KEGG   PATHWAY: hsa04810
Entry
hsa04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Homo sapiens (human)
Class
Cellular Processes; Cell motility
Pathway map
hsa04810  Regulation of actin cytoskeleton
hsa04810

Network
  Element
N00405  CXCR4-GNA12/13-Rho signaling pathway
N01068  ITGA/B-FAK-RAC signaling pathway
N01097  LPA-GNA12/13-RhoA signaling pathway
N01161  Actin polymerization
N01768  CXCR4-GNA12/13 signaling pathway
Drug
D01175  Carpronium chloride (JAN/INN)
D01840  Fasudil hydrochloride (JAN)
D03065  Becaplermin (USAN/INN)
D03115  Fasudil hydrochloride hydrate (JAN)
D03497  Cilengitide (USAN/INN)
D03722  Efegatran sulfate (USAN)
D03728  Napsagatran (USAN)
D04492  Icatibant acetate (JAN/USAN)
D05338  Palifermin (USAN/INN)
D05716  Repifermin (USAN/INN)
D06319  Volociximab (USAN)
D07941  Fasudil (INN)
D09342  Etaracizumab (USAN/INN)
D09752  Carpronium chloride hydrate (JAN)
D10028  Valategrast hydrochloride (USAN)
D10374  Lifitegrast (USAN/INN)
D10392  Lifitegrast sodium (USAN)
D10463  Ripasudil hydrochloride hydrate (JAN)
D12722  Bexotegrast (USAN/INN)
Other DBs
GO: 0030036
Organism
Homo sapiens (human) [GN:hsa]
Gene
1902  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
9170  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
2846  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
57121  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
6387  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
7852  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
2147  F2; coagulation factor II, thrombin [KO:K01313] [EC:3.4.21.5]
2149  F2R; coagulation factor II thrombin receptor [KO:K03914]
3630  INS; insulin [KO:K04526]
1950  EGF; epidermal growth factor [KO:K04357]
2246  FGF1; fibroblast growth factor 1 [KO:K18496]
2247  FGF2; fibroblast growth factor 2 [KO:K18497]
2248  FGF3; fibroblast growth factor 3 [KO:K04358]
2249  FGF4; fibroblast growth factor 4 [KO:K04358]
8822  FGF17; fibroblast growth factor 17 [KO:K04358]
2251  FGF6; fibroblast growth factor 6 [KO:K04358]
2252  FGF7; fibroblast growth factor 7 [KO:K04358]
2253  FGF8; fibroblast growth factor 8 [KO:K04358]
2254  FGF9; fibroblast growth factor 9 [KO:K04358]
2255  FGF10; fibroblast growth factor 10 [KO:K04358]
8823  FGF16; fibroblast growth factor 16 [KO:K04358]
2250  FGF5; fibroblast growth factor 5 [KO:K04358]
8817  FGF18; fibroblast growth factor 18 [KO:K04358]
26281  FGF20; fibroblast growth factor 20 [KO:K04358]
27006  FGF22; fibroblast growth factor 22 [KO:K04358]
9965  FGF19; fibroblast growth factor 19 [KO:K22603]
26291  FGF21; fibroblast growth factor 21 [KO:K22429]
8074  FGF23; fibroblast growth factor 23 [KO:K22428]
5154  PDGFA; platelet derived growth factor subunit A [KO:K04359]
5155  PDGFB; platelet derived growth factor subunit B [KO:K17386]
56034  PDGFC; platelet derived growth factor C [KO:K05450]
80310  PDGFD; platelet derived growth factor D [KO:K05450]
3645  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2260  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
2263  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
5156  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
5159  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
2335  FN1; fibronectin 1 [KO:K05717]
3672  ITGA1; integrin subunit alpha 1 [KO:K06480]
3673  ITGA2; integrin subunit alpha 2 [KO:K06481]
3674  ITGA2B; integrin subunit alpha 2b [KO:K06476]
3675  ITGA3; integrin subunit alpha 3 [KO:K06482]
3676  ITGA4; integrin subunit alpha 4 [KO:K06483]
3678  ITGA5; integrin subunit alpha 5 [KO:K06484]
3655  ITGA6; integrin subunit alpha 6 [KO:K06485]
3679  ITGA7; integrin subunit alpha 7 [KO:K06583]
8516  ITGA8; integrin subunit alpha 8 [KO:K06584]
3680  ITGA9; integrin subunit alpha 9 [KO:K06585]
8515  ITGA10; integrin subunit alpha 10 [KO:K06586]
22801  ITGA11; integrin subunit alpha 11 [KO:K06587]
3685  ITGAV; integrin subunit alpha V [KO:K06487]
3683  ITGAL; integrin subunit alpha L [KO:K05718]
3684  ITGAM; integrin subunit alpha M [KO:K06461]
3687  ITGAX; integrin subunit alpha X [KO:K06462]
3681  ITGAD; integrin subunit alpha D [KO:K06594]
3682  ITGAE; integrin subunit alpha E [KO:K06524]
3688  ITGB1; integrin subunit beta 1 [KO:K05719]
3689  ITGB2; integrin subunit beta 2 [KO:K06464]
3690  ITGB3; integrin subunit beta 3 [KO:K06493]
3691  ITGB4; integrin subunit beta 4 [KO:K06525]
3693  ITGB5; integrin subunit beta 5 [KO:K06588]
3694  ITGB6; integrin subunit beta 6 [KO:K06589]
3695  ITGB7; integrin subunit beta 7 [KO:K06590]
3696  ITGB8; integrin subunit beta 8 [KO:K06591]
3827  KNG1; kininogen 1 [KO:K03898]
623  BDKRB1; bradykinin receptor B1 [KO:K03915]
624  BDKRB2; bradykinin receptor B2 [KO:K03916]
1128  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
1129  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
1131  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
1132  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
1133  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
727  C5; complement C5 [KO:K03994]
729  C6; complement C6 [KO:K03995]
730  C7; complement C7 [KO:K03996]
731  C8A; complement C8 alpha chain [KO:K03997]
732  C8B; complement C8 beta chain [KO:K03998]
733  C8G; complement C8 gamma chain [KO:K03999]
735  C9; complement C9 [KO:K04000]
2768  GNA12; G protein subunit alpha 12 [KO:K04346]
10672  GNA13; G protein subunit alpha 13 [KO:K04639]
55970  GNG12; G protein subunit gamma 12 [KO:K04347]
2245  FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
89846  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
9564  BCAR1; BCAR1 scaffold protein, Cas family member [KO:K05726]
1398  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
1399  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
1793  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
6237  RRAS; RAS related [KO:K07829]
22800  RRAS2; RAS related 2 [KO:K07830]
22808  MRAS; muscle RAS oncogene homolog [KO:K07831]
9459  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
110117499  P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough [KO:K02649]
10451  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
7409  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
7410  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
7074  TIAM1; TIAM Rac1 associated GEF 1 [KO:K05731]
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
4342  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
28984  RGCC; regulator of cell cycle [KO:K26108]
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
2909  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
387  RHOA; ras homolog family member A [KO:K04513]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
5880  RAC2; Rac family small GTPase 2 [KO:K07860]
5881  RAC3; Rac family small GTPase 3 [KO:K07861]
998  CDC42; cell division cycle 42 [KO:K04393]
5058  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
5062  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
5063  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
10298  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
57144  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
56924  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
106821730  BUB1B-PAK6; BUB1B-PAK6 readthrough [KO:K05735] [EC:2.7.11.1]
8874  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
28964  GIT1; GIT ArfGAP 1 [KO:K05737]
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
4638  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
85366  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
91807  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
340156  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
4659  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
4660  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
54776  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
4633  MYL2; myosin light chain 2 [KO:K10351]
4636  MYL5; myosin light chain 5 [KO:K12753]
58498  MYL7; myosin light chain 7 [KO:K12754]
10398  MYL9; myosin light chain 9 [KO:K12755]
93408  MYL10; myosin light chain 10 [KO:K12756]
103910  MYL12B; myosin light chain 12B [KO:K12757]
10627  MYL12A; myosin light chain 12A [KO:K12757]
29895  MYL11; myosin light chain 11 [KO:K12758]
4627  MYH9; myosin heavy chain 9 [KO:K10352]
4628  MYH10; myosin heavy chain 10 [KO:K10352]
4629  MYH11; myosin heavy chain 11 [KO:K10352]
79784  MYH14; myosin heavy chain 14 [KO:K10352]
1729  DIAPH1; diaphanous related formin 1 [KO:K05740]
1730  DIAPH2; diaphanous related formin 2 [KO:K05741]
6548  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
23396  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
8394  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
8395  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
79837  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
5305  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
8396  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
200576  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
3984  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
3985  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
81624  DIAPH3; diaphanous related formin 3 [KO:K05745]
10458  BAIAP2; BAR/IMD domain containing adaptor protein 2 [KO:K05627]
55740  ENAH; ENAH actin regulator [KO:K05746]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
10163  WASF2; WASP family member 2 [KO:K05748]
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
10787  NCKAP1; NCK associated protein 1 [KO:K05750]
3071  NCKAP1L; NCK associated protein 1 like [KO:K05750]
10152  ABI2; abl interactor 2 [KO:K05751]
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex [KO:K05752]
8936  WASF1; WASP family member 1 [KO:K05753]
10097  ACTR2; actin related protein 2 [KO:K17260]
57180  ACTR3B; actin related protein 3B [KO:K18584]
653857  ACTR3C; actin related protein 3C [KO:K18584]
10096  ACTR3; actin related protein 3 [KO:K18584]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
71  ACTG1; actin gamma 1 [KO:K05692]
60  ACTB; actin beta [KO:K05692]
345456  PFN3; profilin 3 [KO:K05759]
5216  PFN1; profilin 1 [KO:K05759]
5217  PFN2; profilin 2 [KO:K05759]
375189  PFN4; profilin family member 4 [KO:K05759]
5829  PXN; paxillin [KO:K05760]
7430  EZR; ezrin [KO:K08007]
5962  RDX; radixin [KO:K05762]
4478  MSN; moesin [KO:K05763]
7114  TMSB4X; thymosin beta 4 X-linked [KO:K05764]
9087  TMSB4Y; thymosin beta 4 Y-linked [KO:K05764]
1072  CFL1; cofilin 1 [KO:K05765]
1073  CFL2; cofilin 2 [KO:K05765]
54434  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
54961  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
85464  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
7414  VCL; vinculin [KO:K05700]
8826  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
10788  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
128239  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
2934  GSN; gelsolin [KO:K05768]
85477  SCIN; scinderin [KO:K05768]
87  ACTN1; actinin alpha 1 [KO:K05699]
81  ACTN4; actinin alpha 4 [KO:K05699]
324  APC; APC regulator of WNT signaling pathway [KO:K02085]
10297  APC2; APC regulator of WNT signaling pathway 2 [KO:K02085]
50649  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
221178  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hsa04010  MAPK signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
KO pathway
ko04810   

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Network (5)   
   KEGG NETWORK (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (230)   
   KEGG GENES (230)   
All databases (236)   

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