KEGG   PATHWAY: dme03460
Entry
dme03460                    Pathway                                
Name
Fanconi anemia pathway - Drosophila melanogaster (fruit fly)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
dme03460  Fanconi anemia pathway
dme03460

Other DBs
GO: 0043240
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG4252  mei-41; meiotic 41 [KO:K06640] [EC:2.7.11.1]
Dmel_CG7922  Fancm; fanconi anemia group M helicase, isoform B [KO:K10896]
Dmel_CG12812  Fancl; fancl, isoform A [KO:K10606] [EC:2.3.2.27]
Dmel_CG9062  CG9062; uncharacterized protein, isoform B [KO:K15361]
Dmel_CG15817  Usp1; ubiquitin specific protease 1, isoform E [KO:K11832] [EC:3.4.19.12]
Dmel_CG13745  FANCI; fanconi anemia complementation group I [KO:K10895]
Dmel_CG17269  Fancd2; Fancd2 [KO:K10891]
Dmel_CG31069  spn-D; spindle D [KO:K10870]
Dmel_CG7948  spn-A; spindle A, isoform A [KO:K04482]
Dmel_CG11482  Mlh1; Mlh1, isoform B [KO:K08734]
Dmel_CG8169  Pms2; Pms2 [KO:K10858]
Dmel_CG12189  Rev1; DNA polymerase Rev1 [KO:K03515] [EC:2.7.7.-]
Dmel_CG1925  PolZ1; DNA polymerase zeta subunit 1 [KO:K02350] [EC:2.7.7.7]
Dmel_CG7143  PolH; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
Dmel_CG7602  PolI; DNA polymerase iota, isoform C [KO:K03510] [EC:2.7.7.7]
Dmel_CG3458  Top3beta; topoisomerase 3beta, isoform B [KO:K03165] [EC:5.6.2.1]
Dmel_CG10123  Top3alpha; topoisomerase 3alpha [KO:K03165] [EC:5.6.2.1]
Dmel_CG6920  Blm; bloom syndrome helicase [KO:K10901] [EC:5.6.2.4]
Dmel_CG9633  RPA1; replication protein A1 [KO:K07466]
Dmel_CG9273  RPA2; replication protein A2, isoform B [KO:K10739]
Dmel_CG15220  RPA3; replication protein A3, isoform B [KO:K10740]
Dmel_CG3026  mus81; mus81 [KO:K08991] [EC:3.1.22.-]
Dmel_CG12936  mms4; methyl methanesulfonate sensitivity 4 [KO:K10882] [EC:3.1.22.-]
Dmel_CG3697  mei-9; meiotic 9, isoform B [KO:K10848] [EC:3.1.-.-]
Dmel_CG10215  Ercc1; Ercc1 [KO:K10849]
Dmel_CG18271  slx1; nuclease slx1 [KO:K15078] [EC:3.6.1.-]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
dme03430  Mismatch repair
dme03440  Homologous recombination
KO pathway
ko03460   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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