KEGG   PATHWAY: dpo03420
dpo03420                    Pathway                                

Nucleotide excision repair - Drosophila pseudoobscura pseudoobscura
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Pathway map
dpo03420  Nucleotide excision repair

Other DBs
GO: 0006289
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Dpse_GA14260  uncharacterized protein [KO:K03868] [EC:]
Dpse_GA22841  uncharacterized protein [KO:K03868] [EC:]
Dpse_GA23017  uncharacterized protein [KO:K03868] [EC:]
Dpse_GA24410  uncharacterized protein [KO:K03868] [EC:]
Dpse_GA21273  uncharacterized protein, isoform A [KO:K10609]
Dpse_GA20574  uncharacterized protein [KO:K10610]
Dpse_GA20854  uncharacterized protein [KO:K10838]
Dpse_GA14903  uncharacterized protein [KO:K10839]
Dpse_GA10501  uncharacterized protein [KO:K10839]
Dpse_GA17354  uncharacterized protein [KO:K02202] [EC:]
Dpse_GA20481  uncharacterized protein [KO:K10842]
Dpse_GA20328  uncharacterized protein [KO:K06634]
Dpse_GA20769  uncharacterized protein [KO:K10843] [EC:]
Dpse_GA25100  uncharacterized protein [KO:K10844] [EC:]
Dpse_GA28879  uncharacterized protein [KO:K10845]
Dpse_GA20852  uncharacterized protein, isoform A [KO:K03141]
Dpse_GA10767  uncharacterized protein, isoform A [KO:K03142]
Dpse_GA18615  uncharacterized protein [KO:K03143]
Dpse_GA22626  uncharacterized protein [KO:K03143]
Dpse_GA20571  uncharacterized protein [KO:K03144]
Dpse_GA25201  uncharacterized protein, isoform A [KO:K10846]
Dpse_GA19537  uncharacterized protein [KO:K10847]
Dpse_GA21928  uncharacterized protein [KO:K07466]
Dpse_GA21663  uncharacterized protein [KO:K10739]
Dpse_GA13581  uncharacterized protein [KO:K10740]
Dpse_GA17620  uncharacterized protein, isoform A [KO:K10848] [EC:3.1.-.-]
Dpse_GA10163  uncharacterized protein [KO:K10849]
Dpse_GA19253  uncharacterized protein [KO:K02327] [EC:]
Dpse_GA11341  uncharacterized protein [KO:K02328]
Dpse_GA17815  uncharacterized protein [KO:K03504]
Dpse_GA19850  uncharacterized protein [KO:K02324] [EC:]
Dpse_GA10347  uncharacterized protein [KO:K02325] [EC:]
Dpse_GA17216  uncharacterized protein [KO:K02326] [EC:]
Dpse_GA10901  uncharacterized protein [KO:K03506] [EC:]
Dpse_GA21602  uncharacterized protein [KO:K04802]
Dpse_GA10201  uncharacterized protein [KO:K04802]
Dpse_GA10826  uncharacterized protein [KO:K10754]
Dpse_GA20846  uncharacterized protein [KO:K10755]
Dpse_GA13416  uncharacterized protein [KO:K10755]
Dpse_GA19473  uncharacterized protein [KO:K10756]
Dpse_GA25212  uncharacterized protein [KO:K10756]
Dpse_GA18999  uncharacterized protein [KO:K10747] [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome] Japanese
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
dpo03020  RNA polymerase
dpo04120  Ubiquitin mediated proteolysis
KO pathway

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