KEGG   PATHWAY: hoh03440Help
Entry
hoh03440                    Pathway                                

Name
Homologous recombination - Haliangium ochraceum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
hoh03440  Homologous recombination
hoh03440

Ortholog table
Module
hoh_M00260  DNA polymerase III complex, bacteria [PATH:hoh03440]
Other DBs
BSID: 126460
GO: 0000724
Organism
Haliangium ochraceum [GN:hoh]
Gene
Hoch_2398  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Hoch_5071  single-strand binding protein [KO:K03111]
Hoch_0003  DNA replication and repair protein RecF [KO:K03629]
Hoch_3559  DNA repair protein RecO [KO:K03584]
Hoch_6868  recombination protein RecR [KO:K06187]
Hoch_5903  recA protein [KO:K03553]
Hoch_4612  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Hoch_3909  Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
Hoch_3908  Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
Hoch_3910  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
Hoch_2326  DEAD/DEAH box helicase domain protein [KO:K03655] [EC:3.6.4.12]
Hoch_4879  Exodeoxyribonuclease V [KO:K03582] [EC:3.1.11.5]
Hoch_1784  Exodeoxyribonuclease V [KO:K03583] [EC:3.1.11.5]
Hoch_5748  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Hoch_5137  Exodeoxyribonuclease V [KO:K03581] [EC:3.1.11.5]
Hoch_4061  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Hoch_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Hoch_6870  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Hoch_2328  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Hoch_6483  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Hoch_1023  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Hoch_0637  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Hoch_6083  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Hoch_0966  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Hoch_5549  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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