KEGG   PATHWAY: ko00830
Entry
ko00830                     Pathway                                
Name
Retinol metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
ko00830  Retinol metabolism
ko00830

Other DBs
GO: 0006776
Orthology
K00515  beta-carotene 15,15'-dioxygenase [EC:1.13.11.63]
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K11146  short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]
K11147  dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]
K11148  dehydrogenase/reductase SDR family member 4-like protein 2 [EC:1.1.-.-]
K11149  dehydrogenase/reductase SDR family member 9 [EC:1.1.-.-]
K11150  retinol dehydrogenase 8 [EC:1.1.1.-]
K11151  retinol dehydrogenase 10 [EC:1.1.1.-]
K11152  retinol dehydrogenase 11 [EC:1.1.1.300]
K11153  retinol dehydrogenase 12 [EC:1.1.1.300]
K11161  retinol dehydrogenase 13 [EC:1.1.1.300]
K11154  retinol dehydrogenase 16 [EC:1.1.1.-]
K15734  all-trans-retinol dehydrogenase (NAD+) [EC:1.1.1.105]
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
K00678  phosphatidylcholine-retinol O-acyltransferase [EC:2.3.1.135]
K11155  diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]
K11156  diacylglycerol O-acyltransferase 2-like protein 4 [EC:2.3.1.75 2.3.1.76]
K11157  patatin-like phospholipase domain-containing protein 4 [EC:3.1.1.-]
K11158  retinoid isomerohydrolase / lutein isomerase [EC:3.1.1.64 5.3.3.22]
K00061  11-cis-retinol dehydrogenase [EC:1.1.1.315]
K00157  aldehyde oxidase [EC:1.2.3.1]
K07249  retinal dehydrogenase [EC:1.2.1.36]
K07437  cytochrome P450 family 26 subfamily A [EC:1.14.14.-]
K12664  cytochrome P450 family 26 subfamily B [EC:1.14.14.-]
K12665  cytochrome P450 family 26 subfamily C [EC:1.14.14.-]
K07408  cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S1 [EC:1.14.14.1]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
K17691  cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07423  cytochrome P450 family 2 subfamily W1 [EC:1.14.14.-]
K07425  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K00699  glucuronosyltransferase [EC:2.4.1.17]
K09516  all-trans-retinol 13,14-reductase [EC:1.3.99.23]
K17951  all-trans-retinol 3,4-desaturase [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
Related
pathway
ko00906  Carotenoid biosynthesis

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Gene (50)   
   KEGG ORTHOLOGY (50)   
All databases (50)   

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