KEGG   PATHWAY: gva03440Help
Entry
gva03440                    Pathway                                

Name
Homologous recombination - Gardnerella vaginalis 409-05
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
gva03440  Homologous recombination
gva03440

Ortholog table
Module
gva_M00260  DNA polymerase III complex, bacteria [PATH:gva03440]
Other DBs
BSID: 133948
GO: 0000724
Organism
Gardnerella vaginalis 409-05 [GN:gva]
Gene
HMPREF0424_0309  single-strand binding family protein [KO:K03111]
HMPREF0424_1076  single-strand binding family protein [KO:K03111]
HMPREF0424_0043  recF; DNA replication and repair protein RecF [KO:K03629]
HMPREF0424_0450  recO; DNA repair protein RecO [KO:K03584]
HMPREF0424_0127  recR; recombination protein RecR [KO:K06187]
HMPREF0424_1021  recA; RecA protein [KO:K03553]
HMPREF0424_0617  polA; DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
HMPREF0424_0837  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
HMPREF0424_0836  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
HMPREF0424_0838  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
HMPREF0424_0734  hypothetical protein [KO:K03655] [EC:3.6.4.12]
HMPREF0424_0316  putative ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
HMPREF0424_0499  hypothetical protein [KO:K03655] [EC:3.6.4.12]
HMPREF0424_1114  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
HMPREF0424_0044  dnaN; DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
HMPREF0424_0126  dnaX; DNA polymerase III, subunit gamma and tau [KO:K02343] [EC:2.7.7.7]
HMPREF0424_0941  putative DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
HMPREF0424_1271  DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
HMPREF0424_0468  exonuclease [KO:K02342] [EC:2.7.7.7]
HMPREF0424_0912  putative primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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