KEGG   PATHWAY: dpo04142
Entry
dpo04142                    Pathway                                

Name
Lysosome - Drosophila pseudoobscura pseudoobscura
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
dpo04142  Lysosome
dpo04142

Other DBs
GO: 0005764
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA20518  uncharacterized protein [KO:K02154]
Dpse_GA11714  uncharacterized protein [KO:K02154]
Dpse_GA15764  uncharacterized protein [KO:K02154]
Dpse_GA14320  uncharacterized protein, isoform H [KO:K02154]
Dpse_GA15015  uncharacterized protein [KO:K02154]
Dpse_GA15530  uncharacterized protein [KO:K02146]
Dpse_GA18311  uncharacterized protein [KO:K02146]
Dpse_GA14464  uncharacterized protein, isoform A [KO:K02144]
Dpse_GA20777  uncharacterized protein, isoform A [KO:K03662]
Dpse_GA16335  uncharacterized protein [KO:K02155]
Dpse_GA21477  uncharacterized protein [KO:K02155]
Dpse_GA26306  uncharacterized protein [KO:K02155]
Dpse_GA25245  uncharacterized protein, isoform A [KO:K02155]
Dpse_GA26304  uncharacterized protein, isoform A [KO:K02155]
Dpse_GA20025  uncharacterized protein, isoform A [KO:K03661]
Dpse_GA26375  uncharacterized protein [KO:K03661]
Dpse_GA10694  uncharacterized protein [KO:K01363] [EC:3.4.22.1]
Dpse_GA13759  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA25369  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA22213  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA17303  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA19187  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA16570  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA26724  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA10074  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA16571  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA14439  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA19184  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA16375  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA14340  uncharacterized protein [KO:K01379] [EC:3.4.23.5]
Dpse_GA22674  uncharacterized protein [KO:K01382] [EC:3.4.23.34]
Dpse_GA27408  uncharacterized protein, isoform A [KO:K01373] [EC:3.4.22.41]
Dpse_GA25021  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA23505  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA23577  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA24205  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA19520  uncharacterized protein [KO:K01365] [EC:3.4.22.15]
Dpse_GA20753  uncharacterized protein, isoform A [KO:K01189] [EC:3.2.1.22]
Dpse_GA26269  uncharacterized protein [KO:K01189] [EC:3.2.1.22]
Dpse_GA16177  uncharacterized protein, isoform A [KO:K12309] [EC:3.2.1.23]
Dpse_GA25341  uncharacterized protein, isoform A [KO:K12309] [EC:3.2.1.23]
Dpse_GA16046  uncharacterized protein [KO:K01201] [EC:3.2.1.45]
Dpse_GA26980  uncharacterized protein [KO:K01201] [EC:3.2.1.45]
Dpse_GA19435  uncharacterized protein [KO:K01217] [EC:3.2.1.76]
Dpse_GA27712  uncharacterized protein, isoform A [KO:K01204] [EC:3.2.1.49]
Dpse_GA12255  uncharacterized protein [KO:K01205] [EC:3.2.1.50]
Dpse_GA24063  uncharacterized protein [KO:K01195] [EC:3.2.1.31]
Dpse_GA13505  uncharacterized protein, isoform F [KO:K01195] [EC:3.2.1.31]
Dpse_GA23876  uncharacterized protein [KO:K01206] [EC:3.2.1.51]
Dpse_GA26101  uncharacterized protein [KO:K12373] [EC:3.2.1.52]
Dpse_GA14705  uncharacterized protein [KO:K12373] [EC:3.2.1.52]
Dpse_GA12099  uncharacterized protein [KO:K12373] [EC:3.2.1.52]
Dpse_GA11702  uncharacterized protein [KO:K01192] [EC:3.2.1.25]
Dpse_GA26271  uncharacterized protein [KO:K01192] [EC:3.2.1.25]
Dpse_GA28079  uncharacterized protein, isoform A [KO:K12311] [EC:3.2.1.24]
Dpse_GA28078  uncharacterized protein [KO:K12311] [EC:3.2.1.24]
Dpse_GA28080  uncharacterized protein [KO:K12311] [EC:3.2.1.24]
Dpse_GA27829  uncharacterized protein [KO:K12311] [EC:3.2.1.24]
Dpse_GA23896  uncharacterized protein, isoform A [KO:K01135] [EC:3.1.6.12]
Dpse_GA21235  uncharacterized protein, isoform B [KO:K01135] [EC:3.1.6.12]
Dpse_GA24970  uncharacterized protein [KO:K01137] [EC:3.1.6.14]
Dpse_GA11337  uncharacterized protein, isoform A [KO:K01136] [EC:3.1.6.13]
Dpse_GA12883  uncharacterized protein [KO:K01565] [EC:3.10.1.1]
Dpse_GA19361  uncharacterized protein, isoform A [KO:K01052] [EC:3.1.1.13]
Dpse_GA21347  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA10982  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA20819  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA25803  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA22417  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA11091  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA32614  uncharacterized protein [KO:K01052] [EC:3.1.1.13]
Dpse_GA15103  uncharacterized protein [KO:K06129] [EC:3.1.1.5]
Dpse_GA20583  uncharacterized protein [KO:K01158] [EC:3.1.22.1]
Dpse_GA19756  uncharacterized protein [KO:K14410] [EC:3.1.3.2]
Dpse_GA26867  uncharacterized protein, isoform A [KO:K14410] [EC:3.1.3.2]
Dpse_GA17413  uncharacterized protein, isoform A [KO:K12350] [EC:3.1.4.12]
Dpse_GA13792  uncharacterized protein [KO:K12350] [EC:3.1.4.12]
Dpse_GA13791  uncharacterized protein [KO:K12350] [EC:3.1.4.12]
Dpse_GA14866  uncharacterized protein [KO:K01444] [EC:3.5.1.26]
Dpse_GA18140  uncharacterized protein [KO:K01444] [EC:3.5.1.26]
Dpse_GA11373  uncharacterized protein [KO:K12382]
Dpse_GA11401  uncharacterized protein [KO:K01074] [EC:3.1.2.22]
Dpse_GA18478  uncharacterized protein [KO:K01074] [EC:3.1.2.22]
Dpse_GA17249  uncharacterized protein [KO:K06528]
Dpse_GA21246  uncharacterized protein, isoform A [KO:K06497]
Dpse_GA21830  uncharacterized protein, isoform A [KO:K06497]
Dpse_GA10076  uncharacterized protein [KO:K06497]
Dpse_GA11851  uncharacterized protein [KO:K06497]
Dpse_GA15095  uncharacterized protein, isoform A [KO:K06497]
Dpse_GA15688  uncharacterized protein [KO:K06497]
Dpse_GA21493  uncharacterized protein [KO:K06497]
Dpse_GA11852  uncharacterized protein [KO:K06497]
Dpse_GA11389  uncharacterized protein [KO:K12385]
Dpse_GA25612  uncharacterized protein [KO:K12385]
Dpse_GA20242  uncharacterized protein [KO:K13443]
Dpse_GA10910  uncharacterized protein [KO:K13443]
Dpse_GA16235  uncharacterized protein [KO:K13443]
Dpse_GA17784  uncharacterized protein [KO:K13443]
Dpse_GA16304  uncharacterized protein, isoform A [KO:K13443]
Dpse_GA11826  uncharacterized protein [KO:K13443]
Dpse_GA19402  uncharacterized protein, isoform A [KO:K13443]
Dpse_GA27047  uncharacterized protein [KO:K12386]
Dpse_GA22061  uncharacterized protein [KO:K12301]
Dpse_GA20823  uncharacterized protein, isoform A [KO:K12301]
Dpse_GA24909  uncharacterized protein [KO:K12301]
Dpse_GA21326  uncharacterized protein, isoform A [KO:K12301]
Dpse_GA27256  uncharacterized protein, isoform A [KO:K12301]
Dpse_GA24673  uncharacterized protein [KO:K12301]
Dpse_GA13487  uncharacterized protein, isoform B [KO:K12301]
Dpse_GA13486  uncharacterized protein [KO:K12301]
Dpse_GA17603  uncharacterized protein [KO:K21398]
Dpse_GA15783  uncharacterized protein, isoform B [KO:K12387]
Dpse_GA18985  uncharacterized protein, isoform A [KO:K12389]
Dpse_GA28324  uncharacterized protein, isoform A [KO:K12307]
Dpse_GA19944  uncharacterized protein [KO:K10532] [EC:2.3.1.78]
Dpse_GA28486  uncharacterized protein [KO:K13444] [EC:1.8.3.7]
Dpse_GA15985  uncharacterized protein, isoform B [KO:K06564]
Dpse_GA21476  uncharacterized protein [KO:K04646]
Dpse_GA26124  uncharacterized protein, isoform A [KO:K12391]
Dpse_GA11682  uncharacterized protein, isoform A [KO:K12392]
Dpse_GA21750  uncharacterized protein [KO:K12393]
Dpse_GA19188  uncharacterized protein, isoform A [KO:K12394]
Dpse_GA10688  uncharacterized protein, isoform A [KO:K12396]
Dpse_GA11000  uncharacterized protein [KO:K12397]
Dpse_GA15778  uncharacterized protein [KO:K12398]
Dpse_GA15753  uncharacterized protein [KO:K12399]
Dpse_GA15580  uncharacterized protein [KO:K12404]
Dpse_GA12335  uncharacterized protein [KO:K19363]
Dpse_GA12336  uncharacterized protein [KO:K19363]
Dpse_GA15738  uncharacterized protein [KO:K19363]
Dpse_GA15742  uncharacterized protein [KO:K19363]
Dpse_GA18059  uncharacterized protein [KO:K19363]
Dpse_GA24695  uncharacterized protein, isoform A [KO:K19363]
Dpse_GA24696  uncharacterized protein, isoform A [KO:K19363]
Dpse_GA24697  uncharacterized protein [KO:K19363]
Dpse_GA24699  uncharacterized protein [KO:K19363]
Dpse_GA16808  uncharacterized protein [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Related
pathway
dpo00511  Other glycan degradation
dpo00531  Glycosaminoglycan degradation
dpo04130  SNARE interactions in vesicular transport
dpo04140  Autophagy - animal
dpo04144  Endocytosis
KO pathway
ko04142   

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