KEGG   PATHWAY: hsa00100Help
Entry
hsa00100                    Pathway                                

Name
Steroid biosynthesis - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
hsa00100  Steroid biosynthesis
hsa00100

Ortholog table
Module
hsa_M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol [PATH:hsa00100]
hsa_M00103  Cholecalciferol biosynthesis [PATH:hsa00100]
Disease
H00148  Lysosomal acid lipase deficiency
H00161  Smith-Lemli-Opitz syndrome
H00496  Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
H00617  Desmosterolosis
H01143  Vitamin D-dependent rickets
H01194  X-linked chondrodysplasia punctata
H01281  Lathosterolosis
H01371  Hypercalcemia infantile
H01917  CK syndrome
Drug
D01202  Melinamide (JAN)
D03012  Avasimibe (USAN/INN)
D03734  Eldacimibe (USAN/INN)
D03735  Lecimibide (USAN)
Other DBs
BSID: 82937
GO: 0016126
Organism
Homo sapiens (human) [GN:hsa]
Gene
2222  FDFT1; farnesyl-diphosphate farnesyltransferase 1 [KO:K00801] [EC:2.5.1.21]
6713  SQLE; squalene epoxidase [KO:K00511] [EC:1.14.14.17]
4047  LSS; lanosterol synthase [KO:K01852] [EC:5.4.99.7]
1595  CYP51A1; cytochrome P450 family 51 subfamily A member 1 [KO:K05917] [EC:1.14.13.70]
7108  TM7SF2; transmembrane 7 superfamily member 2 [KO:K00222] [EC:1.3.1.70]
6307  MSMO1; methylsterol monooxygenase 1 [KO:K07750] [EC:1.14.18.9]
50814  NSDHL; NAD(P) dependent steroid dehydrogenase-like [KO:K07748] [EC:1.1.1.170]
51478  HSD17B7; hydroxysteroid 17-beta dehydrogenase 7 [KO:K13373] [EC:1.1.1.270 1.1.1.62]
10682  EBP; EBP, cholestenol delta-isomerase [KO:K01824] [EC:5.3.3.5]
1718  DHCR24; 24-dehydrocholesterol reductase [KO:K09828] [EC:1.3.1.- 1.3.1.72]
6309  SC5D; sterol-C5-desaturase [KO:K00227] [EC:1.14.19.20]
1717  DHCR7; 7-dehydrocholesterol reductase [KO:K00213] [EC:1.3.1.21]
3988  LIPA; lipase A, lysosomal acid type [KO:K01052] [EC:3.1.1.13]
1056  CEL; carboxyl ester lipase [KO:K12298] [EC:3.1.1.3 3.1.1.13]
8435  SOAT2; sterol O-acyltransferase 2 [KO:K00637] [EC:2.3.1.26]
6646  SOAT1; sterol O-acyltransferase 1 [KO:K00637] [EC:2.3.1.26]
120227  CYP2R1; cytochrome P450 family 2 subfamily R member 1 [KO:K07419] [EC:1.14.14.24]
1594  CYP27B1; cytochrome P450 family 27 subfamily B member 1 [KO:K07438] [EC:1.14.15.18]
1591  CYP24A1; cytochrome P450 family 24 subfamily A member 1 [KO:K07436] [EC:1.14.15.16]
Compound
C00187  Cholesterol
C00448  trans,trans-Farnesyl diphosphate
C00751  Squalene
C01054  (S)-2,3-Epoxysqualene
C01164  7-Dehydrocholesterol
C01189  Lathosterol
C01561  Calcidiol
C01673  Calcitriol
C01694  Ergosterol
C01724  Lanosterol
C01753  beta-Sitosterol
C01789  Campesterol
C01802  Desmosterol
C01902  Cycloartenol
C01943  Obtusifoliol
C02141  Cycloeucalenol
C02530  Cholesterol ester
C03428  Presqualene diphosphate
C03845  5alpha-Cholest-8-en-3beta-ol
C04525  Fecosterol
C05103  4alpha-Methylzymosterol
C05107  7-Dehydrodesmosterol
C05108  14-Demethyllanosterol
C05109  24,25-Dihydrolanosterol
C05437  Zymosterol
C05439  5alpha-Cholesta-7,24-dien-3beta-ol
C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
C05441  Vitamin D2
C05442  Stigmasterol
C05443  Vitamin D3
C07712  Secalciferol
C08813  Brassicasterol
C08821  Isofucosterol
C08830  24-Methylenecycloartanol
C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
C11522  24-Methylenelophenol
C11523  24-Ethylidenelophenol
C15776  4alpha-Methylfecosterol
C15777  Episterol
C15778  5,7,24(28)-Ergostatrienol
C15780  5-Dehydroepisterol
C15781  24-Methylenecholesterol
C15782  Delta7-Avenasterol
C15783  5-Dehydroavenasterol
C15808  4alpha-Methylzymosterol-4-carboxylate
C15816  3-Keto-4-methylzymosterol
C15915  4,4-Dimethyl-5alpha-cholesta-8-en-3beta-ol
C18231  Calcitetrol
C21106  24-epi-Campesterol
Reference
  Authors
Koshiba K, Kamiya Y.
  Title
[Atarasii Syokubutuhorumon no Kagaku] (In Japanese)
  Journal
Koudansya saientific:199-138 (2002)
Reference
  Authors
Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D.
  Title
Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.
  Journal
Plant Cell 18:1008-22 (2006)
DOI:10.1105/tpc.105.036012
Reference
  Authors
Lange BM, Ghassemian M.
  Title
Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
  Journal
Plant Mol Biol 51:925-48 (2003)
DOI:10.1023/A:1023005504702
KO pathway
ko00100   

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