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Entry
etc02010                    Pathway                                

Name
ABC transporters - Edwardsiella piscicida C07-087
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
etc02010  ABC transporters
etc02010

Ortholog table
Module
etc_M00189  Molybdate transport system [PATH:etc02010]
etc_M00190  Iron(III) transport system [PATH:etc02010]
etc_M00191  Thiamine transport system [PATH:etc02010]
etc_M00194  Maltose/maltodextrin transport system [PATH:etc02010]
etc_M00198  Putative sn-glycerol-phosphate transport system [PATH:etc02010]
etc_M00210  Phospholipid transport system [PATH:etc02010]
etc_M00212  Ribose transport system [PATH:etc02010]
etc_M00222  Phosphate transport system [PATH:etc02010]
etc_M00227  Glutamine transport system [PATH:etc02010]
etc_M00229  Arginine transport system [PATH:etc02010]
etc_M00230  Glutamate/aspartate transport system [PATH:etc02010]
etc_M00234  L-Cystine transport system [PATH:etc02010]
etc_M00238  D-Methionine transport system [PATH:etc02010]
etc_M00239  Peptides/nickel transport system [PATH:etc02010]
etc_M00240  Iron complex transport system [PATH:etc02010]
etc_M00241  Vitamin B12 transport system [PATH:etc02010]
etc_M00242  Zinc transport system [PATH:etc02010]
etc_M00245  Cobalt/nickel transport system [PATH:etc02010]
etc_M00246  Nickel transport system [PATH:etc02010]
etc_M00255  Lipoprotein-releasing system [PATH:etc02010]
etc_M00256  Cell division transport system [PATH:etc02010]
etc_M00259  Heme transport system [PATH:etc02010]
etc_M00299  Spermidine/putrescine transport system [PATH:etc02010]
etc_M00320  Lipopolysaccharide export system [PATH:etc02010]
etc_M00324  Dipeptide transport system [PATH:etc02010]
etc_M00439  Oligopeptide transport system [PATH:etc02010]
etc_M00440  Nickel transport system [PATH:etc02010]
etc_M00592  Inositol transport system [PATH:etc02010]
etc_M00739  Cationic peptide transport system [PATH:etc02010]
Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Edwardsiella piscicida C07-087 [GN:etc]
Gene
ETAC_04410  molybdenum ABC transporter substrate-binding protein [KO:K02020]
ETAC_12290  modA; molybdate transporter periplasmic protein [KO:K02020]
ETAC_04415  protein NifC [KO:K02018]
ETAC_12285  Molybdenum transport system permease ModB [KO:K02018]
ETAC_12280  modC; molybdate transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
ETAC_04420  ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
ETAC_06280  Ferric iron ABC transporter, iron-binding protein [KO:K02012]
ETAC_13335  Ferric iron ABC transporter, iron-binding protein [KO:K02012]
ETAC_06275  Ferric iron ABC transporter, permease protein [KO:K02011]
ETAC_13340  Ferric iron ABC transporter, permease protein [KO:K02011]
ETAC_06270  fbpC; ferric transporter ATP-binding subunit [KO:K02010] [EC:7.2.2.7]
ETAC_13345  Ferric iron ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
ETAC_02950  thiamin ABC transporter substrate-binding protein [KO:K02064]
ETAC_02945  thiP; thiamine transporter membrane protein [KO:K02063]
ETAC_02940  thiQ; thiamine transporter ATP-binding subunit [KO:K02062]
ETAC_08625  potD; spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069]
ETAC_08615  potC; spermidine/putrescine ABC transporter membrane protein [KO:K11070]
ETAC_08610  potB; spermidine/putrescine ABC transporter membrane protein [KO:K11071]
ETAC_08605  potA; putrescine/spermidine ABC transporter ATPase protein [KO:K11072] [EC:7.6.2.11]
ETAC_00880  malE; maltose ABC transporter periplasmic protein [KO:K10108]
ETAC_00875  malF; maltose transporter membrane protein [KO:K10109]
ETAC_00870  malG; maltose transporter permease [KO:K10110]
ETAC_00885  maltose/maltodextrin transporter ATP-binding protein [KO:K10111] [EC:3.6.3.-]
ETAC_02460  ABC transporter periplasmic binding protein MlaC [KO:K07323]
ETAC_02455  ABC transporter, periplasmic component YrbD [KO:K02067]
ETAC_02450  hypothetical protein [KO:K02066]
ETAC_02465  anti-sigma-factor antagonist [KO:K07122]
ETAC_02445  ABC transporter ATP-binding protein YrbF [KO:K02065]
ETAC_16885  D-ribose transporter subunit RbsB [KO:K10439]
ETAC_16890  rbsC; ribose ABC transporter permease protein [KO:K10440]
ETAC_16895  D-ribose transporter ATP binding protein [KO:K10441] [EC:3.6.3.17]
ETAC_16900  D-ribose pyranase, putative [KO:K06726] [EC:5.4.99.62]
ETAC_07585  periplasmic binding protein/LacI transcriptional regulator family [KO:K17208]
ETAC_07595  amino acid or sugar ABC transport systems, permease protein [KO:K17209]
ETAC_07590  ABC transporter, ATP-binding protein [KO:K17210]
ETAC_04330  extracellular solute-binding protein [KO:K05813]
ETAC_15845  glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813]
ETAC_04325  inner membrane component of binding-protein-dependent transport system [KO:K05814]
ETAC_15840  glycerol-3-phosphate transporter permease [KO:K05814]
ETAC_04320  binding-protein-dependent transport system inner membrane protein [KO:K05815]
ETAC_15835  glycerol-3-phosphate transporter membrane protein [KO:K05815]
ETAC_04335  sugar ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
ETAC_15830  ugpC; glycerol-3-phosphate transporter ATP-binding subunit [KO:K05816] [EC:7.6.2.10]
ETAC_17005  phosphate ABC transporter periplasmic substrate-binding protein PstS [KO:K02040]
ETAC_17010  pstC; phosphate transporter permease subunit PstC [KO:K02037]
ETAC_17015  pstA; phosphate transporter permease subunit PtsA [KO:K02038]
ETAC_17020  pstB; phosphate transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
ETAC_10885  glnH; glutamine ABC transporter periplasmic protein [KO:K10036]
ETAC_10890  glnP; glutamine ABC transporter permease protein [KO:K10037]
ETAC_10895  glnQ; glutamine ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
ETAC_10605  arginine ABC transporter periplasmic arginine-binding protein ArtJ [KO:K09996]
ETAC_10590  Arginine ABC transporter, periplasmic arginine-binding protein ArtI [KO:K09997]
ETAC_10600  artM; arginine transporter permease subunit ArtM [KO:K09998]
ETAC_10595  arginine transporter permease subunit ArtQ [KO:K09999]
ETAC_10585  Arginine ABC transporter, ATP-binding protein ArtP [KO:K10000] [EC:7.4.2.1]
ETAC_12645  Glutamate Aspartate periplasmic binding protein precursor GltI [KO:K10001]
ETAC_12655  glutamate/aspartate transport system permease GltK [KO:K10002]
ETAC_12650  glutamate/aspartate ABC transporter permease GltJ [KO:K10003]
ETAC_12660  Glutamate Aspartate transport ATP-binding protein GltL [KO:K10004] [EC:7.4.2.1]
ETAC_07225  amino acid ABC transporter substrate-binding protein [KO:K02424]
ETAC_07220  amino acid ABC transporter permease [KO:K10009]
ETAC_10090  Cystine ABC transporter, ATP-binding protein [KO:K10010] [EC:7.4.2.1]
ETAC_02675  methionine ABC transporter substrate-binding protein [KO:K02073]
ETAC_02680  DL-methionine transporter permease subunit [KO:K02072]
ETAC_02685  methionine ABC transporter ATP-binding protein [KO:K02071]
ETAC_07090  oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580]
ETAC_01140  hypothetical protein [KO:K15580]
ETAC_08495  murein tripeptide ABC transporter periplasmic substrate-binding protein [KO:K15580]
ETAC_07095  oppB; oligopeptide transporter permease [KO:K15581]
ETAC_07100  oligopeptide ABC transporter permease OppC [KO:K15582]
ETAC_07105  oppD; oligopeptide transporter ATP-binding component [KO:K15583]
ETAC_07110  oligopeptide ABC transporter ATP-binding protein OppF [KO:K10823]
ETAC_16190  dipeptide ABC transporter periplasmic substrate-binding protein DppA [KO:K12368]
ETAC_16185  dipeptide transporter permease DppB [KO:K12369]
ETAC_16180  dipeptide transporter [KO:K12370]
ETAC_16175  dppD; dipeptide transporter ATP-binding subunit [KO:K12371]
ETAC_16170  dppF; dipeptide transporter ATP-binding subunit [KO:K12372]
ETAC_08550  antimicrobial peptide ABC transporter periplasmic binding protein SapA [KO:K19226]
ETAC_08555  antimicrobial peptide ABC transporter permease SapB [KO:K19227]
ETAC_08560  antimicrobial peptide ABC transporter permease SapC [KO:K19228]
ETAC_08565  antimicrobial peptide ABC transporter ATP-binding protein [KO:K19229]
ETAC_08570  antimicrobial peptide ABC system ATP-binding protein SapF [KO:K19230]
ETAC_06520  Nickel ABC transporter, periplasmic nickel-binding protein NikA [KO:K15584]
ETAC_06515  nickel transporter permease NikB [KO:K15585]
ETAC_06510  nikC; nickel transporter permease NikC [KO:K15586]
ETAC_06505  nikD; nickel transporter ATP-binding protein NikD [KO:K15587] [EC:7.2.2.11]
ETAC_06500  nikE; nickel transporter ATP-binding protein NikE [KO:K10824] [EC:7.2.2.11]
ETAC_10905  Putative substrate-binding transport protein [KO:K13893]
ETAC_02975  ferrichrome-binding periplasmic protein [KO:K23227]
ETAC_02970  Ferrichrome transport ATP-binding protein FhuC [KO:K10829] [EC:7.2.2.16]
ETAC_13365  Vitamin B12 ABC transporter, B12-binding component BtuF [KO:K06858]
ETAC_08300  vtamin B12-transporter permease [KO:K06073]
ETAC_08295  Vitamin B12 ABC transporter, ATPase component BtuD [KO:K06074] [EC:7.6.2.8]
ETAC_06780  znuA; high-affinity zinc transporter periplasmic component [KO:K09815]
ETAC_06770  znuB; high-affinity zinc transporter membrane component [KO:K09816]
ETAC_06775  Zinc ABC transporter ATP-binding protein ZnuC [KO:K09817] [EC:7.2.2.-]
ETAC_09105  cobalt transport protein CbiN [KO:K02009]
ETAC_09110  cobalt transport protein CbiM [KO:K02007]
ETAC_09100  cobalt transport protein CbiQ [KO:K02008]
ETAC_09095  cbiO; cobalt transporter ATP-binding subunit [KO:K02006]
ETAC_09810  outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808]
ETAC_09820  outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808]
ETAC_09815  Lipoprotein releasing system ATP-binding protein LolD [KO:K09810] [EC:3.6.3.-]
ETAC_11640  Cytochrome c-type biogenesis protein CcmD [KO:K02196]
ETAC_11645  heme exporter protein CcmC, putative [KO:K02195]
ETAC_11650  ABC transporter involved in cytochrome c biogenesis, CcmB subunit [KO:K02194]
ETAC_11655  ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA [KO:K02193] [EC:7.6.2.5]
ETAC_14765  lipopolysaccharide ABC transporter permease LptF [KO:K07091]
ETAC_14760  lipopolysaccharide ABC transporter permease [KO:K11720]
ETAC_02415  lipopolysaccharide ABC transporter ATP-binding protein [KO:K06861] [EC:3.6.3.-]
ETAC_15875  ftsX; cell division ABC transporter subunit FtsX [KO:K09811]
ETAC_15880  cell division transporter ATP-binding protein FtsE [KO:K09812]
ETAC_10305  lipid transporter ATP-binding/permease protein [KO:K11085] [EC:3.6.3.-]
ETAC_02965  hypothetical protein [KO:K18893]
ETAC_10460  cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16012]
ETAC_10455  cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013]
ETAC_06945  ABC transporter ATP-binding protein [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00315  Spermidine
C00320  Thiosulfate
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00719  Betaine
C00753  Tungsten
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  D-Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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