PATHWAY: hsa03008 Help
Entry
Name
Ribosome biogenesis in eukaryotes - Homo sapiens (human)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
hsa03008 Ribosome biogenesis in eukaryotes
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
10171 RCL1; RNA terminal phosphate cyclase like 1 [KO:K11108 ]
10813 UTP14A; UTP14A small subunit processome component [KO:K14567 ]
1736 DKC1; dyskerin pseudouridine synthase 1 [KO:K11131 ] [EC:5.4.99.-]
22803 XRN2; 5'-3' exoribonuclease 2 [KO:K12619 ] [EC:3.1.13.-]
25996 REXO2; RNA exonuclease 2 [KO:K13288 ] [EC:3.1.-.-]
26851 SNORD3B-1; small nucleolar RNA, C/D box 3B-1 [KO:K14483 ]
27341 RRP7A; ribosomal RNA processing 7 homolog A [KO:K14545 ]
28987 NOB1; NIN1 (RPN12) binding protein 1 homolog [KO:K11883 ]
29107 NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285 ]
3692 EIF6; eukaryotic translation initiation factor 6 [KO:K03264 ]
4809 SNU13; small nuclear ribonucleoprotein 13 [KO:K12845 ]
51096 UTP18; UTP18 small subunit processome component [KO:K14553 ]
51119 SBDS; SBDS ribosome maturation factor [KO:K14574 ]
54464 XRN1; 5'-3' exoribonuclease 1 [KO:K12618 ] [EC:3.1.13.-]
55226 NAT10; N-acetyltransferase 10 [KO:K14521 ] [EC:2.3.1.-]
55272 IMP3; IMP U3 small nucleolar ribonucleoprotein 3 [KO:K14560 ]
55341 LSG1; large 60S subunit nuclear export GTPase 1 [KO:K14539 ] [EC:3.6.1.-]
55813 UTP6; UTP6 small subunit processome component [KO:K14557 ]
55916 NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285 ]
57455 REXO1; RNA exonuclease 1 homolog [KO:K14570 ] [EC:3.1.-.-]
5822 PWP2; PWP2 small subunit processome component [KO:K14558 ]
5901 RAN; RAN, member RAS oncogene family [KO:K07936 ]
6023 RMRP; RNA component of mitochondrial RNA processing endoribonuclease [KO:K14576 ]
6949 TCOF1; treacle ribosome biogenesis factor 1 [KO:K14562 ]
780852 SNORD3B-2; small nucleolar RNA, C/D box 3B-2 [KO:K14483 ]
79631 EFL1; elongation factor like GTPase 1 [KO:K14536 ] [EC:3.6.5.-]
81691 REXO5; RNA exonuclease 5 [KO:K14570 ] [EC:3.1.-.-]
84135 UTP15; UTP15 small subunit processome component [KO:K14549 ]
84916 UTP4; UTP4 small subunit processome component [KO:K14548 ]
92856 IMP4; IMP U3 small nucleolar ribonucleoprotein 4 [KO:K14561 ]
9724 UTP14C; UTP14C small subunit processome component [KO:K14567 ]
9790 BMS1; BMS1 ribosome biogenesis factor [KO:K14569 ]
Reference
Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
Title
When ribosomes go bad: diseases of ribosome biogenesis.
Journal
Reference
Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Journal
Reference
Authors
Strunk BS, Karbstein K
Title
Powering through ribosome assembly.
Journal
Reference
Authors
Granneman S, Baserga SJ
Title
Ribosome biogenesis: of knobs and RNA processing.
Journal
Reference
Authors
Kressler D, Hurt E, Bassler J
Title
Driving ribosome assembly.
Journal
Related pathway
KO pathway
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