KEGG   PATHWAY: hsa03013
Entry
hsa03013                    Pathway                                
Name
Nucleocytoplasmic transport - Homo sapiens (human)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
hsa03013  Nucleocytoplasmic transport
hsa03013

Network
nt06464  Amyotrophic lateral sclerosis
  Element
N01152  Nuclear export of mRNA
N01154  TDP-43-regulated splicing
N01156  FUS-regulated splicing
Drug
D11222  Selinexor (USAN/INN)
D11223  Verdinexor (USAN/INN)
D11406  Risdiplam (JAN/USAN/INN)
D11499  Eltanexor (USAN/INN)
D11837  Zotatifin (USAN/INN)
D12345  Obefazimod (USAN)
Other DBs
GO: 0050658
Organism
Homo sapiens (human) [GN:hsa]
Gene
100101267  POM121C; POM121 transmembrane nucleoporin C [KO:K14316]
10073  SNUPN; snurportin 1 [KO:K13151]
10189  ALYREF; Aly/REF export factor [KO:K12881]
10250  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
10284  SAP18; Sin3A associated protein 18 [KO:K14324]
10482  NXF1; nuclear RNA export factor 1 [KO:K14284]
10526  IPO8; importin 8 [KO:K18755]
10527  IPO7; importin 7 [KO:K20223]
10762  NUP50; nucleoporin 50 [KO:K14295]
10921  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
11097  NUP42; nucleoporin 42 [KO:K14321]
11260  XPOT; exportin for tRNA [KO:K14288]
11269  DDX19B; DEAD-box helicase 19B [KO:K18655] [EC:5.6.2.7]
129401  NUP35; nucleoporin 35 [KO:K14313]
1434  CSE1L; chromosome segregation 1 like [KO:K18423]
1915  EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
1917  EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]
22794  CASC3; CASC3 exon junction complex subunit [KO:K14323]
22916  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
22985  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
23039  XPO7; exportin 7 [KO:K18460]
23165  NUP205; nucleoporin 205 [KO:K14310]
23214  XPO6; exportin 6 [KO:K25204]
23225  NUP210; nucleoporin 210 [KO:K14314]
23279  NUP160; nucleoporin 160 [KO:K14303]
23511  NUP188; nucleoporin 188 [KO:K14311]
23534  TNPO3; transportin 3 [KO:K15436]
23633  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
23636  NUP62; nucleoporin 62 [KO:K14306]
25909  AHCTF1; AT-hook containing transcription factor 1 [KO:K25129]
26019  UPF2; UPF2 regulator of nonsense mediated mRNA decay [KO:K14327]
2733  GLE1; GLE1 RNA export mediator [KO:K18723]
29107  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
30000  TNPO2; transportin 2 [KO:K18727]
348995  NUP43; nucleoporin 43 [KO:K14305]
3836  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
3837  KPNB1; karyopherin subunit beta 1 [KO:K14293]
3838  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
3839  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
3840  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
3841  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
3842  TNPO1; transportin 1 [KO:K18752]
3843  IPO5; importin 5 [KO:K20222]
387082  SUMO4; small ubiquitin like modifier 4 [KO:K12160]
392517  NCBP2L; nuclear cap binding protein subunit 2 like [KO:K12883]
402569  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
4116  MAGOH; mago homolog, exon junction complex subunit [KO:K12877]
4686  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
4927  NUP88; nucleoporin 88 [KO:K14318]
4928  NUP98; nucleoporin 98 and 96 precursor [KO:K14297]
51068  NMD3; NMD3 ribosome export adaptor [KO:K07562]
51194  IPO11; importin 11 [KO:K25201]
51808  PHAX; phosphorylated adaptor for RNA export [KO:K14291]
53371  NUP54; nucleoporin 54 [KO:K14308]
5411  PNN; pinin, desmosome associated protein [KO:K13114]
55110  MAGOHB; mago homolog B, exon junction complex subunit [KO:K12877]
55161  TMEM33; transmembrane protein 33 [KO:K20724]
55308  DDX19A; DEAD-box helicase 19A [KO:K18655] [EC:5.6.2.7]
55705  IPO9; importin 9 [KO:K20224]
55706  NDC1; NDC1 transmembrane nucleoporin [KO:K14315]
55746  NUP133; nucleoporin 133 [KO:K14300]
55916  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
56000  NXF3; nuclear RNA export factor 3 [KO:K14284]
56001  NXF2; nuclear RNA export factor 2 [KO:K14284]
57122  NUP107; nucleoporin 107 [KO:K14301]
57187  THOC2; THO complex subunit 2 [KO:K12879]
57510  XPO5; exportin 5 [KO:K14289]
5901  RAN; RAN, member RAS oncogene family [KO:K07936]
5903  RANBP2; RAN binding protein 2 [KO:K12172] [EC:2.3.2.-]
5905  RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
59343  SENP2; SUMO specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
5976  UPF1; UPF1 RNA helicase and ATPase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
6396  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
64328  XPO4; exportin 4 [KO:K25203]
64901  RANBP17; RAN binding protein 17 [KO:K24115]
65109  UPF3B; UPF3B regulator of nonsense mediated mRNA decay [KO:K14328]
65110  UPF3A; UPF3A regulator of nonsense mediated mRNA decay [KO:K14328]
6612  SUMO3; small ubiquitin like modifier 3 [KO:K12160]
6613  SUMO2; small ubiquitin like modifier 2 [KO:K12160]
7175  TPR; translocated promoter region, nuclear basket protein [KO:K09291]
728343  NXF2B; nuclear RNA export factor 2B [KO:K14284]
7329  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
7341  SUMO1; small ubiquitin like modifier 1 [KO:K12160]
7514  XPO1; exportin 1 [KO:K14290]
79023  NUP37; nucleoporin 37 [KO:K14302]
7919  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
79228  THOC6; THO complex subunit 6 [KO:K13175]
79711  IPO4; importin 4 [KO:K20221]
79902  NUP85; nucleoporin 85 [KO:K14304]
80145  THOC7; THO complex subunit 7 [KO:K13176]
8021  NUP214; nucleoporin 214 [KO:K14317]
8086  AAAS; aladin WD repeat nucleoporin [KO:K14320]
81929  SEH1L; SEH1 like nucleoporin [KO:K14299]
84305  PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
84321  THOC3; THO complex subunit 3 [KO:K12880]
8480  RAE1; ribonucleic acid export 1 [KO:K14298]
8563  THOC5; THO complex subunit 5 [KO:K13174]
91181  NUP210L; nucleoporin 210 like [KO:K14314]
94026  POM121L2; POM121 transmembrane nucleoporin like 2 [KO:K14316]
9631  NUP155; nucleoporin 155 [KO:K14312]
9670  IPO13; importin 13 [KO:K25202]
9688  NUP93; nucleoporin 93 [KO:K14309]
9775  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
9818  NUP58; nucleoporin 58 [KO:K14307]
9883  POM121; POM121 transmembrane nucleoporin [KO:K14316]
9939  RBM8A; RNA binding motif protein 8A [KO:K12876]
9972  NUP153; nucleoporin 153 [KO:K14296]
9984  THOC1; THO complex subunit 1 [KO:K12878]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
hsa03015  mRNA surveillance pathway
KO pathway
ko03013   

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