KEGG   PATHWAY: dme03013
Entry
dme03013                    Pathway                                
Name
Nucleocytoplasmic transport - Drosophila melanogaster (fruit fly)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
dme03013  Nucleocytoplasmic transport
dme03013

Other DBs
GO: 0050658
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG10198  Nup98-96; nucleoporin 98-96kD, isoform D [KO:K14297]
Dmel_CG10473  Acn; acinus, isoform C [KO:K12875]
Dmel_CG10478  alphaKap4; alpha Karyopherin-4 [KO:K23583]
Dmel_CG1059  Karybeta3; karyopherin beta 3, isoform B [KO:K20222]
Dmel_CG10950  CG10950; uncharacterized protein [KO:K15436]
Dmel_CG1101  Ref1; RNA and export factor binding protein 1 [KO:K12881]
Dmel_CG11092  Nup93-1; nucleoporin 93kD-1 [KO:K14309]
Dmel_CG11184  Upf3; Upf3, isoform D [KO:K14328]
Dmel_CG11274  Srrm1; Serine-arginine repetitive matrix 1 [KO:K13171]
Dmel_CG11856  Nup358; nucleoporin 358kD, isoform B [KO:K12172] [EC:2.3.2.-]
Dmel_CG11875  Nup37; nucleoporin 37kD, isoform B [KO:K14302]
Dmel_CG11943  Nup205; nucleoporin 205kD, isoform B [KO:K14310]
Dmel_CG12234  Ranbp21; Ranbp21, isoform B [KO:K14289]
Dmel_CG12357  Cbp20; cap binding protein 20 [KO:K12883]
Dmel_CG12752  Nxt1; NTF2-related export protein 1, isoform A [KO:K14285]
Dmel_CG12782  CG12782; uncharacterized protein [KO:K14298]
Dmel_CG12878  btz; barentsz, isoform C [KO:K14323]
Dmel_CG13137  CG13137; uncharacterized protein [KO:K14320]
Dmel_CG13281  Cse1; chromosome segregation 1 [KO:K18423]
Dmel_CG13387  emb; embargoed, isoform B [KO:K14290]
Dmel_CG1404  Ran; Ran, isoform C [KO:K07936]
Dmel_CG14215  Elys; elys, isoform B [KO:K25129]
Dmel_CG14712  CG14712; uncharacterized protein [KO:K14316]
Dmel_CG14749  Gle1; Gle1 RNA export mediator [KO:K18723]
Dmel_CG1559  Upf1; Upf1 RNA helicase, isoform B [KO:K14326] [EC:5.6.2.5 5.6.2.3]
Dmel_CG1664  sbr; small bristles, isoform A [KO:K14284]
Dmel_CG16788  RnpS1; RNA-binding protein S1 [KO:K14325]
Dmel_CG16892  Aladin; aladin, isoform B [KO:K14320]
Dmel_CG17023  Dbp80; dead box protein 80, isoform B [KO:K18655] [EC:5.6.2.7]
Dmel_CG17031  Ref2; RNA and export factor binding protein 2, isoform B [KO:K12881]
Dmel_CG17143  thoc7; thoc7, isoform A [KO:K13176]
Dmel_CG1873  eEF1alpha2; eukaryotic translation elongation factor 1 alpha 2, isoform A [KO:K03231]
Dmel_CG18787  CG18787; uncharacterized protein [KO:K14321]
Dmel_CG18789  CG18789; uncharacterized protein [KO:K14321]
Dmel_CG2031  Hpr1; Hpr1 [KO:K12878]
Dmel_CG2158  Nup50; nucleoporin 50kD [KO:K14295]
Dmel_CG2253  Upf2; Upf2 [KO:K14327]
Dmel_CG2637  Fs(2)Ket; female sterile (2) ketel, isoform D [KO:K14293]
Dmel_CG2848  Tnpo-SR; Transportin-Serine/Arginine rich, isoform B [KO:K15436]
Dmel_CG2980  thoc5; thoc5 [KO:K13174]
Dmel_CG30176  Pym; partner of Y14 and mago [KO:K14294]
Dmel_CG3018  lwr; lesswright, isoform C [KO:K10577]
Dmel_CG31501  nxf4; nuclear export factor 4 [KO:K14284]
Dmel_CG31671  tho2; tho2, isoform C [KO:K12879]
Dmel_CG32135  Nxf3; nuclear export factor 3, isoform E [KO:K14284]
Dmel_CG32164  Arts; artemis, isoform B [KO:K20221]
Dmel_CG32165  Apl; apollo, isoform B [KO:K20221]
Dmel_CG33139  Impbeta11; importin beta11 [KO:K25201]
Dmel_CG33180  Ranbp16; Ranbp16, isoform H [KO:K18460]
Dmel_CG34334  CG34334; uncharacterized protein [KO:K14325]
Dmel_CG3460  Nmd3; Nonsense-mediated mRNA 3 [KO:K07562]
Dmel_CG3820  Nup214; nucleoporin 214kD [KO:K14317]
Dmel_CG3923  ebo; ellipsoid body open, isoform B [KO:K25204]
Dmel_CG42303  Snup; snurportin [KO:K13151]
Dmel_CG42304  CG42304; uncharacterized protein, isoform B [KO:K13151]
Dmel_CG4453  Nup153; nucleoporin 153kD, isoform C [KO:K14296]
Dmel_CG4494  Sumo; small ubiquitin like modifier, isoform B [KO:K12160]
Dmel_CG4579  Nup154; nucleoporin 154kD, isoform D [KO:K14312]
Dmel_CG4738  Nup160; nucleoporin 160kD, isoform B [KO:K14303]
Dmel_CG4799  Pen; pendulin [KO:K15043]
Dmel_CG5252  Ipo9; importin 9, isoform D [KO:K20224]
Dmel_CG5632  thoc6; thoc6, isoform B [KO:K13175]
Dmel_CG5733  Nup75; nucleoporin 75kD [KO:K14304]
Dmel_CG5857  Ndc1; nuclear division cycle 1 [KO:K14315]
Dmel_CG6046  Bin1; bicoid interacting protein 1, isoform B [KO:K14324]
Dmel_CG6251  Nup62; nucleoporin 62kD, isoform B [KO:K14306]
Dmel_CG6540  Nup35; nucleoporin 35kDa [KO:K14313]
Dmel_CG6743  Nup107; nucleoporin 107kD [KO:K14301]
Dmel_CG6773  Sec13; secretory 13, isoform B [KO:K14004]
Dmel_CG6819  mbo; members only [KO:K14318]
Dmel_CG6958  Nup133; nucleoporin 133kD [KO:K14300]
Dmel_CG7035  Cbp80; cap binding protein 80, isoform B [KO:K12882]
Dmel_CG7212  cdm; cadmus, isoform B [KO:K25202]
Dmel_CG7262  Nup93-2; nucleoporin 93kD-2 [KO:K14309]
Dmel_CG7269  Hel25E; helicase at 25E, isoform A [KO:K12812] [EC:5.6.2.7]
Dmel_CG7360  Nup58; nucleoporin 58kD [KO:K14307]
Dmel_CG7398  Tnpo; transportin, isoform D [KO:K18752]
Dmel_CG7483  CG7483; uncharacterized protein [KO:K13025] [EC:5.6.2.7]
Dmel_CG7671  Nup43; nucleoporin 43kD [KO:K14305]
Dmel_CG7815  [KO:K07936]
Dmel_CG7897  Gp210; glycoprotein 210 kDa, isoform B [KO:K14314]
Dmel_CG7907  CG7907; uncharacterized protein, isoform B [KO:K12882]
Dmel_CG7935  msk; moleskin [KO:K20223]
Dmel_CG8069  Phax; phosphorylated adaptor for RNA export, isoform A [KO:K14291]
Dmel_CG8219  CG8219; uncharacterized protein [KO:K18752]
Dmel_CG8274  Mgtor; megator, isoform B [KO:K09291]
Dmel_CG8280  eEF1alpha1; eukaryotic translation elongation factor 1 alpha 1, isoform D [KO:K03231]
Dmel_CG8383  Pnn; pinin, isoform B [KO:K13114]
Dmel_CG8548  Kap-alpha1; karyopherin alpha1 [KO:K15042]
Dmel_CG8722  Nup44A; nucleoporin at 44A, isoform A [KO:K14299]
Dmel_CG8771  Nup188; nucleoporin 188kDa, isoform C [KO:K14311]
Dmel_CG8781  tsu; tsunagi [KO:K12876]
Dmel_CG8831  Nup54; nucleoporin 54kD [KO:K14308]
Dmel_CG9159  Kr-h2; kruppel homolog 2, isoform B [KO:K20724]
Dmel_CG9401  mago; mago nashi [KO:K12877]
Dmel_CG9423  Kap-alpha3; karyopherin alpha3, isoform D [KO:K23583]
Dmel_CG9615  tex; tex [KO:K12880]
Dmel_CG9862  Rae1; Rae1 [KO:K14298]
Dmel_CG9999  RanGAP; Ran GTPase activating protein, isoform B [KO:K14319]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
dme03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
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