KEGG   PATHWAY: dme03013
Entry
dme03013                    Pathway                                

Name
RNA transport - Drosophila melanogaster (fruit fly)
Description
RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.
Class
Genetic Information Processing; Translation
Pathway map
dme03013  RNA transport
dme03013

Other DBs
GO: 0050658
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG32763  Pop1; POP1 ribonuclease P/MRP subunit [KO:K01164] [EC:3.1.26.5]
Dmel_CG8038  Pop4; POP4 ribonuclease P/MRP subunit [KO:K03538] [EC:3.1.26.5]
Dmel_CG14057  Pop5; POP5 ribonuclease P/MRP subunit, isoform B [KO:K03537] [EC:3.1.26.5]
Dmel_CG9422  Rpp25; ribonuclease P/MRP subunit p25, isoform D [KO:K14525] [EC:3.1.26.5]
Dmel_CG33931  Rpp20; Rpp20, isoform A [KO:K14527] [EC:3.1.26.5]
Dmel_CG34317  Rpp14a; ribonuclease P/MRP subunit p14 a [KO:K14529] [EC:3.1.26.5]
Dmel_CG15526  Rpp14b; ribonuclease P/MRP subunit p14 b [KO:K14529] [EC:3.1.26.5]
Dmel_CG11606  Rpp30; RNaseP protein p30, isoform B [KO:K03539] [EC:3.1.26.5]
Dmel_CG33082  Rpp21; ribonuclease P/MRP subunit p21, isoform B [KO:K03540] [EC:3.1.26.5]
Dmel_CG3298  RNaseZ; ribonuclease Z [KO:K00784] [EC:3.1.26.11]
Dmel_CG2100  CG2100; uncharacterized protein, isoform B [KO:K00974] [EC:2.7.7.72 3.1.3.- 3.1.4.-]
Dmel_CG1404  Ran; Ran, isoform C [KO:K07936]
Dmel_CG7815  Ran-like [KO:K07936]
Dmel_CG12234  Ranbp21; Ranbp21, isoform B [KO:K14289]
Dmel_CG8280  eEF1alpha1; eukaryotic translation elongation factor 1 alpha 1, isoform D [KO:K03231]
Dmel_CG1873  eEF1alpha2; eukaryotic translation elongation factor 1 alpha 2, isoform A [KO:K03231]
Dmel_CG13387  emb; embargoed, isoform B [KO:K14290]
Dmel_CG8069  Phax; phosphorylated adaptor for RNA export, isoform A [KO:K14291]
Dmel_CG7035  Cbp80; cap binding protein 80, isoform B [KO:K12882]
Dmel_CG7907  CG7907; uncharacterized protein, isoform B [KO:K12882]
Dmel_CG12357  Cbp20; cap binding protein 20 [KO:K12883]
Dmel_CG4924  icln; icln [KO:K05019]
Dmel_CG3730  csul; capsuleen, isoform A [KO:K02516] [EC:2.1.1.320]
Dmel_CG44890  Tgs1; trimethylguanosine synthase 1 [KO:K14292] [EC:2.1.1.-]
Dmel_CG42350  moi; modigliani [KO:K14292] [EC:2.1.1.-]
Dmel_CG2637  Fs(2)Ket; female sterile (2) ketel, isoform D [KO:K14293]
Dmel_CG42303  Snup; snurportin [KO:K13151]
Dmel_CG42304  CG42304; uncharacterized protein, isoform B [KO:K13151]
Dmel_CG3460  Nmd3; Nonsense-mediated mRNA 3 [KO:K07562]
Dmel_CG30176  Pym; partner of Y14 and mago [KO:K14294]
Dmel_CG8274  Mtor; megator, isoform B [KO:K09291]
Dmel_CG2158  Nup50; nucleoporin 50kD [KO:K14295]
Dmel_CG4453  Nup153; nucleoporin 153kD, isoform C [KO:K14296]
Dmel_CG10198  Nup98-96; nucleoporin 98-96kD, isoform D [KO:K14297]
Dmel_CG9862  Rae1; Rae1 [KO:K14298]
Dmel_CG12782  CG12782; uncharacterized protein [KO:K14298]
Dmel_CG6773  Sec13; secretory 13, isoform B [KO:K14004]
Dmel_CG8722  Nup44A; nucleoporin at 44A, isoform A [KO:K14299]
Dmel_CG6958  Nup133; nucleoporin 133kD [KO:K14300]
Dmel_CG6743  Nup107; nucleoporin 107kD [KO:K14301]
Dmel_CG11875  Nup37; nucleoporin 37kD, isoform B [KO:K14302]
Dmel_CG4738  Nup160; nucleoporin 160kD, isoform B [KO:K14303]
Dmel_CG5733  Nup75; nucleoporin 75kD [KO:K14304]
Dmel_CG7671  Nup43; nucleoporin 43kD [KO:K14305]
Dmel_CG6251  Nup62; nucleoporin 62kD, isoform B [KO:K14306]
Dmel_CG7360  Nup58; nucleoporin 58kD [KO:K14307]
Dmel_CG8831  Nup54; nucleoporin 54kD [KO:K14308]
Dmel_CG7262  Nup93-2; nucleoporin 93kD-2 [KO:K14309]
Dmel_CG11092  Nup93-1; nucleoporin 93kD-1 [KO:K14309]
Dmel_CG11943  Nup205; nucleoporin 205kD, isoform B [KO:K14310]
Dmel_CG8771  Nup188; nucleoporin 188kDa, isoform C [KO:K14311]
Dmel_CG4579  Nup154; nucleoporin 154kD, isoform D [KO:K14312]
Dmel_CG6540  Nup35; nucleoporin 35kDa [KO:K14313]
Dmel_CG7897  Gp210; glycoprotein 210 kDa, isoform B [KO:K14314]
Dmel_CG5857  Ndc1; nuclear division cycle 1 [KO:K14315]
Dmel_CG14712  CG14712; uncharacterized protein [KO:K14316]
Dmel_CG3820  Nup214; nucleoporin 214kD [KO:K14317]
Dmel_CG6819  mbo; members only [KO:K14318]
Dmel_CG11856  Nup358; nucleoporin 358kD, isoform B [KO:K12172] [EC:2.3.2.-]
Dmel_CG9999  RanGAP; Ran GTPase activating protein, isoform B [KO:K14319]
Dmel_CG3018  lwr; lesswright, isoform C [KO:K10577]
Dmel_CG4494  smt3; smt3, isoform B [KO:K12160]
Dmel_CG43069  CG43069; uncharacterized protein [KO:K12160]
Dmel_CG16892  Aladin; aladin, isoform B [KO:K14320]
Dmel_CG13137  CG13137; uncharacterized protein [KO:K14320]
Dmel_CG18789  CG18789; uncharacterized protein [KO:K14321]
Dmel_CG18787  CG18787; uncharacterized protein [KO:K14321]
Dmel_CG16725  Smn; survival motor neuron, isoform B [KO:K13129]
Dmel_CG10419  Gem2; gemin 2, isoform B [KO:K13130]
Dmel_CG6539  Gem3; gemin 3, isoform B [KO:K13131] [EC:3.6.4.13]
Dmel_CG3957  wmd; wing morphogenesis defect, isoform B [KO:K13137]
Dmel_CG10459  CG10459; uncharacterized protein [KO:K13137]
Dmel_CG12131  eIF3j; eukaryotic translation initiation factor 3 subunit j, isoform B [KO:K03245]
Dmel_CG8882  eIF3i; eukaryotic translation initiation factor 3 subunit i [KO:K03246]
Dmel_CG9124  eIF3h; eukaryotic translation initiation factor 3 subunit h, isoform A [KO:K03247]
Dmel_CG8636  eIF3g1; eukaryotic translation initiation factor 3 subunit g1 [KO:K03248]
Dmel_CG10881  eIF3g2; eukaryotic translation initiation factor 3 subunit g2 [KO:K03248]
Dmel_CG9769  eIF3f1; eukaryotic translation initiation factor 3 subunit f1 [KO:K03249]
Dmel_CG8335  eIF3f2; eukaryotic translation initiation factor 3 subunit f2 [KO:K03249]
Dmel_CG9677  eIF3e; eukaryotic translation initiation factor 3 subunit e [KO:K03250]
Dmel_CG4810  eIF3d2; eukaryotic translation initiation factor 3 subunit d2 [KO:K03251]
Dmel_CG10161  eIF3d1; eukaryotic translation initiation factor 3 subunit d1 [KO:K03251]
Dmel_CG4954  eIF3c; eukaryotic translation initiation factor 3 subunit c, isoform B [KO:K03252]
Dmel_CG4878  eIF3b; eukaryotic translation initiation factor 3 subunit b, isoform B [KO:K03253]
Dmel_CG9805  eIF3a; eukaryotic translation initiation factor 3 subunit a, isoform A [KO:K03254]
Dmel_CG8053  eIF1A; eukaryotic translation initiation factor 1A, isoform C [KO:K03236]
Dmel_CG17737  eIF1; eukaryotic translation initiation factor 1 [KO:K03113]
Dmel_CG9177  eIF5; eukaryotic translation initiation factor 5, isoform B [KO:K03262]
Dmel_CG9946  eIF2alpha; eukaryotic translation initiation factor 2 subunit alpha, isoform B [KO:K03237]
Dmel_CG4153  eIF2beta; eukaryotic translation initiation factor 2 subunit beta [KO:K03238]
Dmel_CG7883  eIF2Balpha; eukaryotic translation initiation factor 2B subunit alpha [KO:K03239]
Dmel_CG2677  eIF2Bbeta; eukaryotic translation initiation factor 2B subunit beta [KO:K03754]
Dmel_CG10315  eIF2Bdelta; eukaryotic translation initiation factor 2B subunit delta, isoform D [KO:K03680]
Dmel_CG8190  eIF2Bgamma; eukaryotic translation initiation factor 2B subunit gamma [KO:K03241]
Dmel_CG3806  eIF2Bepsilon; eukaryotic translation initiation factor 2B subunit epsilon, isoform A [KO:K03240]
Dmel_CG10840  eIF5B; eukaryotic translation initiation factor 5B, isoform C [KO:K03243]
Dmel_CG10811  eIF4G1; eukaryotic translation initiation factor 4G1, isoform B [KO:K03260]
Dmel_CG3845  NAT1; NAT1, isoform D [KO:K03260]
Dmel_CG1442  eIF4E6; eukaryotic translation initiation factor 4E6, isoform B [KO:K03259]
Dmel_CG10124  eIF4E4; eukaryotic translation initiation factor 4E4 [KO:K03259]
Dmel_CG4035  eIF4E1; eukaryotic translation initiation factor 4E1, isoform H [KO:K03259]
Dmel_CG33100  eIF4EHP; eukaryotic translation initiation factor 4E homologous protein, isoform B [KO:K03259]
Dmel_CG8023  eIF4E3; eukaryotic translation initiation factor 4E3 [KO:K03259]
Dmel_CG32859  eIF4E7; eukaryotic translation initiation factor 4E7 [KO:K03259]
Dmel_CG8277  eIF4E5; eukaryotic translation initiation factor 4E5 [KO:K03259]
Dmel_CG9075  eIF4A; eukaryotic translation initiation factor 4A, isoform E [KO:K03257]
Dmel_CG10837  eIF4B; eukaryotic translation initiation factor 4B, isoform B [KO:K03258]
Dmel_CG5119  pAbp; poly(A) binding protein, isoform A [KO:K13126]
Dmel_CG8963  CG8963; uncharacterized protein, isoform C [KO:K14322]
Dmel_CG8846  Thor; thor, isoform B [KO:K18644]
Dmel_CG9765  tacc; transforming acidic coiled-coil protein, isoform H [KO:K14283]
Dmel_CG4931  Sra-1; specifically Rac1-associated protein 1 [KO:K05749]
Dmel_CG6203  Fmr1; Fmr1, isoform A [KO:K15516]
Dmel_CG8781  tsu; tsunagi [KO:K12876]
Dmel_CG9401  mago; mago nashi [KO:K12877]
Dmel_CG12878  btz; barentsz, isoform C [KO:K14323]
Dmel_CG7483  CG7483; uncharacterized protein [KO:K13025] [EC:3.6.4.13]
Dmel_CG6046  Bin1; bicoid interacting protein 1, isoform B [KO:K14324]
Dmel_CG8383  Pnn; pinin, isoform B [KO:K13114]
Dmel_CG10473  Acn; acinus, isoform C [KO:K12875]
Dmel_CG34334  CG34334; uncharacterized protein [KO:K14325]
Dmel_CG16788  RnpS1; RNA-binding protein S1 [KO:K14325]
Dmel_CG1101  Ref1; RNA and export factor binding protein 1 [KO:K12881]
Dmel_CG17031  Ref2; RNA and export factor binding protein 2, isoform B [KO:K12881]
Dmel_CG7269  Hel25E; helicase at 25E, isoform A [KO:K12812] [EC:3.6.4.13]
Dmel_CG2031  Hpr1; Hpr1 [KO:K12878]
Dmel_CG31671  tho2; tho2, isoform C [KO:K12879]
Dmel_CG2980  thoc5; thoc5 [KO:K13174]
Dmel_CG5632  thoc6; thoc6, isoform B [KO:K13175]
Dmel_CG17143  thoc7; thoc7, isoform A [KO:K13176]
Dmel_CG9615  tex; tex [KO:K12880]
Dmel_CG11274  Srrm1; Serine-arginine repetitive matrix 1 [KO:K13171]
Dmel_CG1664  sbr; small bristles, isoform A [KO:K14284]
Dmel_CG32135  Nxf3; nuclear export factor 3, isoform E [KO:K14284]
Dmel_CG31501  nxf4; nuclear export factor 4 [KO:K14284]
Dmel_CG12752  Nxt1; NTF2-related export protein 1, isoform A [KO:K14285]
Dmel_CG1559  Upf1; Upf1 RNA helicase, isoform B [KO:K14326] [EC:3.6.4.-]
Dmel_CG2253  Upf2; Upf2 [KO:K14327]
Dmel_CG11184  Upf3; Upf3, isoform D [KO:K14328]
Dmel_CR31341  snRNA:U1:95Ca; small nuclear RNA U1 at 95C a [KO:K14276]
Dmel_CR31854  snRNA:U2:34ABb; small nuclear RNA U2 at 34AB b [KO:K14277]
Dmel_CR31850  snRNA:U2:34ABa; small nuclear RNA U2 at 34AB a [KO:K14277]
Dmel_CR33788  snRNA:U2:34ABc; small nuclear RNA U2 at 34AB c [KO:K14277]
Dmel_CR32882  snRNA:U2:38ABa; small nuclear RNA U2 at 38AB a [KO:K14277]
Dmel_CR32913  snRNA:U2:14B; small nuclear RNA U2 at 14B [KO:K14277]
Dmel_CR32878  snRNA:U2:38ABb; small nuclear RNA U2 at 38AB b [KO:K14277]
Dmel_CR31625  snRNA:U4:39B; small nuclear RNA U4 at 39B [KO:K14278]
Dmel_CR32879  snRNA:U4:38AB; small nuclear RNA U4 at 38AB [KO:K14278]
Dmel_CR32881  snRNA:U5:38ABa; small nuclear RNA U5 at 38AB a [KO:K14279]
Dmel_CR32880  snRNA:U5:38ABb; small nuclear RNA U5 at 38AB b [KO:K14279]
Dmel_CR32914  snRNA:U5:14B; small nuclear RNA U5 at 14B [KO:K14279]
Dmel_CR31379  snRNA:U6:96Aa; small nuclear RNA U6 at 96A a [KO:K14280]
Dmel_CR32867  snRNA:U6:96Ab; small nuclear RNA U6 at 96A b [KO:K14280]
Dmel_CR31539  snRNA:U6:96Ac; small nuclear RNA U6 at 96A c [KO:K14280]
Dmel_CR33628  snoRNA:U3:54Ab [KO:K14483]
Dmel_CR33921  snoRNA:U3:54Aa [KO:K14483]
Compound
C00035  GDP
C00044  GTP
C01647  tRNA(Met)
Reference
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
  Authors
Suzuki T, Izumi H, Ohno M
  Title
Cajal body surveillance of U snRNA export complex assembly.
  Journal
J Cell Biol 190:603-12 (2010)
DOI:10.1083/jcb.201004109
Reference
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
  Authors
Pellizzoni L
  Title
Chaperoning ribonucleoprotein biogenesis in health and disease.
  Journal
EMBO Rep 8:340-5 (2007)
DOI:10.1038/sj.embor.7400941
Reference
  Authors
Gingras AC, Raught B, Sonenberg N
  Title
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
  Journal
Annu Rev Biochem 68:913-63 (1999)
DOI:10.1146/annurev.biochem.68.1.913
Reference
  Authors
Asano K, Clayton J, Shalev A, Hinnebusch AG
  Title
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
  Journal
Genes Dev 14:2534-46 (2000)
DOI:10.1101/gad.831800
Reference
PMID:9548260
  Authors
Craig AW, Haghighat A, Yu AT, Sonenberg N
  Title
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
  Journal
Nature 392:520-3 (1998)
DOI:10.1038/33198
Reference
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Related
pathway
dme03008  Ribosome biogenesis in eukaryotes
dme03010  Ribosome
dme03015  mRNA surveillance pathway
dme03020  RNA polymerase
dme03040  Spliceosome
KO pathway
ko03013   

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