KEGG   PATHWAY: ko00460
Entry
ko00460                     Pathway                                

Name
Cyanoamino acid metabolism
Class
Metabolism; Metabolism of other amino acids
Pathway map
ko00460  Cyanoamino acid metabolism
ko00460

Module
M00369  Cyanogenic glycoside biosynthesis, tyrosine => dhurrin [PATH:ko00460]
Other DBs
GO: 0033052 0019756
Orthology
K13027  tyrosine N-monooxygenase [EC:1.14.14.36]
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
K13030  cyanohydrin beta-glucosyltransferase [EC:2.4.1.85]
K01188  beta-glucosidase [EC:3.2.1.21]
K05349  beta-glucosidase [EC:3.2.1.21]
K05350  beta-glucosidase [EC:3.2.1.21]
K08249  hydroxymandelonitrile lyase [EC:4.1.2.11]
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
K13401  valine N-monooxygenase [EC:1.14.14.38]
K16265  (E)-2-methylbutanal oxime monooxygenase [EC:1.14.14.41]
K16266  cyanohydrin UDP-glucosyltransferase [EC:2.4.1.-]
K14577  aliphatic (R)-hydroxynitrile lyase [EC:4.1.2.46]
K13033  (S)-hydroxynitrile lyase [EC:4.1.2.47]
K12153  phenylalanine N-monooxygenase [EC:1.14.14.40]
K00495  phenylacetaldehyde oxime monooxygenase [EC:1.14.14.44]
K10566  phenylacetaldoxime dehydratase [EC:4.99.1.7]
K22706  (R)-mandelonitrile beta-glucosyltransferase [EC:2.4.1.354]
K13031  amygdalin beta-glucosidase [EC:3.2.1.117]
K13032  prunasin beta-glucosidase [EC:3.2.1.118]
K08248  (R)-mandelonitrile lyase [EC:4.1.2.10]
K20802  (R)-mandelonitrile lyase [EC:4.1.2.10]
K01501  nitrilase [EC:3.5.5.1]
K13034  L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
K00681  gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
K18592  gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
K13035  beta-cyano-L-alanine hydratase/nitrilase [EC:3.5.5.4 4.2.1.65]
K01424  L-asparaginase [EC:3.5.1.1]
K13051  L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]
K01914  aspartate--ammonia ligase [EC:6.3.1.1]
K00600  glycine hydroxymethyltransferase [EC:2.1.2.1]
K10814  hydrogen cyanide synthase HcnA [EC:1.4.99.5]
K10815  hydrogen cyanide synthase HcnB [EC:1.4.99.5]
K10816  hydrogen cyanide synthase HcnC [EC:1.4.99.5]
K18282  cyanide dihydratase [EC:3.5.5.-]
K10675  cyanide hydratase [EC:4.2.1.66]
K01455  formamidase [EC:3.5.1.49]
Compound
C00014  Ammonia
C00037  Glycine
C00049  L-Aspartate
C00065  L-Serine
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00097  L-Cysteine
C00152  L-Asparagine
C00183  L-Valine
C00302  Glutamate
C00407  L-Isoleucine
C00488  Formamide
C00561  Mandelonitrile
C00844  Prunasin
C01326  Hydrogen cyanide
C01401  Alanine
C01594  Linamarin
C02512  3-Cyano-L-alanine
C02659  Acetone cyanohydrin
C03004  N-Hydroxy-L-tyrosine
C03219  (E)-2-Methylpropanal oxime
C03742  (S)-4-Hydroxymandelonitrile
C04350  (E)-4-Hydroxyphenylacetaldehyde oxime
C05143  Dhurrin
C05670  3-Aminopropiononitrile
C05711  gamma-Glutamyl-beta-cyanoalanine
C05714  alpha-Aminopropiononitrile
C05715  gamma-Amino-gamma-cyanobutanoate
C06114  gamma-Glutamyl-beta-aminopropiononitrile
C08325  Amygdalin
C08334  Lotaustralin
C15503  N,N-Dihydroxy-L-tyrosine
C16074  Phenylacetonitrile
C16075  (Z)-Phenylacetaldehyde oxime
C18796  (2R)-2-Hydroxy-2-methylbutanenitrile
C19491  (E)-2-Methylbutanal oxime
C19712  N-Hydroxy-L-phenylalanine
C19714  (E)-Phenylacetaldoxime
C19715  N,N-Dihydroxy-L-phenylalanine
C20310  N-Hydroxy-L-isoleucine
C20311  N,N-Dihydroxy-L-isoleucine
C20312  (Z)-2-Methylbutanal oxime
C20313  N-Hydroxy-L-valine
C20314  N,N-Dihydroxy-L-valine
C20315  (Z)-2-Methylpropanal oxime
Reference
  Authors
Maruyama A, Saito K, Ishizawa K
  Title
Beta-cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation.
  Journal
Plant Mol Biol 46:749-60 (2001)
DOI:10.1023/A:1011629703784
Reference
  Authors
Andersen MD, Busk PK, Svendsen I, Moller BL
  Title
Cytochromes P-450 from cassava (Manihot esculenta Crantz) catalyzing the first steps in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin. Cloning, functional expression in Pichia pastoris, and substrate specificity of the isolated recombinant enzymes.
  Journal
J Biol Chem 275:1966-75 (2000)
DOI:10.1074/jbc.275.3.1966
Reference
  Authors
Hickel A, Hasslacher M, Griengl H.
  Title
Hydroxynitrile lyases: Functions and properties
  Journal
Physiologia Plantarum 98(4):891-898 (2006)
DOI:10.1111/j.1399-3054.1996.tb06700.x
Related
pathway
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00290  Valine, leucine and isoleucine biosynthesis
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00410  beta-Alanine metabolism
ko00450  Selenocompound metabolism
ko00471  D-Glutamine and D-glutamate metabolism
ko00472  D-Arginine and D-ornithine metabolism
ko00473  D-Alanine metabolism
ko00480  Glutathione metabolism
ko00910  Nitrogen metabolism

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