KEGG   PATHWAY: dsi03440Help
Entry
dsi03440                    Pathway                                

Name
Homologous recombination - Drosophila simulans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
dsi03440  Homologous recombination
dsi03440

Ortholog table
Module
dsi_M00288  RPA complex [PATH:dsi03440]
dsi_M00291  MRN complex [PATH:dsi03440]
dsi_M00295  BRCA1-associated genome surveillance complex (BASC) [PATH:dsi03440]
Other DBs
BSID: 121583
GO: 0000724
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD20303  Dsim_GD20303; GD20303 gene product from transcript GD20303-RA [KO:K03111]
Dsimw501_GD11670  Dsim_GD11670; GD11670 gene product from transcript GD11670-RB [KO:K10866] [EC:3.6.-.-]
Dsimw501_GD23775  Dsim_GD23775; GD23775 gene product from transcript GD23775-RA [KO:K10865]
Dsimw501_GD12898  Dsim_GD12898; GD12898 gene product from transcript GD12898-RB [KO:K10867]
Dsimw501_GD20371  Dsim_GD20371; GD20371 gene product from transcript GD20371-RB [KO:K04728] [EC:2.7.11.1]
Dsimw501_GD28991  Dsim_GD28991; GD28991 gene product from transcript GD28991-RA [KO:K10728]
Dsimw501_GD29456  Dsim_GD29456; GD29456 gene product from transcript GD29456-RA [KO:K10881]
Dsimw501_GD20882  Dsim_GD20882; GD20882 gene product from transcript GD20882-RA [KO:K07466]
Dsimw501_GD20884  Dsim_GD20884; GD20884 gene product from transcript GD20884-RB [KO:K07466]
Dsimw501_GD21666  Dsim_GD21666; GD21666 gene product from transcript GD21666-RA [KO:K10739]
Dsimw501_GD15982  Dsim_GD15982; GD15982 gene product from transcript GD15982-RA [KO:K10740]
Dsimw501_GD17366  Dsim_GD17366; GD17366 gene product from transcript GD17366-RA [KO:K04482]
Dsimw501_GD21329  Dsim_GD21329; GD21329 gene product from transcript GD21329-RC [KO:K10870]
Dsimw501_GD10641  Dsim_GD10641; GD10641 gene product from transcript GD10641-RA [KO:K10871]
Dsimw501_GD18959  Dsim_GD18959; GD18959 gene product from transcript GD18959-RA [KO:K10880]
Dsimw501_GD12001  Dsim_GD12001; GD12001 gene product from transcript GD12001-RA [KO:K10875] [EC:3.6.4.-]
Dsimw501_GD12524  Dsim_GD12524; GD12524 gene product from transcript GD12524-RA [KO:K02327] [EC:2.7.7.7]
Dsimw501_GD13645  Dsim_GD13645; GD13645 gene product from transcript GD13645-RA [KO:K02328]
Dsimw501_GD21967  Dsim_GD21967; GD21967 gene product from transcript GD21967-RA [KO:K03504]
Dsimw501_GD20640  Dsim_GD20640; GD20640 gene product from transcript GD20640-RB [KO:K10901] [EC:3.6.4.12]
Dsimw501_GD16199  Dsim_GD16199; GD16199 gene product from transcript GD16199-RB [KO:K03165] [EC:5.99.1.2]
Dsimw501_GD24215  Dsim_GD24215; GD24215 gene product from transcript GD24215-RB [KO:K03165] [EC:5.99.1.2]
Dsimw501_GD16537  Dsim_GD16537; GD16537 gene product from transcript GD16537-RA [KO:K08991] [EC:3.1.22.-]
Dsimw501_GD10756  Dsim_GD10756; GD10756 gene product from transcript GD10756-RA [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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