KEGG   PATHWAY: dpo03420
Entry
dpo03420                    Pathway                                

Name
Nucleotide excision repair - Drosophila pseudoobscura pseudoobscura
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
dpo03420  Nucleotide excision repair
dpo03420

Other DBs
GO: 0006289
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA14260  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA22841  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA23017  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA24410  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA21273  uncharacterized protein, isoform A [KO:K10609]
Dpse_GA20574  uncharacterized protein [KO:K10610]
Dpse_GA20854  uncharacterized protein [KO:K10838]
Dpse_GA14903  uncharacterized protein [KO:K10839]
Dpse_GA10501  uncharacterized protein [KO:K10839]
Dpse_GA17354  uncharacterized protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
Dpse_GA20481  uncharacterized protein [KO:K10842]
Dpse_GA20328  uncharacterized protein [KO:K06634]
Dpse_GA20769  uncharacterized protein [KO:K10843] [EC:3.6.4.12]
Dpse_GA25100  uncharacterized protein [KO:K10844] [EC:3.6.4.12]
Dpse_GA28879  uncharacterized protein [KO:K10845]
Dpse_GA20852  uncharacterized protein, isoform A [KO:K03141]
Dpse_GA10767  uncharacterized protein, isoform A [KO:K03142]
Dpse_GA18615  uncharacterized protein [KO:K03143]
Dpse_GA22626  uncharacterized protein [KO:K03143]
Dpse_GA20571  uncharacterized protein [KO:K03144]
Dpse_GA25201  uncharacterized protein, isoform A [KO:K10846]
Dpse_GA19537  uncharacterized protein [KO:K10847]
Dpse_GA21928  uncharacterized protein [KO:K07466]
Dpse_GA21663  uncharacterized protein [KO:K10739]
Dpse_GA13581  uncharacterized protein [KO:K10740]
Dpse_GA17620  uncharacterized protein, isoform A [KO:K10848] [EC:3.1.-.-]
Dpse_GA10163  uncharacterized protein [KO:K10849]
Dpse_GA19253  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dpse_GA11341  uncharacterized protein [KO:K02328]
Dpse_GA17815  uncharacterized protein [KO:K03504]
Dpse_GA19850  uncharacterized protein [KO:K02324] [EC:2.7.7.7]
Dpse_GA10347  uncharacterized protein [KO:K02325] [EC:2.7.7.7]
Dpse_GA17216  uncharacterized protein [KO:K02326] [EC:2.7.7.7]
Dpse_GA10901  uncharacterized protein [KO:K03506] [EC:2.7.7.7]
Dpse_GA21602  uncharacterized protein [KO:K04802]
Dpse_GA10201  uncharacterized protein [KO:K04802]
Dpse_GA10826  uncharacterized protein [KO:K10754]
Dpse_GA20846  uncharacterized protein [KO:K10755]
Dpse_GA13416  uncharacterized protein [KO:K10755]
Dpse_GA19473  uncharacterized protein [KO:K10756]
Dpse_GA25212  uncharacterized protein [KO:K10756]
Dpse_GA18999  uncharacterized protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
dpo03020  RNA polymerase
dpo04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG GENES (42)   
All databases (43)   

Download RDF
DBGET integrated database retrieval system