KEGG   PATHWAY: ebw00564Help
Entry
ebw00564                    Pathway                                

Name
Glycerophospholipid metabolism - Escherichia coli BW2952
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ebw00564  Glycerophospholipid metabolism
ebw00564

Ortholog table
Module
ebw_M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ebw00564]
Other DBs
BSID: 98702
GO: 0006650 0046474 0046475
Organism
Escherichia coli BW2952 [GN:ebw]
Gene
BWG_3299  gpsA; glycerol-3-phosphate dehydrogenase (NAD+) [KO:K00057] [EC:1.1.1.94]
BWG_2013  glpA; sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding [KO:K00111] [EC:1.1.5.3]
BWG_3119  glpD; sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding [KO:K00111] [EC:1.1.5.3]
BWG_2014  glpB; sn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit [KO:K00112] [EC:1.1.5.3]
BWG_2015  glpC; sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit [KO:K00113] [EC:1.1.5.3]
BWG_3754  plsB; glycerol-3-phosphate O-acyltransferase [KO:K00631] [EC:2.3.1.15]
BWG_0938  plsX; fatty acid/phospholipid synthesis protein [KO:K03621] [EC:2.3.1.15]
BWG_2770  ygiH; conserved inner membrane protein [KO:K08591] [EC:2.3.1.15]
BWG_2731  plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [KO:K00655] [EC:2.3.1.51]
BWG_3755  dgkA; diacylglycerol kinase [KO:K00901] [EC:2.7.1.107]
BWG_3499  pldA; outer membrane phospholipase A [KO:K01058] [EC:3.1.1.4 3.1.1.32]
BWG_3503  pldB; lysophospholipase L(2) [KO:K01048] [EC:3.1.1.5]
BWG_2011  glpQ; periplasmic glycerophosphodiester phosphodiesterase [KO:K01126] [EC:3.1.4.46]
BWG_3140  ugpQ; glycerophosphodiester phosphodiesterase, cytosolic [KO:K01126] [EC:3.1.4.46]
BWG_2572  aas; fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase [KO:K05939] [EC:6.2.1.20 2.3.1.40]
BWG_2213  eutA; reactivating factor for ethanolamine ammonia lyase [KO:K04019]
BWG_2203  eutB; ethanolamine ammonia-lyase, large subunit, heavy chain [KO:K03735] [EC:4.3.1.7]
BWG_2202  eutC; ethanolamine ammonia-lyase, small subunit (light chain) [KO:K03736] [EC:4.3.1.7]
BWG_3587  cdh; CDP-diacylglycerol phosphotidylhydrolase [KO:K01521] [EC:3.6.1.26]
BWG_1236  ynbB; predicted CDP-diglyceride synthase [KO:K00981] [EC:2.7.7.41]
BWG_0167  cdsA; CDP-diglyceride synthase [KO:K00981] [EC:2.7.7.41]
BWG_2349  pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998] [EC:2.7.8.8]
BWG_3875  psd; phosphatidylserine decarboxylase [KO:K01613] [EC:4.1.1.65]
BWG_1721  pgsA; phosphatidylglycerophosphate synthetase [KO:K00995] [EC:2.7.8.5]
BWG_0300  pgpA; phosphatidylglycerophosphatase A [KO:K01095] [EC:3.1.3.27]
BWG_1109  pgpB; phosphatidylglycerophosphatase B [KO:K01096] [EC:3.6.1.27 3.1.3.4 3.1.3.81 3.1.3.27]
BWG_2324  yfhB; conserved protein [KO:K18697] [EC:3.1.3.27]
BWG_1077  cls; cardiolipin synthase 1 [KO:K06131] [EC:2.7.8.-]
BWG_0642  ybhO; cardiolipin synthase 2 [KO:K06131] [EC:2.7.8.-]
BWG_0895  ymdC; predicted hydrolase [KO:K06132] [EC:2.7.8.-]
Compound
C00040  Acyl-CoA
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
KO pathway
ko00564   

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