KEGG   PATHWAY: gga04120
Entry
gga04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Gallus gallus (chicken)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
gga04120  Ubiquitin mediated proteolysis
gga04120

Other DBs
GO: 0016567
Organism
Gallus gallus (chicken) [GN:gga]
Gene
396190  UBC; polyubiquitin-C [KO:K04551]
101747587  UBB; polyubiquitin-B [KO:K04551]
395958  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
395796  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101750090  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
415784  UBA2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
426073  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X4 [KO:K10686] [EC:6.2.1.64]
422655  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
395672  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
100857678  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
100859413  UBE2C; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
416137  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X3 [KO:K06689] [EC:2.3.2.23]
422713  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
423641  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
420653  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
424122  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
776043  UBE2E2; ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
424015  UBE2F; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
770961  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
424837  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
416678  UBE2H; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
374123  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
395528  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
419421  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
428787  UBE2K; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
416769  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
100858073  UBE2L6; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
107049465  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
417898  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
417359  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
415356  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
100858564  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
427021  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
425483  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
427134  UBE2R2L; ubiquitin-conjugating enzyme E2 R2 isoform X2 [KO:K02207] [EC:2.3.2.23]
107050834  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
420185  UBE2W; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
419991  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
421463  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
418686  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
776286  UBE3B; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
420447  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
427809  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
416487  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
419145  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
420212  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
415868  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
424785  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
415406  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
374119  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
107055431  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
420252  UBR5; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
415367  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
418682  HERC2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
422514  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
423683  HERC4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
419758  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
419448  UBE4B; ubiquitin conjugation factor E4 B isoform X6 [KO:K10597] [EC:2.3.2.27]
426918  STUB1; STIP1 homology and U box-containing protein 1 [KO:K09561] [EC:2.3.2.27]
416775  PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [KO:K10598] [EC:5.2.1.8]
430767  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
422940  UBOX5; RING finger protein 37 [KO:K10600]
395609  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
374038  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
418406  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X2 [KO:K22517] [EC:2.3.2.27]
421577  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
374076  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
415302  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
100857563  PMLL; protein PML [KO:K10054] [EC:2.3.2.-]
423163  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
427144  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
429072  RFWD2; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
771726  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
374012  BIRC2; inhibitor of apoptosis protein [KO:K16060]
395280  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
419239  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
427514  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
416383  PIAS2; E3 SUMO-protein ligase PIAS2 [KO:K16063] [EC:2.3.2.-]
107055114  E3 SUMO-protein ligase PIAS3-like isoform X1 [KO:K16064] [EC:2.3.2.-]
420095  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
100859884  SYVN1; uncharacterized protein SYVN1 isoform X1 [KO:K10601] [EC:2.3.2.27]
107050103  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
428477  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
416660  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
373983  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
421202  FANCL; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
373920  MID1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
101748429  TRIM32; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
417628  TRIM37; E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
418001  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
420783  CUL1; cullin-1 [KO:K03347]
416319  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
416181  FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362]
423854  BTRC; F-box/WD repeat-containing protein 1A isoform X4 [KO:K03362]
427437  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
419074  F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
422481  FBXW7; F-box/WD repeat-containing protein 7 [KO:K10260]
419495  FBXO2; F-box only protein 2 [KO:K10099]
431586  FBXO4; F-box only protein 4 [KO:K10291]
420467  CUL2; cullin-2 [KO:K03870]
420187  ELOC; elongin-C [KO:K03872]
416117  VHL; von Hippel-Lindau disease tumor suppressor isoform X2 [KO:K03871]
424804  CUL3; cullin-3 [KO:K03869]
100858752  KEAP1; LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1 [KO:K10456]
422226  KLHL9; kelch-like protein 13 [KO:K10447]
101748328  kelch-like protein 9 [KO:K10447]
419536  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
423664  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
107056274  rho-related BTB domain-containing protein 1-like isoform X1 [KO:K07868]
422364  CUL4B; cullin-4B [KO:K10609]
418744  CUL4A; cullin-4A isoform X1 [KO:K10609]
374050  DDB1; DNA damage-binding protein 1 [KO:K10610]
423185  DDB2; DNA damage-binding protein 2 [KO:K10140]
427153  ERCC8; DNA excision repair protein ERCC-8 isoform X2 [KO:K10570]
415497  DET1; DET1 homolog isoform X1 [KO:K10571]
424781  RNF7; RING-box protein 2 [KO:K10611]
418969  CUL5; cullin-5 isoform X1 [KO:K10612]
416630  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
395299  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
417024  FBXW8; F-box/WD repeat-containing protein 8 isoform X2 [KO:K10264]
417258  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
424563  CDC20; cell division cycle protein 20 homolog [KO:K03363]
395297  FZR1; fizzy-related protein homolog [KO:K03364]
421228  ANAPC1; anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
419960  CDC27; cell division cycle protein 27 homolog [KO:K03350]
422805  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
416842  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
418735  CDC16; cell division cycle protein 16 homolog [KO:K03353]
416838  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
771857  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
422461  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
417269  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
769605  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100857405  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
423708  ANAPC16; anaphase-promoting complex subunit 16 isoform X2 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
gga03050  Proteasome
KO pathway
ko04120   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (135)   
   KEGG GENES (135)   
All databases (136)   

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