KEGG   PATHWAY: hpt03440Help
Entry
hpt03440                    Pathway                                

Name
Homologous recombination - Helicobacter pylori Sat464
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
hpt03440  Homologous recombination
hpt03440

Ortholog table
Module
hpt_M00260  DNA polymerase III complex, bacteria [PATH:hpt03440]
Other DBs
BSID: 601482
GO: 0000724
Organism
Helicobacter pylori Sat464 [GN:hpt]
Gene
HPSAT_01725  single-stranded-DNA specific exonuclease [KO:K07462] [EC:3.1.-.-]
HPSAT_06005  single-stranded DNA-binding protein [KO:K03111]
HPSAT_04525  recR; recombination protein RecR [KO:K06187]
HPSAT_00735  recA; recombinase A [KO:K03553]
HPSAT_07070  DNA polymerase I (polA) [KO:K02335] [EC:2.7.7.7]
HPSAT_02130  hypothetical protein [KO:K02335] [EC:2.7.7.7]
HPSAT_04335  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
HPSAT_01950  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
HPSAT_02345  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
HPSAT_07325  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
HPSAT_07020  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
HPSAT_04260  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
HPSAT_03225  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
HPSAT_06015  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
HPSAT_05930  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
HPSAT_07470  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
HPSAT_05085  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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