KEGG   PATHWAY: dpo03440
Entry
dpo03440                    Pathway                                

Name
Homologous recombination - Drosophila pseudoobscura pseudoobscura
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
dpo03440  Homologous recombination
dpo03440

Other DBs
GO: 0000724
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA18119  uncharacterized protein [KO:K03111]
Dpse_GA19522  uncharacterized protein [KO:K10866] [EC:3.6.-.-]
Dpse_GA14221  uncharacterized protein [KO:K10865]
Dpse_GA19836  uncharacterized protein [KO:K10867]
Dpse_GA19668  uncharacterized protein [KO:K04728] [EC:2.7.11.1]
Dpse_GA10802  uncharacterized protein [KO:K10728]
Dpse_GA12520  uncharacterized protein [KO:K10881]
Dpse_GA21928  uncharacterized protein [KO:K07466]
Dpse_GA21663  uncharacterized protein [KO:K10739]
Dpse_GA13581  uncharacterized protein [KO:K10740]
Dpse_GA20711  uncharacterized protein [KO:K04482]
Dpse_GA15983  uncharacterized protein [KO:K10870]
Dpse_GA15366  uncharacterized protein [KO:K10871]
Dpse_GA17378  uncharacterized protein [KO:K10880]
Dpse_GA17651  uncharacterized protein [KO:K10875] [EC:3.6.4.-]
Dpse_GA19253  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dpse_GA11341  uncharacterized protein [KO:K02328]
Dpse_GA17815  uncharacterized protein [KO:K03504]
Dpse_GA19957  uncharacterized protein [KO:K10901] [EC:3.6.4.12]
Dpse_GA17464  uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dpse_GA10090  uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dpse_GA15732  uncharacterized protein [KO:K08991] [EC:3.1.22.-]
Dpse_GA11922  uncharacterized protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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