KEGG   PATHWAY: dpo03460
Entry
dpo03460                    Pathway                                

Name
Fanconi anemia pathway - Drosophila pseudoobscura pseudoobscura
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
dpo03460  Fanconi anemia pathway
dpo03460

Other DBs
GO: 0043240
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA26566  uncharacterized protein [KO:K06640] [EC:2.7.11.1]
Dpse_GA27149  uncharacterized protein, isoform B [KO:K10896]
Dpse_GA11825  uncharacterized protein [KO:K10606] [EC:2.3.2.27]
Dpse_GA21511  uncharacterized protein [KO:K15361]
Dpse_GA13968  uncharacterized protein, isoform A [KO:K11832] [EC:3.4.19.12]
Dpse_GA24859  uncharacterized protein [KO:K10895]
Dpse_GA26739  uncharacterized protein [KO:K10891]
Dpse_GA15983  uncharacterized protein [KO:K10870]
Dpse_GA20711  uncharacterized protein [KO:K04482]
Dpse_GA11026  uncharacterized protein [KO:K08734]
Dpse_GA20862  uncharacterized protein, isoform A [KO:K10858]
Dpse_GA11465  uncharacterized protein [KO:K03515] [EC:2.7.7.-]
Dpse_GA15135  uncharacterized protein, isoform A [KO:K02350] [EC:2.7.7.7]
Dpse_GA20133  uncharacterized protein [KO:K03509] [EC:2.7.7.7]
Dpse_GA20473  uncharacterized protein, isoform A [KO:K03510] [EC:2.7.7.7]
Dpse_GA17464  uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dpse_GA10090  uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dpse_GA19957  uncharacterized protein [KO:K10901] [EC:3.6.4.12]
Dpse_GA21928  uncharacterized protein [KO:K07466]
Dpse_GA21663  uncharacterized protein [KO:K10739]
Dpse_GA13581  uncharacterized protein [KO:K10740]
Dpse_GA15732  uncharacterized protein [KO:K08991] [EC:3.1.22.-]
Dpse_GA11922  uncharacterized protein [KO:K10882] [EC:3.1.22.-]
Dpse_GA17620  uncharacterized protein, isoform A [KO:K10848] [EC:3.1.-.-]
Dpse_GA10163  uncharacterized protein [KO:K10849]
Dpse_GA27368  uncharacterized protein [KO:K15078] [EC:3.6.1.-]
Reference
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
dpo03430  Mismatch repair
dpo03440  Homologous recombination
KO pathway
ko03460   

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