KEGG   PATHWAY: ggo05330
Entry
ggo05330                    Pathway                                
Name
Allograft rejection - Gorilla gorilla gorilla (western lowland gorilla)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
Pathway map
ggo05330  Allograft rejection
ggo05330

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101153360  patr class I histocompatibility antigen, alpha chain E [KO:K06751]
101141279  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor [KO:K06751]
101143843  MHC-G; HLA class I histocompatibility antigen, alpha chain G-like precursor [KO:K06751]
101142998  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain isoform X1 [KO:K06751]
101142134  LOW QUALITY PROTEIN: putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
115930068  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
101144465  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-3 alpha chain-like [KO:K06751]
115934970  class I histocompatibility antigen, Gogo-A*0401 alpha chain isoform X1 [KO:K06751]
101135313  uncharacterized protein LOC101135313 [KO:K10785]
101137374  uncharacterized protein LOC101137374 [KO:K10785]
101149580  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
101139275  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
101127818  CD28; T-cell-specific surface glycoprotein CD28 isoform X2 [KO:K06470]
101150677  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
101141274  IL12B; interleukin-12 subunit beta [KO:K05425]
101137781  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101152441  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
101141935  PRF1; perforin-1 isoform X2 [KO:K07818]
101133374  granzyme B isoform X1 [KO:K01353] [EC:3.4.21.79]
101128237  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101133052  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
101133995  HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1 [KO:K06752]
101134815  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
101137108  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101139685  HLA class II histocompatibility antigen, DM alpha chain isoform X4 [KO:K06752]
101140024  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101141025  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101141395  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109027175  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
101131235  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
101140641  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101132303  HLA class II histocompatibility antigen, DR beta 3 chain [KO:K06752]
115935014  HLA class II histocompatibility antigen, DRB1-8 beta chain isoform X1 [KO:K06752]
115934980  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
101132394  IL2; interleukin-2 [KO:K05429]
101152672  CD40LG; CD40 ligand isoform X1 [KO:K03161]
101126651  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
101151755  IFNG; interferon gamma [KO:K04687]
101140015  IL4; interleukin-4 isoform X1 [KO:K05430]
101138467  IL5; interleukin-5 [KO:K05428]
101130439  IL10; interleukin-10 [KO:K05443]
109023156  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
115930553  uncharacterized protein LOC115930553 [KO:K06856]
115930559  uncharacterized protein LOC115930559 [KO:K06856]
101133851  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
Compound
C00533  Nitric oxide
Reference
PMID:10746853
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
PMID:12023610
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001
Reference
PMID:17445565
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
PMID:14710779
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
PMID:10571983
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
PMID:10331992
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou
Reference
PMID:10667806
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
PMID:12216939
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
PMID:12563298
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
Related
pathway
ggo04210  Apoptosis
ggo04514  Cell adhesion molecules
ggo04610  Complement and coagulation cascades
ggo04612  Antigen processing and presentation
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
KO pathway
ko05330   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (45)   
   KEGG GENES (45)   
All databases (46)   

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