KEGG   PATHWAY: dsi03440
Entry
dsi03440                    Pathway                                
Name
Homologous recombination - Drosophila simulans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
dsi03440  Homologous recombination
dsi03440

Other DBs
GO: 0000724
Organism
Drosophila simulans [GN:dsi]
Gene
Dsimw501_GD10641  Dsim_GD10641; uncharacterized protein [KO:K10871]
Dsimw501_GD10756  Dsim_GD10756; uncharacterized protein [KO:K10882] [EC:3.1.22.-]
Dsimw501_GD11670  Dsim_GD11670; uncharacterized protein [KO:K10866] [EC:3.6.-.-]
Dsimw501_GD12001  Dsim_GD12001; uncharacterized protein [KO:K10875] [EC:5.6.2.-]
Dsimw501_GD12524  Dsim_GD12524; uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dsimw501_GD12898  Dsim_GD12898; uncharacterized protein, isoform B [KO:K10867]
Dsimw501_GD13645  Dsim_GD13645; uncharacterized protein [KO:K02328]
Dsimw501_GD15982  Dsim_GD15982; uncharacterized protein [KO:K10740]
Dsimw501_GD16199  Dsim_GD16199; uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dsimw501_GD16537  Dsim_GD16537; uncharacterized protein [KO:K08991] [EC:3.1.22.-]
Dsimw501_GD17366  Dsim_GD17366; uncharacterized protein [KO:K04482]
Dsimw501_GD18959  Dsim_GD18959; uncharacterized protein [KO:K10880]
Dsimw501_GD20303  Dsim_GD20303; uncharacterized protein [KO:K03111]
Dsimw501_GD20371  Dsim_GD20371; uncharacterized protein [KO:K04728] [EC:2.7.11.1]
Dsimw501_GD20640  Dsim_GD20640; uncharacterized protein [KO:K10901] [EC:5.6.2.4]
Dsimw501_GD20882  Dsim_GD20882; uncharacterized protein [KO:K07466]
Dsimw501_GD21329  Dsim_GD21329; uncharacterized protein, isoform B [KO:K10870]
Dsimw501_GD21666  Dsim_GD21666; uncharacterized protein [KO:K10739]
Dsimw501_GD21967  Dsim_GD21967; uncharacterized protein [KO:K03504]
Dsimw501_GD23775  Dsim_GD23775; uncharacterized protein [KO:K10865]
Dsimw501_GD24215  Dsim_GD24215; uncharacterized protein [KO:K03165] [EC:5.6.2.1]
Dsimw501_GD28991  Dsim_GD28991; uncharacterized protein [KO:K10728]
Dsimw501_GD29456  Dsim_GD29456; uncharacterized protein [KO:K10881]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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