KEGG   PATHWAY: ko04011
Entry
ko04011                     Pathway                                
Name
MAPK signaling pathway - yeast
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
ko04011  MAPK signaling pathway - yeast
ko04011

Other DBs
GO: 0000165
Orthology
K11234  mating pheromone alpha-factor
K11235  mating pheromone A-factor
K01383  barrierpepsin [EC:3.4.23.35]
K11213  pheromone alpha factor receptor
K04627  pheromone a factor receptor
K02218  casein kinase 1 [EC:2.7.11.1]
K10591  E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
K19860  guanine nucleotide-binding protein alpha-1 subunit
K04536  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K07973  guanine nucleotide-binding protein subunit gamma, fungi
K19838  GTPase-activating protein SST2
K11236  cell division control protein 24
K04393  cell division control protein 42
K19839  Rho-type GTPase-activating protein 1/2
K19840  Rho-type GTPase-activating protein
K11237  bud emergence protein 1
K04409  p21-activated kinase 1 [EC:2.7.11.1]
K19833  serine/threonine-protein kinase CLA4 [EC:2.7.11.1]
K11238  cytokinesis protein
K11228  mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K19841  protein STE50
K11239  pheromone-response scaffold protein
K11226  mitogen-activated protein kinase kinase [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K19806  tyrosine-protein phosphatase 2/3 [EC:3.1.3.48]
K11240  tyrosine-protein phosphatase MSG5 [EC:3.1.3.48]
K19812  dual-specificity protein phosphatase SDP1 [EC:3.1.3.48]
K11215  transcription factor STE12
K11241  down-regulator of invasive growth 1
K11242  down-regulator of invasive growth 2
K12412  pheromone receptor transcription factor
K11243  nuclear fusion protein
K06652  cyclin-dependent kinase inhibitor FAR1
K12760  G1/S-specific cyclin CLN1
K06650  G1/S-specific cyclin CLN2
K04563  cyclin-dependent kinase [EC:2.7.11.22]
K11244  cell wall integrity and stress response component
K11245  mating pheromone-induced death protein 2
K19842  RHO1 GDP-GTP exchange protein 1/2
K19843  Rho1 guanine nucleotide exchange factor TUS1
K00888  phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K04513  Ras homolog gene family, member A
K19844  GTPase-activating protein BEM2
K19845  GTPase-activating protein SAC7
K17971  BNI1-related protein 1
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K11229  mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K08294  mitogen-activated protein kinase kinase [EC:2.7.12.2]
K19846  protein SPA2
K04464  mitogen-activated protein kinase 7 [EC:2.7.11.24]
K19847  MPK-like protein 1
K09265  transcription factor RLM1
K00706  1,3-beta-glucan synthase [EC:2.4.1.34]
K15174  RNA polymerase II-associated factor 1
K06649  regulatory protein SWI4
K06648  regulatory protein SWI6
K02555  M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
K02220  G2/mitotic-specific cyclin 1
K23469  G2/mitotic-specific cyclin 2
K19848  signaling mucin HKR1
K19849  signaling mucin MSB2
K11246  SHO1 osmosensor
K19850  protein OPY2
K11231  osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3]
K11232  osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233  osomolarity two-component system, response regulator SSK1
K11230  mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
K11227  mitogen-activated protein kinase kinase [EC:2.7.12.2]
K04441  p38 MAP kinase [EC:2.7.11.24]
K19704  protein phosphatase PTC1 [EC:3.1.3.16]
K19815  high-osmolarity-induced transcription protein 1
K19807  transcription factor SMP1
K00006  glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
K09468  zinc finger protein MSN2/4
K03781  catalase [EC:1.11.1.6]
K09051  ATF/CREB family transcription factor
K06665  general transcriptional corepressor CYC8
K06666  general transcriptional corepressor TUP1
K17741  NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
K03085  substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K06651  S-phase entry cyclin 5/6
K02515  serine/threonine-protein kinase HSL1, negative regulator of Swe1 kinase [EC:2.7.11.-]
K02516  type II protein arginine methyltransferase [EC:2.1.1.320]
K03114  mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
K06009  yapsin 1/2 [EC:3.4.23.41]
K06630  14-3-3 protein epsilon
K19816  transcription activator MSS11
K09448  transcriptional enhancer factor
K19851  flocculation protein FLO11
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003

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Gene (91)   
   KEGG ORTHOLOGY (91)   
All databases (91)   

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