KEGG   PATHWAY: dpo03030
Entry
dpo03030                    Pathway                                

Name
DNA replication - Drosophila pseudoobscura pseudoobscura
Description
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
Class
Genetic Information Processing; Replication and repair
Pathway map
dpo03030  DNA replication
dpo03030

Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA18119  uncharacterized protein [KO:K03111]
Dpse_GA21286  uncharacterized protein, isoform E [KO:K03469] [EC:3.1.26.4]
Dpse_GA21928  uncharacterized protein [KO:K07466]
Dpse_GA21602  uncharacterized protein [KO:K04802]
Dpse_GA10201  uncharacterized protein [KO:K04802]
Dpse_GA15562  uncharacterized protein [KO:K10742] [EC:3.6.4.12]
Dpse_GA27689  uncharacterized protein [KO:K04799] [EC:3.-.-.-]
Dpse_GA18999  uncharacterized protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Dpse_GA19530  uncharacterized protein [KO:K02320] [EC:2.7.7.7]
Dpse_GA19232  uncharacterized protein [KO:K02321]
Dpse_GA20108  uncharacterized protein, isoform A [KO:K02684] [EC:2.7.7.102]
Dpse_GA18964  uncharacterized protein [KO:K02685]
Dpse_GA19253  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dpse_GA11341  uncharacterized protein [KO:K02328]
Dpse_GA17815  uncharacterized protein [KO:K03504]
Dpse_GA19850  uncharacterized protein [KO:K02324] [EC:2.7.7.7]
Dpse_GA10347  uncharacterized protein [KO:K02325] [EC:2.7.7.7]
Dpse_GA17216  uncharacterized protein [KO:K02326] [EC:2.7.7.7]
Dpse_GA10901  uncharacterized protein [KO:K03506] [EC:2.7.7.7]
Dpse_GA20424  uncharacterized protein [KO:K02540] [EC:3.6.4.12]
Dpse_GA18030  uncharacterized protein [KO:K02541] [EC:3.6.4.12]
Dpse_GA14047  uncharacterized protein [KO:K02212] [EC:3.6.4.12]
Dpse_GA17943  uncharacterized protein [KO:K02209] [EC:3.6.4.12]
Dpse_GA17904  uncharacterized protein [KO:K02542] [EC:3.6.4.12]
Dpse_GA18569  uncharacterized protein [KO:K02210] [EC:3.6.4.12]
Dpse_GA21663  uncharacterized protein [KO:K10739]
Dpse_GA13581  uncharacterized protein [KO:K10740]
Dpse_GA10826  uncharacterized protein [KO:K10754]
Dpse_GA20846  uncharacterized protein [KO:K10755]
Dpse_GA13416  uncharacterized protein [KO:K10755]
Dpse_GA19473  uncharacterized protein [KO:K10756]
Dpse_GA25212  uncharacterized protein [KO:K10756]
Dpse_GA12461  uncharacterized protein [KO:K10743] [EC:3.1.26.4]
Dpse_GA10809  uncharacterized protein [KO:K10744]
Dpse_GA15653  uncharacterized protein [KO:K10745]
Reference
PMID:8087839
  Authors
Stillman B.
  Title
Smart machines at the DNA replication fork.
  Journal
Cell 78:725-8 (1994)
DOI:10.1016/S0092-8674(94)90362-X
Reference
PMID:9759502
  Authors
Waga S, Stillman B.
  Title
The DNA replication fork in eukaryotic cells.
  Journal
Annu Rev Biochem 67:721-51 (1998)
DOI:10.1146/annurev.biochem.67.1.721
KO pathway
ko03030   

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