG42398  SteXh:CG42398 [KO:K03115]
Dmel_CG40635  CG40635; uncharacterized protein [KO:K03115]
Dmel_CG17520  CkIIalpha; casein kinase IIalpha, isoform D [KO:K03097] [EC:2.7.11.1]
Dmel_CG12785  Mat89Ba; maternal transcript 89Ba [KO:K14544]
Dmel_CG9107  CG9107; uncharacterized protein, isoform B [KO:K14545]
Dmel_CG30349  CG30349; uncharacterized protein [KO:K14546]
Dmel_CG5018  l(3)72Dn; lethal (3) 72Dn, isoform B [KO:K14548]
Dmel_CG3071  CG3071; uncharacterized protein [KO:K14549]
Dmel_CG10805  l(2)k09022; lethal (2) k09022 [KO:K14550]
Dmel_CG12050  l(2)05287; lethal (2) 05287 [KO:K14552]
Dmel_CG7989  wcd; wicked [KO:K14553]
Dmel_CG9799  CG9799; uncharacterized protein [KO:K14554]
Dmel_CG1671  CG1671; uncharacterized protein [KO:K14555]
Dmel_CG8064  CG8064; uncharacterized protein [KO:K14556]
Dmel_CG7246  CG7246; uncharacterized protein [KO:K14557]
Dmel_CG12325  CG12325; uncharacterized protein, isoform B [KO:K14558]
Dmel_CG13097  CG13097; uncharacterized protein [KO:K14559]
Dmel_CG4866  CG4866; uncharacterized protein [KO:K14560]
Dmel_CG11920  CG11920; uncharacterized protein [KO:K14561]
Dmel_CG9888  Fib; fibrillarin [KO:K14563] [EC:2.1.1.-]
Dmel_CG10909  CG10909; uncharacterized protein [KO:K14563] [EC:2.1.1.-]
Dmel_CG13849  Nop56; Nop56 [KO:K14564]
Dmel_CG10206  nop5; nop5 [KO:K14565]
Dmel_CG3949  hoip; hoi-polloi, isoform B [KO:K12845]
Dmel_CG3333  Nop60B; nucleolar protein at 60B, isoform B [KO:K11131] [EC:5.4.99.-]
Dmel_CG5258  NHP2; NHP2, isoform B [KO:K11129]
Dmel_CG4038  CG4038; uncharacterized protein [KO:K11128]
Dmel_CG7637  CG7637; uncharacterized protein [KO:K11130]
Dmel_CG4539  Bka; bekka [KO:K14566]
Dmel_CG12301  CG12301; uncharacterized protein [KO:K14567]
Dmel_CG8730  drosha; drosha [KO:K03685] [EC:3.1.26.3]
Dmel_CG3527  CG3527; uncharacterized protein [KO:K14568] [EC:2.1.1.260]
Dmel_CG7728  CG7728; uncharacterized protein [KO:K14569]
Dmel_CG1994  l(1)G0020; lethal (1) G0020, isoform A [KO:K14521] [EC:2.3.1.-]
Dmel_CG11130  Rtc1; Rtc1 [KO:K11108]
Dmel_CG32763  Pop1; POP1 ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
Dmel_CG8038  Pop4; POP4 ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
Dmel_CG14057  Pop5; POP5 ribonuclease P/MRP subunit, isoform B [KO:K03537] [EC:3.1.26.5]
Dmel_CG9422  Rpp25; ribonuclease P/MRP subunit p25, isoform D [KO:K14525] [EC:3.1.26.5]
Dmel_CG33931  Rpp20; Rpp20, isoform A [KO:K14527] [EC:3.1.26.5]
Dmel_CG11606  Rpp30; RNaseP protein p30, isoform B [KO:K03539] [EC:3.1.26.5]
Dmel_CG12877  CG12877; uncharacterized protein [KO:K14570] [EC:3.1.-.-]
Dmel_CG8368  Rexo5; RNA exonuclease 5, isoform A [KO:K14570] [EC:3.1.-.-]
Dmel_CG42666  prage; prage, isoform E [KO:K14570] [EC:3.1.-.-]
Dmel_CG10214  CG10214; uncharacterized protein [KO:K13288] [EC:3.1.-.-]
Dmel_CG3291  pcm; pacman, isoform B [KO:K12618] [EC:3.1.13.-]
Dmel_CG10354  Rat1; Rat1 5'-3' exoribonuclease, isoform B [KO:K12619] [EC:3.1.13.-]
Dmel_CG8801  Non1; novel nucleolar protein 1, isoform B [KO:K06943]
Dmel_CG6501  Ns2; nucleostemin 2 [KO:K14537]
Dmel_CG3983  Ns1; nucleostemin 1 [KO:K14538]
Dmel_CG8571  smid; smallminded, isoform C [KO:K14571]
Dmel_CG13185  CG13185; uncharacterized protein [KO:K14572]
Dmel_CG4806  CG4806; uncharacterized protein [KO:K14573]
Dmel_CG2972  CG2972; uncharacterized protein, isoform B [KO:K11883]
Dmel_CG1404  Ran; Ran, isoform C [KO:K07936]
Dmel_CG7815  Ran-like [KO:K07936]
Dmel_CG13387  emb; embargoed, isoform B [KO:K14290]
Dmel_CG3460  Nmd3; Nonsense-mediated mRNA 3 [KO:K07562]
Dmel_CG1664  sbr; small bristles, isoform A [KO:K14284]
Dmel_CG32135  Nxf3; nuclear export factor 3, isoform E [KO:K14284]
Dmel_CG31501  nxf4; nuclear export factor 4 [KO:K14284]
Dmel_CG12752  Nxt1; NTF2-related export protein 1, isoform A [KO:K14285]
Dmel_CG17611  eIF6; eukaryotic translation initiation factor 6 [KO:K03264]
Dmel_CG8549  CG8549; uncharacterized protein, isoform B [KO:K14574]
Dmel_CG33158  CG33158; uncharacterized protein [KO:K14536] [EC:3.6.5.-]
Dmel_CG14788  Ns3; nucleostemin 3, isoform B [KO:K14539] [EC:3.6.1.-]
Dmel_CG5776  CG5776; uncharacterized protein, isoform B [KO:K14575]
Dmel_CG8816  Ak6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
Dmel_CG11660  RIOK1; RIO kinase 1, isoform A [KO:K07178] [EC:2.7.11.1]
Dmel_CG11859  RIOK2; RIO kinase 2 [KO:K07179] [EC:2.7.11.1]
Dmel_CR34096  srRNA; 12S ribosomal RNA [KO:K01979]
Dmel_CR45838  18SrRNA:CR45838; 18S ribosomal RNA [KO:K01979]
Dmel_CR41548  18SrRNA:CR41548; 18S ribosomal RNA [KO:K01979]
Dmel_CR45841  18SrRNA:CR45841; 18S ribosomal RNA [KO:K01979]
Dmel_CR45852  5.8SrRNA:CR45852; 5.8S ribosomal RNA [KO:K01986]
Dmel_CR45839  5.8SrRNA:CR45839; 5.8S ribosomal RNA [KO:K01986]
Dmel_CR45842  5.8SrRNA:CR45842; 5.8S ribosomal RNA [KO:K01986]
Dmel_CR40454  5.8SrRNA:CR40454; 5.8S ribosomal RNA [KO:K01986]
Dmel_CR34094  lrRNA; 16S ribosomal RNA [KO:K01982]
Dmel_CR45844  28SrRNA:CR45844; 28S ribosomal RNA [KO:K01982]
Dmel_CR33357  5SrRNA:CR33357; 5S ribosomal RNA [KO:K01981]
Dmel_CR33390  5SrRNA:CR33390; 5S ribosomal RNA [KO:K01981]
Dmel_CR33437  5SrRNA:CR33437; 5S ribosomal RNA [KO:K01981]
Dmel_CR33361  5SrRNA:CR33361; 5S ribosomal RNA [KO:K01981]
Dmel_CR33369  5SrRNA:CR33369; 5S ribosomal RNA [KO:K01981]
Dmel_CR33442  5SrRNA:CR33442; 5S ribosomal RNA [KO:K01981]
Dmel_CR33402  5SrRNA:CR33402; 5S ribosomal RNA [KO:K01981]
Dmel_CR33434  5SrRNA:CR33434; 5S ribosomal RNA [KO:K01981]
Dmel_CR33435  5SrRNA:CR33435; 5S ribosomal RNA [KO:K01981]
Dmel_CR33399  5SrRNA:CR33399; 5S ribosomal RNA [KO:K01981]
Dmel_CR33430  5SrRNA:CR33430; 5S ribosomal RNA [KO:K01981]
Dmel_CR33451  5SrRNA:CR33451; 5S ribosomal RNA [KO:K01981]
Dmel_CR33355  5SrRNA:CR33355; 5S ribosomal RNA [KO:K01981]
Dmel_CR33425  5SrRNA:CR33425; 5S ribosomal RNA [KO:K01981]
Dmel_CR33415  5SrRNA:CR33415; 5S ribosomal RNA [KO:K01981]
Dmel_CR33449  5SrRNA:CR33449; 5S ribosomal RNA [KO:K01981]
Dmel_CR33438  5SrRNA:CR33438; 5S ribosomal RNA [KO:K01981]
Dmel_CR33417  5SrRNA:CR33417; 5S ribosomal RNA [KO:K01981]
Dmel_CR33414  5SrRNA:CR33414; 5S ribosomal RNA [KO:K01981]
Dmel_CR33397  5SrRNA:CR33397; 5S ribosomal RNA [KO:K01981]
Dmel_CR33395  5SrRNA:CR33395; 5S ribosomal RNA [KO:K01981]
Dmel_CR33436  5SrRNA:CR33436; 5S ribosomal RNA [KO:K01981]
Dmel_CR33433  5SrRNA:CR33433; 5S ribosomal RNA [KO:K01981]
Dmel_CR33389  5SrRNA:CR33389; 5S ribosomal RNA [KO:K01981]
Dmel_CR33386  5SrRNA:CR33386; 5S ribosomal RNA [KO:K01981]
Dmel_CR33380  5SrRNA:CR33380; 5S ribosomal RNA [KO:K01981]
Dmel_CR33443  5SrRNA:CR33443; 5S ribosomal RNA [KO:K01981]
Dmel_CR33354  5SrRNA:CR33354; 5S ribosomal RNA [KO:K01981]
Dmel_CR33426  5SrRNA:CR33426; 5S ribosomal RNA [KO:K01981]
Dmel_CR33359  5SrRNA:CR33359; 5S ribosomal RNA [KO:K01981]
Dmel_CR33388  5SrRNA:CR33388; 5S ribosomal RNA [KO:K01981]
Dmel_CR33400  5SrRNA:CR33400; 5S ribosomal RNA [KO:K01981]
Dmel_CR33366  5SrRNA:CR33366; 5S ribosomal RNA [KO:K01981]
Dmel_CR33420  5SrRNA:CR33420; 5S ribosomal RNA [KO:K01981]
Dmel_CR33418  5SrRNA:CR33418; 5S ribosomal RNA [KO:K01981]
Dmel_CR33409  5SrRNA:CR33409; 5S ribosomal RNA [KO:K01981]
Dmel_CR33429  5SrRNA:CR33429; 5S ribosomal RNA [KO:K01981]
Dmel_CR33360  5SrRNA:CR33360; 5S ribosomal RNA [KO:K01981]
Dmel_CR33367  5SrRNA:CR33367; 5S ribosomal RNA [KO:K01981]
Dmel_CR33375  5SrRNA:CR33375; 5S ribosomal RNA [KO:K01981]
Dmel_CR33411  5SrRNA:CR33411; 5S ribosomal RNA [KO:K01981]
Dmel_CR33353  5SrRNA:CR33353; 5S ribosomal RNA [KO:K01981]
Dmel_CR33406  5SrRNA:CR33406; 5S ribosomal RNA [KO:K01981]
Dmel_CR33422  5SrRNA:CR33422; 5S ribosomal RNA [KO:K01981]
Dmel_CR33383  5SrRNA:CR33383; 5S ribosomal RNA [KO:K01981]
Dmel_CR33379  5SrRNA:CR33379; 5S ribosomal RNA [KO:K01981]
Dmel_CR33365  5SrRNA:CR33365; 5S ribosomal RNA [KO:K01981]
Dmel_CR33364  5SrRNA:CR33364; 5S ribosomal RNA [KO:K01981]
Dmel_CR33423  5SrRNA:CR33423; 5S ribosomal RNA [KO:K01981]
Dmel_CR33424  5SrRNA:CR33424; 5S ribosomal RNA [KO:K01981]
Dmel_CR33396  5SrRNA:CR33396; 5S ribosomal RNA [KO:K01981]
Dmel_CR33381  5SrRNA:CR33381; 5S ribosomal RNA [KO:K01981]
Dmel_CR33408  5SrRNA:CR33408; 5S ribosomal RNA [KO:K01981]
Dmel_CR33427  5SrRNA:CR33427; 5S ribosomal RNA [KO:K01981]
Dmel_CR33432  5SrRNA:CR33432; 5S ribosomal RNA [KO:K01981]
Dmel_CR33440  5SrRNA:CR33440; 5S ribosomal RNA [KO:K01981]
Dmel_CR33392  5SrRNA:CR33392; 5S ribosomal RNA [KO:K01981]
Dmel_CR33445  5SrRNA:CR33445; 5S ribosomal RNA [KO:K01981]
Dmel_CR33372  5SrRNA:CR33372; 5S ribosomal RNA [KO:K01981]
Dmel_CR33403  5SrRNA:CR33403; 5S ribosomal RNA [KO:K01981]
Dmel_CR33401  5SrRNA:CR33401; 5S ribosomal RNA [KO:K01981]
Dmel_CR33439  5SrRNA:CR33439; 5S ribosomal RNA [KO:K01981]
Dmel_CR33378  5SrRNA:CR33378; 5S ribosomal RNA [KO:K01981]
Dmel_CR33384  5SrRNA:CR33384; 5S ribosomal RNA [KO:K01981]
Dmel_CR33431  5SrRNA:CR33431; 5S ribosomal RNA [KO:K01981]
Dmel_CR33419  5SrRNA:CR33419; 5S ribosomal RNA [KO:K01981]
Dmel_CR33398  5SrRNA:CR33398; 5S ribosomal RNA [KO:K01981]
Dmel_CR33410  5SrRNA:CR33410; 5S ribosomal RNA [KO:K01981]
Dmel_CR33444  5SrRNA:CR33444; 5S ribosomal RNA [KO:K01981]
Dmel_CR33450  5SrRNA:CR33450; 5S ribosomal RNA [KO:K01981]
Dmel_CR33374  5SrRNA:CR33374; 5S ribosomal RNA [KO:K01981]
Dmel_CR33373  5SrRNA:CR33373; 5S ribosomal RNA [KO:K01981]
Dmel_CR33447  5SrRNA:CR33447; 5S ribosomal RNA [KO:K01981]
Dmel_CR33452  5SrRNA:CR33452; 5S ribosomal RNA [KO:K01981]
Dmel_CR33448  5SrRNA:CR33448; 5S ribosomal RNA [KO:K01981]
Dmel_CR33394  5SrRNA:CR33394; 5S ribosomal RNA [KO:K01981]
Dmel_CR33441  5SrRNA:CR33441; 5S ribosomal RNA [KO:K01981]
Dmel_CR33407  5SrRNA:CR33407; 5S ribosomal RNA [KO:K01981]
Dmel_CR33368  5SrRNA:CR33368; 5S ribosomal RNA [KO:K01981]
Dmel_CR33405  5SrRNA:CR33405; 5S ribosomal RNA [KO:K01981]
Dmel_CR33362  5SrRNA:CR33362; 5S ribosomal RNA [KO:K01981]
Dmel_CR33421  5SrRNA:CR33421; 5S ribosomal RNA [KO:K01981]
Dmel_CR33385  5SrRNA:CR33385; 5S ribosomal RNA [KO:K01981]
Dmel_CR33404  5SrRNA:CR33404; 5S ribosomal RNA [KO:K01981]
Dmel_CR33358  5SrRNA:CR33358; 5S ribosomal RNA [KO:K01981]
Dmel_CR33387  5SrRNA:CR33387; 5S ribosomal RNA [KO:K01981]
Dmel_CR33370  5SrRNA:CR33370; 5S ribosomal RNA [KO:K01981]
Dmel_CR33413  5SrRNA:CR33413; 5S ribosomal RNA [KO:K01981]
Dmel_CR33412  5SrRNA:CR33412; 5S ribosomal RNA [KO:K01981]
Dmel_CR33377  5SrRNA:CR33377; 5S ribosomal RNA [KO:K01981]
Dmel_CR33382  5SrRNA:CR33382; 5S ribosomal RNA [KO:K01981]
Dmel_CR33391  5SrRNA:CR33391; 5S ribosomal RNA [KO:K01981]
Dmel_CR33393  5SrRNA:CR33393; 5S ribosomal RNA [KO:K01981]
Dmel_CR33446  5SrRNA:CR33446; 5S ribosomal RNA [KO:K01981]
Dmel_CR33376  5SrRNA:CR33376; 5S ribosomal RNA [KO:K01981]
Dmel_CR33428  5SrRNA:CR33428; 5S ribosomal RNA [KO:K01981]
Dmel_CR33628  snoRNA:U3:54Ab [KO:K14483]
Dmel_CR33921  snoRNA:U3:54Aa [KO:K14483]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
dme03010  Ribosome
KO pathway
ko03008   

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