KEGG   PATHWAY: dse03015
Entry
dse03015                    Pathway                                
Name
mRNA surveillance pathway - Drosophila sechellia
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
dse03015  mRNA surveillance pathway
dse03015

Other DBs
GO: 0071028
Organism
Drosophila sechellia [GN:dse]
Gene
6612480  nuclear cap-binding protein subunit 1 [KO:K12882]
6614347  nuclear cap-binding protein subunit 1 [KO:K12882]
6616657  nuclear cap-binding protein subunit 2 [KO:K12883]
6608298  RNA-binding protein 8A [KO:K12876]
6615307  protein mago nashi [KO:K12877]
6618706  protein CASC3 [KO:K14323]
6607281  eukaryotic initiation factor 4A-III [KO:K13025] [EC:3.6.4.13]
6606153  histone deacetylase complex subunit SAP18 [KO:K14324]
6607055  pinin isoform X1 [KO:K13114]
6614635  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
6607096  RNA-binding protein with serine-rich domain 1-A [KO:K14325]
6614192  THO complex subunit 4 isoform X1 [KO:K12881]
6617755  THO complex subunit 4 [KO:K12881]
116800892  DEAD-box helicase Dbp80 isoform X1 [KO:K18655] [EC:3.6.4.13]
6608208  nucleoporin Gle1 [KO:K18723]
6617590  nuclear RNA export factor 1 [KO:K14284]
6615774  NTF2-related export protein [KO:K14285]
6613492  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:3.6.4.13]
116800317  partner of Y14 and mago [KO:K14294]
6605530  serine/arginine repetitive matrix protein 1 [KO:K13171]
6618519  mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
6617908  RNA-binding protein cabeza isoform X1 [KO:K13098]
6615786  TAR DNA-binding protein 43 [KO:K23600]
6605769  TAR DNA-binding protein 43 [KO:K23600]
6608123  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
6604856  cleavage and polyadenylation specificity factor subunit CG7185 isoform X1 [KO:K14398]
6609009  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
6609220  uncharacterized protein LOC6609220 isoform X2 [KO:K14400]
6609153  cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
6613738  cleavage and polyadenylation specificity factor 73 [KO:K14403] [EC:3.1.27.-]
116800360  cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
6613835  pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
6614007  pre-mRNA 3' end processing protein WDR33 [KO:K15542]
6611670  WD repeat-containing protein 82 [KO:K14962]
116803406  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
6615468  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
6617550  serine/threonine-protein phosphatase beta isoform isoform X1 [KO:K06269] [EC:3.1.3.16]
6606667  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
6620369  serine/threonine-protein phosphatase alpha-3 isoform [KO:K06269] [EC:3.1.3.16]
6609714  serine/threonine-protein phosphatase PP-Y [KO:K06269] [EC:3.1.3.16]
6615035  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
6619515  cleavage stimulation factor subunit 1 [KO:K14406]
6613739  cleavage stimulation factor subunit 2 [KO:K14407]
6614019  symplekin [KO:K06100]
6616936  poly(U)-binding-splicing factor half pint isoform X1 [KO:K14411]
6617094  ribonucleoprotein RB97D isoform X1 [KO:K14411]
6606055  RNA-binding protein Musashi homolog Rbp6 isoform X3 [KO:K14411]
6606504  ribonucleoprotein RB97D isoform X1 [KO:K14411]
6609737  polyadenylate-binding protein [KO:K13126]
6616281  eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
6617741  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
6612198  serine/threonine-protein kinase Smg1 isoform X1 [KO:K08873] [EC:2.7.11.1]
6611218  protein SMG5 [KO:K11125]
6619632  telomerase-binding protein EST1A [KO:K11124] [EC:3.1.-.-]
6611581  serine/threonine-protein phosphatase PP2A isoform X1 [KO:K04382] [EC:3.1.3.16]
6611668  serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit isoform X2 [KO:K03456]
6606984  protein phosphatase PP2A 55 kDa regulatory subunit isoform X1 [KO:K04354]
6619025  uncharacterized protein LOC6619025 [KO:K11583]
6620790  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2 [KO:K11584]
6618683  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
6610416  HBS1-like protein [KO:K14416]
6611841  protein pelota [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
dse03013  Nucleocytoplasmic transport
dse03018  RNA degradation
dse03040  Spliceosome
KO pathway
ko03015   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG GENES (62)   
All databases (63)   

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