KEGG   PATHWAY: ko04612
Entry
ko04612                     Pathway                                

Name
Antigen processing and presentation
Class
Organismal Systems; Immune system
Pathway map
ko04612  Antigen processing and presentation
ko04612

Other DBs
GO: 0019885 0019886 0042591
Orthology
K04687  interferon gamma
K03156  tumor necrosis factor superfamily, member 2
K06696  proteasome activator subunit 1 (PA28 alpha)
K06697  proteasome activator subunit 2 (PA28 beta)
K06698  proteasome activator subunit 3 (PA28 gamma)
K03283  heat shock 70kDa protein 1/2/6/8
K09489  heat shock 70kDa protein 4
K04079  molecular chaperone HtpG
K06751  MHC class I antigen
K09490  endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
K08054  calnexin
K08055  beta-2-microglobulin
K08056  protein disulfide-isomerase A3 [EC:5.3.4.1]
K08057  calreticulin
K08058  TAP binding protein (tapasin)
K05653  ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654  ATP-binding cassette, subfamily B (MDR/TAP), member 3
K06458  T-cell surface glycoprotein CD8 alpha chain
K06459  T-cell surface glycoprotein CD8 beta chain
K10784  T cell receptor alpha chain V region
K10785  T-cell receptor beta chain V region
K07980  killer cell immunoglobulin-like receptor 3DL
K07981  killer cell immunoglobulin-like receptor 2DL1/2/3
K24231  killer cell immunoglobulin-like receptor 2DL4
K24232  killer cell immunoglobulin-like receptor 2DL5
K06541  killer cell lectin-like receptor subfamily C1
K24233  killer cell lectin-like receptor subfamily C2/3
K24234  killer cell lectin-like receptor subfamily C4
K06516  killer cell lectin-like receptor subfamily D member 1
K07982  killer cell immunoglobulin-like receptor 2DS
K08059  interferon, gamma-inducible protein 30
K01369  legumain [EC:3.4.22.34]
K01363  cathepsin B [EC:3.4.22.1]
K06752  MHC class II antigen
K06505  CD74 antigen
K01365  cathepsin L [EC:3.4.22.15]
K01368  cathepsin S [EC:3.4.22.27]
K06454  T-cell surface glycoprotein CD4
K08060  MHC class II transactivator [EC:2.7.11.1]
K08061  regulatory factor X 5
K08062  regulatory factor X-associated ankyrin-containing protein
K08063  regulatory factor X-associated protein
K05870  cyclic AMP-responsive element-binding protein 1
K08064  nuclear transcription factor Y, alpha
K08065  nuclear transcription Y subunit beta
K08066  nuclear transcription factor Y, gamma
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ko03050  Proteasome
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway

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