KEGG   PATHWAY: dpo03018
Entry
dpo03018                    Pathway                                

Name
RNA degradation - Drosophila pseudoobscura pseudoobscura
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dpo03018  RNA degradation
dpo03018

Other DBs
GO: 0006401
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA15233  uncharacterized protein [KO:K12584] [EC:3.6.1.59]
Dpse_GA19469  uncharacterized protein [KO:K07573]
Dpse_GA17783  uncharacterized protein [KO:K03679]
Dpse_GA16580  uncharacterized protein [KO:K03681]
Dpse_GA20773  uncharacterized protein [KO:K12587]
Dpse_GA21043  uncharacterized protein [KO:K12589]
Dpse_GA13761  uncharacterized protein [KO:K11600]
Dpse_GA17911  uncharacterized protein [KO:K12590]
Dpse_GA21908  uncharacterized protein [KO:K03678]
Dpse_GA19573  uncharacterized protein [KO:K12585] [EC:3.1.13.-]
Dpse_GA20243  uncharacterized protein [KO:K12591] [EC:3.1.13.-]
Dpse_GA25611  uncharacterized protein [KO:K12592]
Dpse_GA32946  uncharacterized protein [KO:K12592]
Dpse_GA21645  uncharacterized protein [KO:K12593]
Dpse_GA10875  uncharacterized protein [KO:K03514] [EC:2.7.7.19]
Dpse_GA14518  uncharacterized protein [KO:K03514] [EC:2.7.7.19]
Dpse_GA17990  uncharacterized protein [KO:K12598] [EC:3.6.4.13]
Dpse_GA10159  uncharacterized protein [KO:K12599] [EC:3.6.4.-]
Dpse_GA24845  uncharacterized protein [KO:K12600]
Dpse_GA17766  uncharacterized protein [KO:K12602]
Dpse_GA16037  uncharacterized protein, isoform G [KO:K12603] [EC:3.1.13.4]
Dpse_GA30445  uncharacterized protein [KO:K12604]
Dpse_GA15276  uncharacterized protein, isoform C [KO:K12605]
Dpse_GA13611  uncharacterized protein [KO:K12605]
Dpse_GA21070  uncharacterized protein, isoform A [KO:K12580]
Dpse_GA28160  uncharacterized protein [KO:K10643] [EC:2.3.2.27]
Dpse_GA19054  uncharacterized protein, isoform C [KO:K12581]
Dpse_GA12828  uncharacterized protein, isoform A [KO:K12606]
Dpse_GA27260  uncharacterized protein [KO:K12606]
Dpse_GA15014  uncharacterized protein [KO:K12607]
Dpse_GA21700  uncharacterized protein [KO:K14442] [EC:3.6.4.13]
Dpse_GA21619  uncharacterized protein, isoform A [KO:K14443]
Dpse_GA18673  uncharacterized protein, isoform A [KO:K13126]
Dpse_GA20915  uncharacterized protein, isoform A [KO:K12571] [EC:3.1.13.4]
Dpse_GA11027  uncharacterized protein, isoform A [KO:K12572]
Dpse_GA10823  uncharacterized protein [KO:K12611] [EC:3.-.-.-]
Dpse_GA19405  uncharacterized protein [KO:K12613] [EC:3.6.1.62]
Dpse_GA19506  uncharacterized protein, isoform A [KO:K12615]
Dpse_GA19417  uncharacterized protein [KO:K12616]
Dpse_GA18738  uncharacterized protein [KO:K12617]
Dpse_GA17195  uncharacterized protein [KO:K12618] [EC:3.1.13.-]
Dpse_GA10268  uncharacterized protein [KO:K12619] [EC:3.1.13.-]
Dpse_GA18077  uncharacterized protein [KO:K12620]
Dpse_GA10305  uncharacterized protein [KO:K12621]
Dpse_GA29226  uncharacterized protein [KO:K12622]
Dpse_GA29224  uncharacterized protein, isoform B [KO:K12622]
Dpse_GA30187  uncharacterized protein, isoform B [KO:K12622]
Dpse_GA22792  uncharacterized protein [KO:K12623]
Dpse_GA19721  uncharacterized protein [KO:K12624]
Dpse_GA21716  uncharacterized protein [KO:K12625]
Dpse_GA12164  uncharacterized protein [KO:K12626]
Dpse_GA15189  uncharacterized protein [KO:K12627]
Dpse_GA14598  Dpse_Eno; Eno [KO:K01689] [EC:4.2.1.11]
Dpse_GA10930  uncharacterized protein [KO:K00962] [EC:2.7.7.8]
Dpse_GA17840  uncharacterized protein, isoform A [KO:K00850] [EC:2.7.1.11]
Dpse_GA21150  uncharacterized protein [KO:K04043]
Dpse_GA22684  uncharacterized protein [KO:K04077]
Dpse_GA28835  uncharacterized protein [KO:K04077]
Dpse_GA25838  uncharacterized protein [KO:K04077]
Dpse_GA22285  uncharacterized protein, isoform A [KO:K04077]
Dpse_GA14234  uncharacterized protein [KO:K04077]
Reference
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
DOI:10.1016/j.cell.2009.01.019
Reference
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
DOI:10.1111/j.1365-2958.2006.05331.x
Reference
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
DOI:10.1016/S0074-7696(06)51005-8
Reference
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
DOI:10.1038/sj.embor.7400961
Reference
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
DOI:10.1146/annurev.micro.61.080706.093440
Reference
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
DOI:10.1016/j.tibs.2006.05.005
Reference
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
DOI:10.1016/j.mib.2007.05.008
Related
pathway
dpo03015  mRNA surveillance pathway
KO pathway
ko03018   

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