KEGG   PATHWAY: eum00520
Entry
eum00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
eum00520  Amino sugar and nucleotide sugar metabolism
eum00520

Module
eum_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:eum00520]
eum_M00554  Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:eum00520]
eum_M00761  Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:eum00520]
eum_M00909  UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:eum00520]
Other DBs
GO: 0006040 0009225
Organism
Escherichia coli O17:K52:H18 UMN026 (ExPEC) [GN:eum]
Gene
ECUMN_1285  nagZ; beta N-acetyl-glucosaminidase [KO:K01207] [EC:3.2.1.52]
ECUMN_2739  crr; glucose-specific enzyme IIA component of PTS [KO:K02777] [EC:2.7.1.-]
ECUMN_0764  nagE; fused N-acetyl glucosamine specific PTS enzymes: IIC component; IIB component; IIA component [KO:K02804] [EC:2.7.1.193]
ECUMN_1297  ycfX; N-acetyl-D-glucosamine kinase [KO:K00884] [EC:2.7.1.59]
ECUMN_0762  nagA; N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
ECUMN_0763  nagB; glucosamine-6-phosphate deaminase [KO:K02564] [EC:3.5.99.6]
ECUMN_0432  mak; manno(fructo)kinase [KO:K00847] [EC:2.7.1.4]
ECUMN_2691  cscK; Fructokinase [KO:K00847] [EC:2.7.1.4]
ECUMN_4259  glmS; L-glutamine:D-fructose-6-phosphate aminotransferase [KO:K00820] [EC:2.6.1.16]
ECUMN_3656  glmM; phosphoglucosamine mutase [KO:K03431] [EC:5.4.2.10]
ECUMN_4260  glmU; fused N-acetyl glucosamine-1-phosphate uridyltransferase; glucosamine-1-phosphate acetyl transferase [KO:K04042] [EC:2.7.7.23 2.3.1.157]
ECUMN_2750  murP; putative fused PTS enzymes: IIB component; IIC component [KO:K11192] [EC:2.7.1.192]
ECUMN_2749  yfeU; putative PTS component; possibly regulatory [KO:K07106] [EC:4.2.1.126]
ECUMN_1931  anmK; anhydro-N-acetylmuramic acid kinase [KO:K09001] [EC:2.7.1.170]
ECUMN_3669  murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
ECUMN_4498.6  murB; UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding [KO:K00075] [EC:1.3.1.98]
ECUMN_3696  nanK; putative N-acetylmannosamine kinase [KO:K00885] [EC:2.7.1.60]
ECUMN_3384  nanK; N-acetylmannosamine kinase 2 [KO:K00885] [EC:2.7.1.60]
ECUMN_3697  nanE; putative N-acetylmannosamine-6-P epimerase [KO:K01788] [EC:5.1.3.9]
ECUMN_3385  N-acetylneuraminate lyase 2 [KO:K01639] [EC:4.1.3.3]
ECUMN_3699  nanA; N-acetylneuraminate lyase [KO:K01639] [EC:4.1.3.3]
ECUMN_4311  rffE; UDP-N-acetyl glucosamine-2-epimerase [KO:K01791] [EC:5.1.3.14]
ECUMN_4312  rffD; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [KO:K02472] [EC:1.1.1.336]
ECUMN_2596  yfbG; fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase [KO:K10011] [EC:2.1.2.13 1.1.1.305]
ECUMN_2594  yfbE; uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent [KO:K07806] [EC:2.6.1.87]
ECUMN_2595  yfbF; undecaprenyl phosphate-L-Ara4FN transferase [KO:K10012] [EC:2.4.2.53]
ECUMN_2597  yfbH; conserved hypothetical protein [KO:K13014] [EC:3.5.1.-]
ECUMN_1279  ptsG; fused glucose-specific PTS enzymes: IIBcomponent; IIC component [KO:K02779] [EC:2.7.1.199]
ECUMN_1911  malX; fused maltose and glucose-specific PTS enzymes: IIB and IIC components [KO:K02791] [EC:2.7.1.199 2.7.1.208]
ECUMN_2966  ptsG; PTS system glucose-specific EIIABC component from bacteriophage origin [KO:K20118] [EC:2.7.1.199]
ECUMN_2718  glk; glucokinase [KO:K00845] [EC:2.7.1.2]
ECUMN_0774  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECUMN_1533  galU; glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
ECUMN_2378  galF; putative subunit with GalU [KO:K00963] [EC:2.7.7.9]
ECUMN_2370  ugd; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
ECUMN_0841  galK; galactokinase [KO:K00849] [EC:2.7.1.6]
ECUMN_0842  galT; galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
ECUMN_0843  galE; UDP-galactose-4-epimerase [KO:K01784] [EC:5.1.3.2]
ECUMN_2109  manX; fused mannose-specific PTS enzymes: IIA component; IIB component [KO:K02794] [EC:2.7.1.191]
ECUMN_2110  manY; mannose-specific enzyme IIC component of PTS [KO:K02795]
ECUMN_2111  manZ; mannose-specific enzyme IID component of PTS [KO:K02796]
ECUMN_4558  pgi; glucosephosphate isomerase [KO:K01810] [EC:5.3.1.9]
ECUMN_2965  putative Glucose-6-phosphate isomerase from bacteriophage origin [KO:K06859] [EC:5.3.1.9]
ECUMN_1902  manA; mannose-6-phosphate isomerase [KO:K01809] [EC:5.3.1.8]
ECUMN_2384  cpsG; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
ECUMN_2374  manB; Phosphomannomutase (PMM) [KO:K01840] [EC:5.4.2.8]
ECUMN_2385  cpsB; mannose-1-phosphate guanyltransferase [KO:K00971] [EC:2.7.7.13]
ECUMN_2375  cpsB; Mannose-1-phosphate guanylyltransferase [GDP] (GDP-mannose pyrophosphorylase) (GMP) [KO:K00971] [EC:2.7.7.13]
ECUMN_2389  gmd; GDP-D-mannose dehydratase, NAD(P)-binding [KO:K01711] [EC:4.2.1.47]
ECUMN_2388  fcl; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase [KO:K02377] [EC:1.1.1.271]
ECUMN_3894  glgC; glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00128  CMP-N-acetylneuraminate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00270  N-Acetylneuraminate
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C00996  Ferricytochrome b5
C00999  Ferrocytochrome b5
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01219  CDP-4-dehydro-6-deoxy-D-glucose
C01222  GDP-4-dehydro-6-deoxy-D-mannose
C01623  UDP-apiose
C01674  Chitobiose
C01788  CDP-abequose
C02199  UDP-L-rhamnose
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02977  GDP-6-deoxy-D-talose
C02985  L-Fucose 1-phosphate
C03117  GDP-6-deoxy-D-mannose
C03410  N-Glycoloyl-neuraminate
C03598  CDP-3,6-dideoxy-D-glucose
C03599  CDP-3,6-dideoxy-D-mannose
C03691  CMP-N-glycoloylneuraminate
C03733  UDP-alpha-D-galactofuranose
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04089  UDP-4-dehydro-6-deoxy-D-glucose
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04297  CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573  UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613  UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630  UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06240  UDP-N-acetyl-D-mannosaminouronate
C06241  N-Acetylneuraminate 9-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C13952  UDP-N-acetyl-D-galactosaminuronic acid
C15925  GDP-L-gulose
C16153  UDP-L-Ara4N
C16154  UDP-L-Ara4FN
C16155  UDP-L-Ara4O
C16156  Undecaprenyl phosphate alpha-L-Ara4FN
C16157  Undecaprenyl phosphate alpha-L-Ara4N
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C17326  CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C17327  CDP-ascarylose
C17328  UDP-4-keto-rhamnose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19725  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C19823  UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961  UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971  UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972  2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20082  Pseudaminic acid
C20083  CMP-pseudaminic acid
C20357  UDP-N,N'-diacetylbacillosamine
C20359  UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395  UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20418  N,N'-Diacetyllegionaminate
C20419  CMP-N,N'-diacetyllegionaminate
C20424  2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20638  GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672  GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20934  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C21383  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384  CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
PMID:10931327
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
PMID:10984043
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
PMID:11447132
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
PMID:12562791
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
PMID:14450717
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
PMID:15134748
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
PMID:15489439
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
PMID:15695810
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
PMID:15809294
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
PMID:16237198
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
PMID:16277754
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
PMID:16452451
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
PMID:16995900
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
PMID:17085508
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
PMID:17190829
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
PMID:17827295
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
PMID:18199744
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
PMID:18304669
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
PMID:11479276
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
eum00010  Glycolysis / Gluconeogenesis
eum00040  Pentose and glucuronate interconversions
eum00051  Fructose and mannose metabolism
eum00052  Galactose metabolism
eum00053  Ascorbate and aldarate metabolism
eum00500  Starch and sucrose metabolism
eum00523  Polyketide sugar unit biosynthesis
eum00525  Acarbose and validamycin biosynthesis
eum00540  Lipopolysaccharide biosynthesis
eum00550  Peptidoglycan biosynthesis
KO pathway
ko00520   

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Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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