KEGG   PATHWAY: hsa04310
Entry
hsa04310                    Pathway                                
Name
Wnt signaling pathway - Homo sapiens (human)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
hsa04310  Wnt signaling pathway
hsa04310

Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N00056  Wnt signaling pathway, Canonical pathway
N01427  WNT5A-ROR signaling pathway
N01440  Wnt signaling modulation, LGR/RSPO
N01441  Wnt signaling modulation, SOST/LRP4
N01442  Wnt signaling modulation, Wnt inhibitor
N01443  Wnt signaling modulation, Wnt acylation
N02010  Wnt signaling pathway, PCP pathway
Drug
D10094  Blosozumab (USAN)
D10156  Romosozumab (USAN)
D10410  Vantictumab (USAN/INN)
D11322  Umbralisib (USAN/INN)
D11323  Umbralisib tosylate (USAN)
D11369  Rosmantuzumab (USAN)
D11453  Nirogacestat hydrobromide (USAN)
D11758  Ipafricept (USAN/INN)
D12209  Ozuriftamab (USAN)
D12210  Ozuriftmab vedotin (USAN)
D12235  Osugacestat (USAN/INN)
D12416  Petosemtamab (USAN/INN)
D12445  Foscenvivint (JAN/INN)
D13031  Varegacestat (USAN/INN)
D13105  Setrusumab (USAN/INN)
D13162  Remigromig (USAN)
D13274  Relzasertideg (USAN)
Other DBs
GO: 0016055
Organism
Homo sapiens (human) [GN:hsa]
Gene
10023  FRAT1; proto-oncogene FRAT1 [KO:K03069]
102723796  TLE7; transducin-like enhancer protein 7 [KO:K04497]
102800317  TPTEP2-CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
10297  APC2; adenomatous polyposis coli protein 2 isoform 1 [KO:K02085]
11197  WIF1; wnt inhibitory factor 1 precursor [KO:K01691]
11211  FZD10; frizzled-10 precursor [KO:K02842]
122011  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
1387  CREBBP; CREB-binding protein isoform a [KO:K04498] [EC:2.3.1.48]
144165  PRICKLE1; prickle-like protein 1 [KO:K04511]
1452  CSNK1A1; casein kinase I isoform alpha isoform 2 [KO:K08957] [EC:2.7.11.1]
1454  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
1457  CSNK2A1; casein kinase II subunit alpha isoform a [KO:K03097] [EC:2.7.11.1]
1459  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
1460  CSNK2B; casein kinase II subunit beta isoform 1 [KO:K03115]
147111  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM precursor [KO:K19882] [EC:3.1.1.98]
147495  APCDD1; protein APCDD1 precursor [KO:K25812]
1487  CTBP1; C-terminal-binding protein 1 isoform 1 [KO:K04496] [EC:1.1.1.428]
1488  CTBP2; C-terminal-binding protein 2 isoform 1 [KO:K04496] [EC:1.1.1.428]
1499  CTNNB1; catenin beta-1 isoform 1 [KO:K02105]
1501  CTNND2; catenin delta-2 isoform 1 [KO:K23491]
164284  APCDD1L; protein APCDD1-like isoform 1 precursor [KO:K25812]
166336  PRICKLE2; prickle-like protein 2 [KO:K04511]
1855  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform 1 [KO:K02353]
1856  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
1857  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
1951  CELSR3; cadherin EGF LAG seven-pass G-type receptor 3 precursor [KO:K04602]
1952  CELSR2; cadherin EGF LAG seven-pass G-type receptor 2 precursor [KO:K04601]
2033  EP300; histone acetyltransferase p300 isoform 1 [KO:K04498] [EC:2.3.1.48]
2239  GPC4; glypican-4 precursor [KO:K08110]
22881  ANKRD6; ankyrin repeat domain-containing protein 6 isoform a [KO:K21435]
22943  DKK1; dickkopf-related protein 1 precursor [KO:K02165]
23002  DAAM1; disheveled-associated activator of morphogenesis 1 isoform 1 [KO:K04512]
23236  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a [KO:K05858] [EC:3.1.4.11]
23291  FBXW11; F-box/WD repeat-containing protein 11 isoform C [KO:K03362]
23401  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
23411  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform a [KO:K11411] [EC:2.3.1.286]
23500  DAAM2; disheveled-associated activator of morphogenesis 2 isoform 1 [KO:K04512]
2487  FRZB; secreted frizzled-related protein 3 precursor [KO:K25481]
2535  FZD2; frizzled-2 precursor [KO:K02235]
25776  CBY1; protein chibby homolog 1 [KO:K23402]
25805  BAMBI; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162]
27101  CACYBP; calcyclin-binding protein isoform 1 [KO:K04507]
27121  DKK4; dickkopf-related protein 4 precursor [KO:K02165]
27123  DKK2; dickkopf-related protein 2 precursor [KO:K02165]
27130  INVS; inversin isoform a [KO:K19626]
283106  CSNK2A3; casein kinase II subunit alpha 3 [KO:K03097] [EC:2.7.11.1]
284654  RSPO1; R-spondin-1 isoform 1 precursor [KO:K19471]
2932  GSK3B; glycogen synthase kinase-3 beta isoform 2 [KO:K03083] [EC:2.7.11.26]
29964  PRICKLE4; prickle-like protein 4 [KO:K04511]
324  APC; adenomatous polyposis coli protein isoform b [KO:K02085]
340419  RSPO2; R-spondin-2 isoform 1 precursor [KO:K23097]
343637  RSPO4; R-spondin-4 isoform 1 precursor [KO:K23099]
3725  JUN; transcription factor Jun [KO:K04448]
387  RHOA; transforming protein RhoA isoform 1 precursor [KO:K04513]
4007  PRICKLE3; prickle planar cell polarity protein 3 isoform 1 [KO:K04511]
4040  LRP6; low-density lipoprotein receptor-related protein 6 isoform b precursor [KO:K03068]
4041  LRP5; low-density lipoprotein receptor-related protein 5 isoform 1 precursor [KO:K03068]
4088  SMAD3; mothers against decapentaplegic homolog 3 isoform 1 [KO:K23605]
4089  SMAD4; mothers against decapentaplegic homolog 4 isoform a [KO:K04501]
4163  MCC; colorectal mutant cancer protein isoform 2 [KO:K26734]
4316  MMP7; matrilysin preproprotein [KO:K01397] [EC:3.4.24.23]
440193  CCDC88C; protein Daple [KO:K25811]
4609  MYC; myc proto-oncogene protein isoform 1 [KO:K04377]
4772  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform F [KO:K04446]
4773  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform C [KO:K17332]
4775  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform 1 [KO:K17333]
4776  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform 2 [KO:K17334]
4919  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor [KO:K05122] [EC:2.7.10.1]
4920  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 isoform 1 precursor [KO:K05123] [EC:2.7.10.1]
50964  SOST; sclerostin precursor [KO:K16834]
51176  LEF1; lymphoid enhancer-binding factor 1 isoform 1 [KO:K04492]
51384  WNT16; protein Wnt-16 isoform 1 precursor [KO:K01558]
51701  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
5176  SERPINF1; pigment epithelium-derived factor isoform 1 precursor [KO:K19614]
5330  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1 [KO:K05858] [EC:3.1.4.11]
5331  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1 [KO:K05858] [EC:3.1.4.11]
5332  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform b [KO:K05858] [EC:3.1.4.11]
54361  WNT4; protein Wnt-4 precursor [KO:K00408]
5467  PPARD; peroxisome proliferator-activated receptor delta isoform 1 [KO:K04504]
54894  RNF43; E3 ubiquitin-protein ligase RNF43 isoform 1 precursor [KO:K15694] [EC:2.3.2.27]
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348] [EC:3.1.3.16]
5532  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b [KO:K04348] [EC:3.1.3.16]
5533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348] [EC:3.1.3.16]
5534  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
5535  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
55366  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1 precursor [KO:K04309]
5566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
5578  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
5579  PRKCB; protein kinase C beta type isoform 1 [KO:K19662] [EC:2.7.11.13]
5582  PRKCG; protein kinase C gamma type isoform 2 [KO:K19663] [EC:2.7.11.13]
5599  MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
5663  PSEN1; presenilin-1 isoform I-467 [KO:K04505] [EC:3.4.23.-]
56998  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
57216  VANGL2; vang-like protein 2 [KO:K04510]
57680  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform 1 [KO:K04494] [EC:5.6.2.-]
57805  CCAR2; cell cycle and apoptosis regulator protein 2 isoform 1 [KO:K25816]
5879  RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392]
5880  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
5881  RAC3; ras-related C3 botulinum toxin substrate 3 isoform 1 [KO:K07861]
59343  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
59352  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor [KO:K08399]
595  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
6259  RYK; tyrosine-protein kinase RYK isoform 2 precursor [KO:K05128] [EC:2.7.10.1]
6422  SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166]
6423  SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176]
6424  SFRP4; secreted frizzled-related protein 4 precursor [KO:K02185]
6425  SFRP5; secreted frizzled-related protein 5 precursor [KO:K02222]
64321  SOX17; transcription factor SOX-17 [KO:K04495]
6477  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform a [KO:K04506] [EC:2.3.2.27]
64840  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform D [KO:K00181] [EC:2.3.1.250]
6500  SKP1; S-phase kinase-associated protein 1 isoform b [KO:K03094]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform B [KO:K04427] [EC:2.7.11.25]
6907  TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform a [KO:K04508]
6932  TCF7; transcription factor 7 isoform 1 [KO:K02620]
6934  TCF7L2; transcription factor 7-like 2 isoform 17 [KO:K04491]
7088  TLE1; transducin-like enhancer protein 1 isoform 2 [KO:K04497]
7089  TLE2; transducin-like enhancer protein 2 isoform 1 [KO:K04497]
7090  TLE3; transducin-like enhancer protein 3 isoform a [KO:K04497]
7091  TLE4; transducin-like enhancer protein 4 isoform 3 [KO:K04497]
7157  TP53; cellular tumor antigen p53 isoform a [KO:K04451]
7471  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
7472  WNT2; protein Wnt-2 precursor [KO:K00182]
7473  WNT3; proto-oncogene Wnt-3 precursor [KO:K00312]
7474  WNT5A; protein Wnt-5a isoform 1 precursor [KO:K00444]
7475  WNT6; protein Wnt-6 precursor [KO:K00445]
7476  WNT7A; protein Wnt-7a precursor [KO:K00572]
7477  WNT7B; protein Wnt-7b isoform 2 precursor [KO:K00572]
7478  WNT8A; protein Wnt-8a isoform 3 precursor [KO:K00714]
7479  WNT8B; protein Wnt-8b precursor [KO:K00714]
7480  WNT10B; protein Wnt-10b precursor [KO:K01357]
7481  WNT11; protein Wnt-11 precursor [KO:K01384]
7482  WNT2B; protein Wnt-2b isoform WNT-2B2 [KO:K00182]
7483  WNT9A; protein Wnt-9a precursor [KO:K01064]
7484  WNT9B; protein Wnt-9b isoform 1 precursor [KO:K01064]
7855  FZD5; frizzled-5 precursor [KO:K02375]
79718  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform 1 [KO:K04508]
7976  FZD3; frizzled-3 isoform 1 precursor [KO:K02329]
79816  TLE6; transducin-like enhancer protein 6 isoform 1 [KO:K04497]
80319  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
80326  WNT10A; protein Wnt-10a precursor [KO:K01357]
8061  FOSL1; fos-related antigen 1 isoform 1 [KO:K04502]
81029  WNT5B; protein Wnt-5b precursor [KO:K00444]
815  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 [KO:K04515] [EC:2.7.11.17]
816  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1 [KO:K04515] [EC:2.7.11.17]
817  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3 [KO:K04515] [EC:2.7.11.17]
818  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7 [KO:K04515] [EC:2.7.11.17]
81839  VANGL1; vang-like protein 1 isoform 1 [KO:K04510]
8312  AXIN1; axin-1 isoform a [KO:K02157]
8313  AXIN2; axin-2 isoform 1 [KO:K04385]
8321  FZD1; frizzled-1 [KO:K02432]
8322  FZD4; frizzled-4 precursor [KO:K02354]
8323  FZD6; frizzled-6 isoform a precursor [KO:K02376]
8324  FZD7; frizzled-7 precursor [KO:K02432]
8325  FZD8; frizzled-8 precursor [KO:K02375]
8326  FZD9; frizzled-9 precursor [KO:K02842]
83439  TCF7L1; transcription factor 7-like 1 [KO:K04490]
84133  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor [KO:K16273] [EC:2.3.2.27]
84445  LZTS2; leucine zipper putative tumor suppressor 2 isoform a [KO:K26471]
8454  CUL1; cullin-1 [KO:K03347]
84870  RSPO3; R-spondin-3 precursor [KO:K23098]
85407  NKD1; protein naked cuticle homolog 1 [KO:K03213]
85409  NKD2; protein naked cuticle homolog 2 isoform 1 [KO:K03213]
8549  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1 precursor [KO:K04308]
8607  RUVBL1; ruvB-like 1 isoform 1 [KO:K04499] [EC:5.6.2.4]
8840  CCN4; CCN family member 4 isoform 1 precursor [KO:K22471]
894  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
8945  BTRC; F-box/WD repeat-containing protein 1A isoform 1 [KO:K03362]
896  CCND3; G1/S-specific cyclin-D3 isoform 2 [KO:K10152]
89780  WNT3A; protein Wnt-3a precursor [KO:K00312]
90665  TBL1Y; F-box-like/WD repeat-containing protein TBL1Y [KO:K04508]
9350  CER1; cerberus precursor [KO:K01645]
9475  ROCK2; rho-associated protein kinase 2 isoform 1 [KO:K17388] [EC:2.7.11.39]
9620  CELSR1; cadherin EGF LAG seven-pass G-type receptor 1 isoform 2 precursor [KO:K04600]
9978  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
hsa04010  MAPK signaling pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04350  TGF-beta signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa05010  Alzheimer disease
KO pathway
ko04310   

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