KEGG   PATHWAY: hsa00360Help
Entry
hsa00360                    Pathway                                

Name
Phenylalanine metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
hsa00360  Phenylalanine metabolism
hsa00360

Ortholog table
Disease
H00165  Tyrosinemia
Drug
D00505  Phenelzine sulfate (USP)
D00826  Tranylcypromine sulfate (USP XXI)
D01888  Safrazine hydrochloride (JAN)
D02559  Toloxatone (INN)
D02560  Brofaromine (INN)
D02561  Moclobemide (USAN/INN)
D02563  Befloxatone (INN)
D02579  Iproniazid (INN)
D02580  Isocarboxazid (INN)
D02581  Cimoxatone (INN)
D03239  Ladostigil tartrate (USAN)
D03248  Clorgiline (INN)
D03409  Caroxazone (USAN/INN)
D05033  Milacemide hydrochloride (USAN)
D05177  Nitisinone (JAN/USAN/INN)
D07337  Nialamide (INN)
D07338  Iproclozide (INN)
D08085  Iproniazid phosphate
D08349  Phenelzine (BAN)
D08392  Pirlindole (INN)
D08393  Pirlindole hydrochloride
D08625  Tranylcypromine (INN)
Other DBs
BSID: 82960
GO: 0006558
Organism
Homo sapiens (human) [GN:hsa]
Gene
5053  PAH; phenylalanine hydroxylase [KO:K00500] [EC:1.14.16.1]
1644  DDC; dopa decarboxylase [KO:K01593] [EC:4.1.1.105 4.1.1.28]
8639  AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
314  AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
4129  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
4128  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
221  ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]
222  ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]
220  ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K00129] [EC:1.2.1.5]
218  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
2805  GOT1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
2806  GOT2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
6898  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
259307  IL4I1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
3242  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
4282  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
10249  GLYAT; glycine-N-acyltransferase [KO:K00628] [EC:2.3.1.71 2.3.1.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00156  4-Hydroxybenzoate
C00166  Phenylpyruvate
C00180  Benzoate
C00223  p-Coumaroyl-CoA
C00323  Caffeoyl-CoA
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00630  2-Methylpropanoyl-CoA
C00642  4-Hydroxyphenylacetate
C00755  4-Hydroxy-3-methoxy-benzaldehyde
C00805  Salicylate
C00811  4-Coumarate
C01198  3-(2-Hydroxyphenyl)propanoate
C01575  Ephedrine
C01586  Hippurate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C02765  (+)-Pseudoephedrine
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04351  (R)-2-Methylimino-1-phenylpropan-1-ol
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05620  N-Acetyl-D-phenylalanine
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C06866  Capsaicin
C07086  Phenylacetic acid
C07303  4-Hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA
C08300  D-Cathine
C08301  D-Cathinone
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C16666  Vanillylamine
C16719  (-)-Norephedrine
C17268  Pyruvophenone
C18202  8-Methyl-6-nonenoic acid
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
KO pathway
ko00360   

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