KEGG   PATHWAY: lml00020Help
Entry
lml00020                    Pathway                                

Name
Citrate cycle (TCA cycle) - Listeria monocytogenes L99
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
lml00020  Citrate cycle (TCA cycle)
lml00020

Ortholog table
Module
lml_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:lml00020]
lml_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:lml00020]
Other DBs
BSID: 612260
GO: 0006099
Organism
Listeria monocytogenes L99 [GN:lml]
Gene
lmo4a_1623  citZ; Citrate synthase [KO:K01647] [EC:2.3.3.1]
lmo4a_1701  acnA; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
lmo4a_1622  citC; isocitrate dehydrogenase, NADP-dependent [KO:K00031] [EC:1.1.1.42]
lmo4a_1064  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
lmo4a_1428  bfmBC; branched-chain alpha-keto acid dehydrogenase E3 subunit [KO:K00382] [EC:1.8.1.4]
lmo4a_0373  frdC; fumarate reductase, flavoprotein subunit [KO:K00244] [EC:1.3.5.4]
lmo4a_2286  fumC; fumarate hydratase, class II [KO:K01679] [EC:4.2.1.2]
lmo4a_1077  pycA; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
lmo4a_1061  pdhA; pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit [KO:K00161] [EC:1.2.4.1]
lmo4a_1062  pdhB; pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit [KO:K00162] [EC:1.2.4.1]
lmo4a_1063  pdhC; pyruvate dehydrogenase complex E2 component, dihydrolipoamide acetyltransferase [KO:K00627] [EC:2.3.1.12]
lmo4a_0839  pyruvate flavodoxin/ferredoxin oxidoreductase [KO:K03737] [EC:1.2.7.- 1.2.7.1]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
ko00020   

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