KEGG   PATHWAY: ko00730
Entry
ko00730                     Pathway                                
Name
Thiamine metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00730  Thiamine metabolism
ko00730

Module
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:ko00730]
M00895  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/glycine) => TMP/TPP [PATH:ko00730]
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:ko00730]
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP [PATH:ko00730]
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP [PATH:ko00730]
M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:ko00730]
Other DBs
GO: 0006772
Orthology
K03147  phosphomethylpyrimidine synthase [EC:4.1.99.17]
K00877  hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 3.5.99.2]
K00941  hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]
K14153  hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3]
K21219  hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase [EC:2.7.1.49 2.7.4.7 2.5.1.3]
K18278  pyrimidine precursor biosynthesis enzyme
K03148  sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73]
K04487  cysteine desulfurase [EC:2.8.1.7]
K03151  tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
K03150  2-iminoacetate synthase [EC:4.1.99.19]
K03153  glycine oxidase [EC:1.4.3.19]
K01662  1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]
K03149  thiazole synthase [EC:2.8.1.10]
K10810  thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10]
K03146  cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
K00878  hydroxyethylthiazole kinase [EC:2.7.1.50]
K00788  thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]
K21220  thiamine-phosphate diphosphorylase [EC:2.5.1.3]
K14154  thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase [EC:2.5.1.3 2.7.1.50]
K00946  thiamine-monophosphate kinase [EC:2.7.4.16]
K06928  nucleoside-triphosphatase [EC:3.6.1.15]
K06949  ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
K22911  thiamine phosphate phosphatase / amino-HMP aminohydrolase [EC:3.1.3.100 3.5.99.-]
K01077  alkaline phosphatase [EC:3.1.3.1]
K01078  acid phosphatase [EC:3.1.3.2]
K23458  repressible acid phosphatase [EC:3.1.3.2]
K14394  low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48]
K07251  thiamine kinase [EC:2.7.1.89]
K00949  thiamine pyrophosphokinase [EC:2.7.6.2]
K00939  adenylate kinase [EC:2.7.4.3]
K05307  thiamine-triphosphatase [EC:3.6.1.28]
K10811  thiamine pyridinylase [EC:2.5.1.2]
K03707  thiaminase (transcriptional activator TenA) [EC:3.5.99.2]
K20895  formylaminopyrimidine deformylase [EC:3.5.1.-]
K20896  formylaminopyrimidine deformylase / aminopyrimidine aminohydrolase [EC:3.5.1.- 3.5.99.-]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00230  Purine metabolism
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00750  Vitamin B6 metabolism

  All links  
Gene (36)   
   KEGG ORTHOLOGY (36)   
All databases (36)   

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