KEGG   PATHWAY: dpo04310
Entry
dpo04310                    Pathway                                

Name
Wnt signaling pathway - Drosophila pseudoobscura pseudoobscura
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
dpo04310  Wnt signaling pathway
dpo04310

Other DBs
GO: 0016055
Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA19439  uncharacterized protein [KO:K00181] [EC:2.3.1.250]
Dpse_GA18504  Dpse_wg; wg [KO:K03209]
Dpse_GA19569  uncharacterized protein [KO:K00444]
Dpse_GA18561  uncharacterized protein [KO:K00445]
Dpse_GA24226  uncharacterized protein, isoform A [KO:K00572]
Dpse_GA21093  uncharacterized protein [KO:K00714]
Dpse_GA25881  uncharacterized protein, isoform A [KO:K01064]
Dpse_GA18562  uncharacterized protein [KO:K01357]
Dpse_GA28563  uncharacterized protein, isoform A [KO:K19882] [EC:3.1.1.98]
Dpse_GA16199  uncharacterized protein, isoform A [KO:K01691]
Dpse_GA18565  uncharacterized protein [KO:K02306]
Dpse_GA21416  uncharacterized protein, isoform A [KO:K08399]
Dpse_GA14615  uncharacterized protein [KO:K02432]
Dpse_GA18313  uncharacterized protein [KO:K02354]
Dpse_GA28694  uncharacterized protein [KO:K02354]
Dpse_GA23719  uncharacterized protein [KO:K02354]
Dpse_GA21999  uncharacterized protein [KO:K02375]
Dpse_GA14147  uncharacterized protein [KO:K04690]
Dpse_GA19223  uncharacterized protein, isoform A [KO:K03068]
Dpse_GA15205  uncharacterized protein, isoform D [KO:K08960] [EC:2.7.11.1]
Dpse_GA14904  uncharacterized protein [KO:K02353]
Dpse_GA22219  uncharacterized protein [KO:K03097] [EC:2.7.11.1]
Dpse_GA21406  uncharacterized protein [KO:K03115]
Dpse_GA25112  uncharacterized protein [KO:K03115]
Dpse_GA27055  uncharacterized protein [KO:K03115]
Dpse_GA22384  uncharacterized protein [KO:K03115]
Dpse_GA11099  uncharacterized protein [KO:K03213]
Dpse_GA22660  uncharacterized protein, isoform H [KO:K03083] [EC:2.7.11.26]
Dpse_GA15928  uncharacterized protein [KO:K03083] [EC:2.7.11.26]
Dpse_GA18716  uncharacterized protein [KO:K03083] [EC:2.7.11.26]
Dpse_GA27602  uncharacterized protein, isoform A [KO:K02105]
Dpse_GA20694  uncharacterized protein, isoform A [KO:K02157]
Dpse_GA13041  uncharacterized protein, isoform A [KO:K02085]
Dpse_GA19428  uncharacterized protein [KO:K02085]
Dpse_GA20096  uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dpse_GA27399  uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dpse_GA26095  uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dpse_GA15396  uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dpse_GA15193  uncharacterized protein, isoform A [KO:K08957] [EC:2.7.11.1]
Dpse_GA31358  uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dpse_GA14746  uncharacterized protein, isoform A [KO:K04491]
Dpse_GA12268  uncharacterized protein [KO:K23402]
Dpse_GA20456  uncharacterized protein, isoform F [KO:K04496]
Dpse_GA21035  uncharacterized protein, isoform A [KO:K04497]
Dpse_GA30789  uncharacterized protein [KO:K23491]
Dpse_GA13644  uncharacterized protein [KO:K04498] [EC:2.3.1.48]
Dpse_GA17841  uncharacterized protein [KO:K04499] [EC:3.6.4.12]
Dpse_GA14643  uncharacterized protein, isoform C [KO:K04501]
Dpse_GA15332  uncharacterized protein [KO:K23605]
Dpse_GA18443  uncharacterized protein [KO:K04427] [EC:2.7.11.25]
Dpse_GA16242  uncharacterized protein [KO:K04427] [EC:2.7.11.25]
Dpse_GA14958  uncharacterized protein [KO:K04427] [EC:2.7.11.25]
Dpse_GA28383  uncharacterized protein [KO:K04468] [EC:2.7.11.24]
Dpse_GA10565  uncharacterized protein [KO:K04377]
Dpse_GA30492  uncharacterized protein [KO:K04448]
Dpse_GA27869  uncharacterized protein, isoform A [KO:K10151]
Dpse_GA15086  uncharacterized protein, isoform A [KO:K04505] [EC:3.4.23.-]
Dpse_GA11370  uncharacterized protein, isoform A [KO:K04345] [EC:2.7.11.11]
Dpse_GA18145  uncharacterized protein, isoform C [KO:K04345] [EC:2.7.11.11]
Dpse_GA11372  uncharacterized protein [KO:K04345] [EC:2.7.11.11]
Dpse_GA22147  uncharacterized protein, isoform B [KO:K04506] [EC:2.3.2.27]
Dpse_GA11985  uncharacterized protein [KO:K04506] [EC:2.3.2.27]
Dpse_GA16794  uncharacterized protein [KO:K04507]
Dpse_GA14255  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA21386  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA22610  uncharacterized protein [KO:K03094]
Dpse_GA22210  uncharacterized protein [KO:K03094]
Dpse_GA23292  uncharacterized protein [KO:K03094]
Dpse_GA24828  uncharacterized protein [KO:K03094]
Dpse_GA25479  uncharacterized protein [KO:K03094]
Dpse_GA25480  uncharacterized protein [KO:K03094]
Dpse_GA25902  uncharacterized protein [KO:K03094]
Dpse_GA26756  uncharacterized protein [KO:K03094]
Dpse_GA26757  uncharacterized protein [KO:K03094]
Dpse_GA28458  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA28459  uncharacterized protein [KO:K03094]
Dpse_GA28460  uncharacterized protein [KO:K03094]
Dpse_GA28461  uncharacterized protein [KO:K03094]
Dpse_GA28645  uncharacterized protein [KO:K03094]
Dpse_GA32779  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA30691  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA32998  uncharacterized protein, isoform A [KO:K03094]
Dpse_GA31969  uncharacterized protein [KO:K03094]
Dpse_GA17928  uncharacterized protein [KO:K04508]
Dpse_GA30839  uncharacterized protein [KO:K04508]
Dpse_GA27349  uncharacterized protein [KO:K03362]
Dpse_GA15074  uncharacterized protein [KO:K03347]
Dpse_GA10874  uncharacterized protein [KO:K03347]
Dpse_GA14260  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA22841  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA23017  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA24410  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dpse_GA16712  uncharacterized protein [KO:K08110]
Dpse_GA14553  uncharacterized protein [KO:K05128] [EC:2.7.10.1]
Dpse_GA14473  uncharacterized protein [KO:K05128] [EC:2.7.10.1]
Dpse_GA24416  uncharacterized protein, isoform D [KO:K05128] [EC:2.7.10.1]
Dpse_GA24846  uncharacterized protein [KO:K04510]
Dpse_GA10748  uncharacterized protein, isoform B [KO:K04511]
Dpse_GA11840  uncharacterized protein [KO:K04511]
Dpse_GA13122  uncharacterized protein [KO:K04512]
Dpse_GA25121  uncharacterized protein, isoform A [KO:K04513]
Dpse_GA15321  uncharacterized protein [KO:K04392]
Dpse_GA18989  uncharacterized protein [KO:K04392]
Dpse_GA21734  uncharacterized protein, isoform A [KO:K04392]
Dpse_GA23612  uncharacterized protein [KO:K04392]
Dpse_GA17564  uncharacterized protein, isoform A [KO:K05858] [EC:3.1.4.11]
Dpse_GA18269  uncharacterized protein [KO:K05858] [EC:3.1.4.11]
Dpse_GA22069  uncharacterized protein [KO:K04348] [EC:3.1.3.16]
Dpse_GA22549  uncharacterized protein [KO:K04348] [EC:3.1.3.16]
Dpse_GA26888  uncharacterized protein, isoform A [KO:K04348] [EC:3.1.3.16]
Dpse_GA18033  uncharacterized protein, isoform D [KO:K06268]
Dpse_GA24505  uncharacterized protein [KO:K06268]
Dpse_GA32082  uncharacterized protein [KO:K06268]
Dpse_GA19732  uncharacterized protein, isoform A [KO:K02677] [EC:2.7.11.13]
Dpse_GA19657  uncharacterized protein [KO:K19662] [EC:2.7.11.13]
Compound
C00076  Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Related
pathway
dpo04120  Ubiquitin mediated proteolysis
dpo04350  TGF-beta signaling pathway
KO pathway
ko04310   

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