KEGG   PATHWAY: ecc03440
Entry
ecc03440                    Pathway                                
Name
Homologous recombination - Escherichia coli O6:K2:H1 CFT073 (UPEC)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ecc03440  Homologous recombination
ecc03440

Other DBs
GO: 0000724
Organism
Escherichia coli O6:K2:H1 CFT073 (UPEC) [GN:ecc]
Gene
c3472  recJ; Single-stranded-DNA-specific exonuclease recJ [KO:K07462] [EC:3.1.-.-]
c5049  ssb; Single-strand binding protein [KO:K03111]
c4622  recF; DNA replication and repair protein recF [KO:K03629]
c3089  recO; DNA repair protein recO [KO:K03584]
c0592  recR; Recombination protein recR [KO:K06187]
c3253  recA; RecA protein [KO:K03553]
c2275  ruvA; Holliday junction DNA helicase ruvA [KO:K03550]
c2274  ruvB; Holliday junction DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
c2277  ruvC; Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.21.10]
c4477  recG; ATP-dependent DNA helicase recG [KO:K03655] [EC:5.6.2.4]
c3414  recB; Exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
c3416  recC; Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
c3413  recD; Exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
c0221  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
c4623  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
c0589  dnaX; DNA polymerase III subunit tau [KO:K02343] [EC:2.7.7.7]
c0731  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
c1371  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
c0252  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
c1213  Hypothetical protein [KO:K02342] [EC:2.7.7.7]
c2252  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
c5359  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
c5452  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
c4888  priA; Primosomal protein N' [KO:K04066] [EC:5.6.2.4]
c0586  priC; Primosomal replication protein N [KO:K04067]
c5441  dnaT; Primosomal protein I [KO:K02317]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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