KEGG   PATHWAY: hsa03013
Entry
hsa03013                    Pathway                                
Name
Nucleocytoplasmic transport - Homo sapiens (human)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
hsa03013  Nucleocytoplasmic transport
hsa03013

Drug
D11222  Selinexor (USAN/INN)
D11223  Verdinexor (USAN/INN)
D11406  Risdiplam (JAN/USAN/INN)
D11499  Eltanexor (USAN/INN)
D11837  Zotatifin (USAN/INN)
D12345  Obefazimod (USAN)
Other DBs
GO: 0050658
Organism
Homo sapiens (human) [GN:hsa]
Gene
100101267  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
10073  SNUPN; snurportin-1 [KO:K13151]
10189  ALYREF; THO complex subunit 4 [KO:K12881]
10250  SRRM1; serine/arginine repetitive matrix protein 1 isoform 2 [KO:K13171]
10284  SAP18; histone deacetylase complex subunit SAP18 isoform 1 [KO:K14324]
10482  NXF1; nuclear RNA export factor 1 isoform 1 [KO:K14284]
10526  IPO8; importin-8 isoform 1 [KO:K18755]
10527  IPO7; importin-7 [KO:K20223]
10762  NUP50; nuclear pore complex protein Nup50 isoform b [KO:K14295]
10921  RNPS1; RNA-binding protein with serine-rich domain 1 isoform a [KO:K14325]
11097  NUP42; nucleoporin NUP42 isoform 2 [KO:K14321]
11260  XPOT; exportin-T [KO:K14288]
11269  DDX19B; ATP-dependent RNA helicase DDX19B isoform 1 [KO:K18655] [EC:5.6.2.7]
129401  NUP35; nucleoporin NUP35 isoform a [KO:K14313]
1434  CSE1L; exportin-2 isoform 1 [KO:K18423]
1915  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
1917  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
22794  CASC3; protein CASC3 [KO:K14323]
22916  NCBP2; nuclear cap-binding protein subunit 2 isoform 1 [KO:K12883]
22985  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform 1 [KO:K12875]
23039  XPO7; exportin-7 isoform b [KO:K18460]
23165  NUP205; nuclear pore complex protein Nup205 isoform 1 [KO:K14310]
23214  XPO6; exportin-6 isoform 2 [KO:K25204]
23225  NUP210; nuclear pore membrane glycoprotein 210 precursor [KO:K14314]
23279  NUP160; nuclear pore complex protein Nup160 isoform 1 [KO:K14303]
23511  NUP188; nucleoporin NUP188 [KO:K14311]
23534  TNPO3; transportin-3 isoform 1 [KO:K15436]
23633  KPNA6; importin subunit alpha-7 [KO:K15042]
23636  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
25909  AHCTF1; protein ELYS isoform 2 [KO:K25129]
26019  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
2733  GLE1; mRNA export factor GLE1 isoform 1 [KO:K18723]
29107  NXT1; NTF2-related export protein 1 [KO:K14285]
30000  TNPO2; transportin-2 isoform 1 [KO:K18727]
348995  NUP43; nucleoporin Nup43 [KO:K14305]
3836  KPNA1; importin subunit alpha-5 [KO:K23940]
3837  KPNB1; importin subunit beta-1 isoform 1 [KO:K14293]
3838  KPNA2; importin subunit alpha-1 [KO:K15043]
3839  KPNA3; importin subunit alpha-4 [KO:K23583]
3840  KPNA4; importin subunit alpha-3 [KO:K23583]
3841  KPNA5; importin subunit alpha-6 isoform b [KO:K15042]
3842  TNPO1; transportin-1 isoform 1 [KO:K18752]
3843  IPO5; importin-5 [KO:K20222]
387082  SUMO4; small ubiquitin-related modifier 4 [KO:K12160]
392517  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
402569  KPNA7; importin subunit alpha-8 [KO:K15043]
4116  MAGOH; protein mago nashi homolog [KO:K12877]
4686  NCBP1; nuclear cap-binding protein subunit 1 isoform 1 [KO:K12882]
4927  NUP88; nuclear pore complex protein Nup88 isoform 2 [KO:K14318]
4928  NUP98; nuclear pore complex protein Nup98-Nup96 isoform 6 precursor [KO:K14297]
51068  NMD3; 60S ribosomal export protein NMD3 isoform 2 [KO:K07562]
51194  IPO11; importin-11 isoform 2 [KO:K25201]
51808  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
53371  NUP54; nucleoporin p54 isoform 1 [KO:K14308]
5411  PNN; pinin [KO:K13114]
55110  MAGOHB; protein mago nashi homolog 2 isoform 1 [KO:K12877]
55161  TMEM33; transmembrane protein 33 [KO:K20724]
55308  DDX19A; ATP-dependent RNA helicase DDX19A isoform 1 [KO:K18655] [EC:5.6.2.7]
55705  IPO9; importin-9 [KO:K20224]
55706  NDC1; nucleoporin NDC1 isoform 1 [KO:K14315]
55746  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
55916  NXT2; NTF2-related export protein 2 isoform 2 [KO:K14285]
56000  NXF3; nuclear RNA export factor 3 [KO:K14284]
56001  NXF2; nuclear RNA export factor 2 [KO:K14284]
57122  NUP107; nuclear pore complex protein Nup107 isoform 1 [KO:K14301]
57187  THOC2; THO complex subunit 2 isoform 1 [KO:K12879]
57510  XPO5; exportin-5 [KO:K14289]
5901  RAN; GTP-binding nuclear protein Ran isoform 1 [KO:K07936]
5903  RANBP2; E3 SUMO-protein ligase RanBP2 isoform 1 [KO:K12172] [EC:2.3.2.-]
5905  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
59343  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
5976  UPF1; regulator of nonsense transcripts 1 isoform 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
6396  SEC13; protein SEC13 homolog isoform 1 [KO:K14004]
64328  XPO4; exportin-4 isoform 1 [KO:K25203]
64901  RANBP17; ran-binding protein 17 [KO:K24115]
65109  UPF3B; regulator of nonsense transcripts 3B isoform 1 [KO:K14328]
65110  UPF3A; regulator of nonsense transcripts 3A isoform hUpf3p [KO:K14328]
6612  SUMO3; small ubiquitin-related modifier 3 isoform 1 precursor [KO:K12160]
6613  SUMO2; small ubiquitin-related modifier 2 isoform a precursor [KO:K12160]
7175  TPR; nucleoprotein TPR [KO:K09291]
728343  NXF2B; nuclear RNA export factor 2 [KO:K14284]
7329  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
7341  SUMO1; small ubiquitin-related modifier 1 isoform a precursor [KO:K12160]
7514  XPO1; exportin-1 isoform 1 [KO:K14290]
79023  NUP37; nucleoporin Nup37 [KO:K14302]
7919  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
79228  THOC6; THO complex subunit 6 isoform 1 [KO:K13175]
79711  IPO4; importin-4 [KO:K20221]
79902  NUP85; nuclear pore complex protein Nup85 isoform 1 [KO:K14304]
80145  THOC7; THO complex subunit 7 isoform 1 [KO:K13176]
8021  NUP214; nuclear pore complex protein Nup214 isoform 2 [KO:K14317]
8086  AAAS; aladin isoform 1 [KO:K14320]
81929  SEH1L; nucleoporin SEH1 isoform 2 [KO:K14299]
84305  PYM1; partner of Y14 and mago isoform 1 [KO:K14294]
84321  THOC3; THO complex subunit 3 isoform 1 [KO:K12880]
8480  RAE1; mRNA export factor RAE1 [KO:K14298]
8563  THOC5; THO complex subunit 5 [KO:K13174]
91181  NUP210L; nuclear pore membrane glycoprotein 210-like isoform 1 precursor [KO:K14314]
94026  POM121L2; POM121-like protein 2 [KO:K14316]
9631  NUP155; nuclear pore complex protein Nup155 isoform 1 [KO:K14312]
9670  IPO13; importin-13 [KO:K25202]
9688  NUP93; nuclear pore complex protein Nup93 isoform 1 [KO:K14309]
9775  EIF4A3; eukaryotic initiation factor 4A-III isoform 1 [KO:K13025] [EC:5.6.2.7]
9818  NUP58; nucleoporin p58/p45 isoform a [KO:K14307]
9883  POM121; nuclear envelope pore membrane protein POM 121 isoform 4 [KO:K14316]
9939  RBM8A; RNA-binding protein 8A [KO:K12876]
9972  NUP153; nuclear pore complex protein Nup153 isoform 2 [KO:K14296]
9984  THOC1; THO complex subunit 1 [KO:K12878]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
hsa03015  mRNA surveillance pathway
KO pathway
ko03013   

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