Entry
Name
GABAergic synapse - Felis catus (domestic cat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Felis catus (domestic cat) [GN:
fca ]
Gene
101083092 SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990 ]
101083348 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X2 [KO:K14207 ]
101096880 SLC32A1; vesicular inhibitory amino acid transporter isoform X1 [KO:K15015 ]
101098052 GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175 ]
100294524 GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175 ]
100286792 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175 ]
101093992 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175 ]
100286789 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175 ]
101090773 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175 ]
100286790 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X2 [KO:K05181 ]
101097640 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
101094237 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X2 [KO:K05181 ]
100286791 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186 ]
101099123 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186 ]
101094182 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X3 [KO:K05186 ]
101087589 GABRD; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184 ]
101095805 GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185 ]
101099698 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
101095468 GABRP; gamma-aminobutyric acid receptor subunit pi isoform X3 [KO:K05189 ]
101088631 HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647 ]
101083945 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
101094636 GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
101097365 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2 [KO:K08341 ]
101094365 TRAK2; trafficking kinesin-binding protein 2 isoform X2 [KO:K15374 ]
101090128 PLCL1; inactive phospholipase C-like protein 1 isoform X1 [KO:K15375 ]
101085617 SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967 ]
101093186 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190 ]
101093609 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
101082769 GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190 ]
101094827 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344 ]
101087362 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
101082923 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
101088394 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851 ]
101080870 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
654399 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
101093058 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
101099637 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615 ]
101092837 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
101100320 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
101089679 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
101101353 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [KO:K04534 ]
101086580 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
101093317 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
101084799 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
101091855 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
101081809 GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539 ]
101097491 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
101091560 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
101081928 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541 ]
111561761 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
101088219 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
101090817 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544 ]
111557526 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
101088915 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
101084346 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
101089378 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
101086526 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
101088476 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
101096184 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
101080818 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
101088066 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
101088087 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046 ]
101092834 SLC6A11; sodium- and chloride-dependent GABA transporter 3 isoform X1 [KO:K05044 ]
101088338 SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045 ]
101092169 SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
101093166 SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X2 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
fca00250 Alanine, aspartate and glutamate metabolism
KO pathway