KEGG   PATHWAY: hde03440
Entry
hde03440                    Pathway                                
Name
Homologous recombination - Candidatus Hamiltonella defensa (Acyrthosiphon pisum)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
hde03440  Homologous recombination
hde03440

Other DBs
GO: 0000724
Organism
Candidatus Hamiltonella defensa (Acyrthosiphon pisum) [GN:hde]
Gene
HDEF_0155  recJ; ssDNA exonuclease, 5' --> 3'-specific, Mg-dependent [KO:K07462] [EC:3.1.-.-]
HDEF_1536  ssb; single-stranded DNA-binding protein [KO:K03111]
HDEF_0575  putative single-strand DNA-binding protein [KO:K03111]
HDEF_0919  putative single-strand DNA-binding protein [KO:K03111]
HDEF_0534  recO; gap repair protein, part of RecFOR complex [KO:K03584]
HDEF_2089  recR; gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction [KO:K06187]
HDEF_0025  recA; DNA strand exchange and recombination protein with protease and nuclease activity [KO:K03553]
HDEF_0863  polA; multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); 3'->5' polymerase; 3'->5' exonuclease (C-terminal) [KO:K02335] [EC:2.7.7.7]
HDEF_1940  ruvA; Holliday junction helicase, subunit A [KO:K03550]
HDEF_1939  ruvB; Holliday junction helicase, subunit B [KO:K03551] [EC:5.6.2.4]
HDEF_0870  ruvC; Holliday junction nuclease [KO:K01159] [EC:3.1.21.10]
HDEF_0627  recG; DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration [KO:K03655] [EC:5.6.2.4]
HDEF_0033  recB; exonuclease V, beta chain with recC and recD: 5' and 3' nuclease, ATPase, recombinase, helicase [KO:K03582] [EC:3.1.11.5]
HDEF_0034  recC; exonuclease V, gamma chain with recB and recD: 5' and 3' nuclease, ATPase, recombinase, helicase [KO:K03583] [EC:3.1.11.5]
HDEF_0032  recD; exonuclease V (RecBCD complex), alpha chain [KO:K03581] [EC:3.1.11.5]
HDEF_0209  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
HDEF_1740  dnaN; DNA polymerase III, beta-subunit [KO:K02338] [EC:2.7.7.7]
HDEF_2087  dnaX; DNA polymerase III, tau and gamma subunits; DNA elongation factor III [KO:K02343] [EC:2.7.7.7]
HDEF_2040  holA; DNA polymerase III, delta subunit, probably ATP hydrolase [KO:K02340] [EC:2.7.7.7]
HDEF_0452  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
HDEF_0683  dnaQ_1; DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function [KO:K02342] [EC:2.7.7.7]
HDEF_0220  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
HDEF_0500  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
HDEF_0504  priA; primosomal protein N' (factor Y) directs replication fork assembly at D-loops, ATP-dependent [KO:K04066] [EC:5.6.2.4]
HDEF_0584  priB; primosomal replication protein N [KO:K02686]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG GENES (25)   
All databases (26)   

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